Iron Status and Restless Legs Syndrome in the Elderly

1994 ◽  
Vol 23 (3) ◽  
pp. 200-203 ◽  
Author(s):  
S. T. O'KEEFFE ◽  
K. GAVIN ◽  
J. N. LAVAN
Keyword(s):  
Restless Legs Syndrome ◽  
Iron Status ◽  
The Elderly ◽  
Restless Legs

scholarly journals Restless legs syndrome in the elderly.

1993 ◽  
Vol 69 (815) ◽  
pp. 701-703 ◽  
Author(s):  
S. T. O'Keeffe ◽  
J. Noel ◽  
J. N. Lavan
Keyword(s):  
Restless Legs Syndrome ◽  
The Elderly ◽  
Restless Legs

scholarly journals Mild Impairments in Cognitive Function in the Elderly with Restless Legs Syndrome

2013 ◽  
Vol 20 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Eun Soo Kim ◽  
In-Young Yoon ◽  
Kukju Kweon ◽  
Hye Youn Park ◽  
Chung Suk Lee ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Restless Legs Syndrome ◽  
The Elderly ◽  
Restless Legs

scholarly journals Restless Legs Syndrome Among the Elderly

2009 ◽  
Vol 3 (4) ◽  
pp. 197-203 ◽  
Author(s):  
Pei-Hao Chen ◽  
Shih-Jung Cheng
Keyword(s):  
Restless Legs Syndrome ◽  
The Elderly ◽  
Restless Legs

Iron status and chronic kidney disease predict restless legs syndrome in an older hospital population

2011 ◽  
Vol 12 (3) ◽  
pp. 295-301 ◽  
Author(s):  
Colin Quinn ◽  
Mateen Uzbeck ◽  
Imran Saleem ◽  
Paul Cotter ◽  
Javed Ali ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Restless Legs Syndrome ◽  
Iron Status ◽  
Restless Legs ◽  
Hospital Population

The Role of Iron in Pediatric Restless Legs Syndrome and Periodic Limb Movements in Sleep

2017 ◽  
Vol 37 (04) ◽  
pp. 439-445 ◽  
Author(s):  
Barbara Felt ◽  
Tiffany Munzer
Keyword(s):  
Restless Legs Syndrome ◽  
Pediatric Patients ◽  
Randomized Clinical Trials ◽  
Iron Status ◽  
Current Evidence ◽  
Future Research ◽  
Symptom Improvement ◽  
Periodic Limb Movements ◽  
Limb Movements ◽  
Restless Legs

AbstractRestless legs syndrome (RLS) is a common and treatable neurologic condition in pediatric patients, with a prevalence as high as 2 to 3%. The diagnosis of RLS is made clinically based on an urge to move the legs accompanied by lower extremity discomfort that occurs during rest usually later in the day and is relieved by movement. Periodic limb movements in sleep (PLMS) can overlap with RLS, although PLMS also exists as a separate entity characterized by stereotyped movements of lower extremities in sleep. Both conditions may be highly debilitating and interfere with daily function notably in the areas of educational attainment and behavioral regulation. Iron deficiency has been implicated in the pathophysiology of both RLS and PLMS. Current evidence suggests that treatment of ferritin levels < 50 µg/L may be beneficial in improving pediatric RLS symptoms and comorbid conditions or daytime dysfunction associated with RLS. Areas for future research include (1) clarifying the ferritin or other iron status measure level which predicts iron treatment will provide symptom improvement in pediatric patients, and (2) randomized clinical trials using iron therapy to determine the degree and duration of treatment.

scholarly journals Association of Proton Pump Inhibitor and Histamine H2-Receptor Antagonists with Restless Legs Syndrome

SLEEP ◽  
2020 ◽  
Author(s):  
Eric J Earley ◽  
Maria Didriksen ◽  
Bryan R Spencer ◽  
Joseph E Kiss ◽  
Christian Erikstrup ◽  
...  
Keyword(s):  
Proton Pump ◽  
Restless Legs Syndrome ◽  
Iron Status ◽  
Receptor Antagonists ◽  
H2 Receptor Antagonists ◽  
Histamine H2 Receptor ◽  
H2 Receptor ◽  
Iron Stores ◽  
Restless Legs ◽  
Supplement Use

Abstract Restless Legs Syndrome (RLS) is a common sensorimotor disorder, which can disrupt sleep and is thought to be caused in part by low cellular iron stores. Proton pump inhibitors (PPI) and histamine H2-receptor antagonists (H2A) are among the most commonly used drugs worldwide and show evidence of causing iron deficiency. We conducted a case/non-case observational study of blood donors in the U.S. (N=13,403; REDS-III) and Denmark (N=50,323; Danish Blood Donor Study, DBDS), both of which had complete blood count measures and a completed RLS assessment via the Cambridge Hopkins RLS questionnaire (CH-RLSq). After adjusting for age, sex, race, BMI, blood donation frequency, smoking, hormone use, and iron supplement use, PPI/H2A use was associated with RLS (Odds Ratio [OR] = 1.41; 95% confidence interval [CI], 1.13-1.76; P=0.002) in REDS-III for both PPI (OR = 1.43; CI, 1.03 – 1.95; P = 0.03) and H2A (OR = 1.56; CI, 1.10 – 2.16; P = 0.01). DBDS exhibited a similar association with PPIs/H2As (OR = 1.29; CI, 1.20 - 1.40; P &lt; 0.001), and for PPIs alone (OR = 1.27; CI, 1.17-1.38; P &lt; 0.001), but not H2As alone (OR = 1.18; CI, 0.92-1.53; P = 0.2). We found no evidence of blood iron stores mediating this association. The association of PPI, and possibly H2A, consumption with RLS independent of blood iron status and other factors which contribute to RLS risk suggest the need to re-evaluate use of PPI/H2A in populations at particular risk for RLS.

scholarly journals The Effect of Selected Core Stability Exercises on Restless Legs Syndrome and Quality of Life in the Elderly Undergoing Hemodialysis

2018 ◽  
Vol 12 (8) ◽  
pp. 48-58
Author(s):  
Mehrdad Bastani ◽  
Gholamali Ghasemi ◽  
Morteza sadeghi ◽  
◽  
◽  
...  
Keyword(s):  
Quality Of Life ◽  
Restless Legs Syndrome ◽  
The Elderly ◽  
Core Stability ◽  
Restless Legs
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