International survey of human herpes virus 8 screening and management in solid organ transplantation

2021 ◽  
Author(s):  
Mularoni Alessandra ◽  
Malgorzata Mikulska ◽  
Maddalena Giannella ◽  
Lucia Adamoli ◽  
Monica Slavin ◽  
...  
Keyword(s):  
Organ Transplantation ◽  
Herpes Virus ◽  
Solid Organ Transplantation ◽  
Solid Organ ◽  
International Survey ◽  
Human Herpes ◽  
Human Herpes Virus 8 ◽  
Human Herpes Virus ◽  
Herpès Virus

scholarly journals Primary Effusion Lymphoma Occurring in the Setting of Transplanted Patients: A Systematic Review of a Rare, Life-Threatening Post-Transplantation Occurrence

2021 ◽  
Author(s):  
Magda Zanelli ◽  
Francesca Sanguedolce ◽  
Maurizio Zizzo ◽  
Andrea Palicelli ◽  
Maria Chiara Bassi ◽  
...  
Keyword(s):  
Herpes Virus ◽  
Primary Effusion Lymphoma ◽  
Kaposi Sarcoma ◽  
Body Cavity ◽  
Solid Organ ◽  
Human Herpes ◽  
Human Herpes Virus 8 ◽  
Post Transplant ◽  
Human Herpes Virus ◽  
Herpès Virus

Abstract Background: Primary effusion lymphoma is a rare, aggressive large B-cell lymphoma strictly linked to infection by Human Herpes virus 8/Kaposi sarcoma-associated herpes virus. In its classic form, it is characterized by body cavities neoplastic effusions without detectable tumor masses. It often occurs in immunocompromised patients, such as HIV-positive individuals. Primary effusion lymphoma may affect HIV-negative elderly patients from Human Herpes virus 8 endemic regions. So far, rare cases have been reported in transplanted patients. The purpose of our systematic review is to improve our understanding of this type of aggressive lymphoma in the setting of transplantation, focusing on epidemiology, clinical presentation, pathological features, differential diagnosis, treatment and outcome. The role of assessing the viral serological status in donors and recipients is also discussed.Methods: Based on the PRISMA guidelines, we carried out a systematic search on PubMed/MEDLINE, Web of Science, Scopus, EMBASE and Cochrane Library using the search terms “primary effusion lymphoma” and “post-transplant”. Results: Our search identified 13 cases of post-transplant primary effusion lymphoma, predominantly in solid organ transplant recipients (6 kidney, 3 heart, 2 liver and 1 intestine), with only one case after allogenic bone marrow transplantation. Long-term immunosuppression is important in post-transplant primary effusion lymphoma commonly developing several years after transplantation. Kaposi Sarcoma occurred in association with lymphoma in 4 cases of solid organ recipients. The lymphoma showed the classical presentation with body cavity effusions in absence of tumor masses in 10 cases; 2 cases presented as solid masses, lacking effusions and one case as effusions associated with multiple organ involvement. Primary effusion lymphoma occurring in the setting of transplantation was more often Epstein Barr-virus negative. The prognosis was poor. In addition to chemotherapy, reduction of immunosuppressive treatment, was generally attempted.Conclusions: Primary effusion lymphoma is a rare, but often fatal post-transplant complication. Its rarity and the difficulty in achieving the diagnosis may lead to miss this complication. Clinicians should suspect primary effusion lymphoma in transplanted patients, presenting generally with unexplained body cavity effusions, although rare cases with solid masses are described.

MOLECULAR DETECTION OF KAPOSI’S SARCOMA ASSOCIATED VIRUS (HUMAN HERPES VIRUS 8) IN SINO-NASAL CARCINOMA TISSUES

2020 ◽  
Vol 23 (04) ◽  
pp. 286-297
Author(s):  
Hind Hamed Shaker ◽  
Luma Amer Yasir ◽  
Ausama Abed-Alkadum Alajeely ◽  
Saad Hasan Mohammed Ali ◽  
Shakir H. Mohammed Al-Alwany
Keyword(s):  
Kaposi's Sarcoma ◽  
Herpes Virus ◽  
Molecular Detection ◽  
Kaposi’S Sarcoma ◽  
Human Herpes ◽  
Human Herpes Virus 8 ◽  
Human Herpes Virus ◽  
Herpès Virus ◽  
Nasal Carcinoma

scholarly journals Primary effusion lymphoma occurring in the setting of transplanted patients: a systematic review of a rare, life-threatening post-transplantation occurrence

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Magda Zanelli ◽  
Francesca Sanguedolce ◽  
Maurizio Zizzo ◽  
Andrea Palicelli ◽  
Maria Chiara Bassi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Herpes Virus ◽  
Primary Effusion Lymphoma ◽  
Kaposi Sarcoma ◽  
Body Cavity ◽  
Solid Organ ◽  
Human Herpes Virus 8 ◽  
Post Transplant ◽  
Human Herpes Virus ◽  
Herpès Virus

Abstract Background Primary effusion lymphoma is a rare, aggressive large B-cell lymphoma strictly linked to infection by Human Herpes virus 8/Kaposi sarcoma-associated herpes virus. In its classic form, it is characterized by body cavities neoplastic effusions without detectable tumor masses. It often occurs in immunocompromised patients, such as HIV-positive individuals. Primary effusion lymphoma may affect HIV-negative elderly patients from Human Herpes virus 8 endemic regions. So far, rare cases have been reported in transplanted patients. The purpose of our systematic review is to improve our understanding of this type of aggressive lymphoma in the setting of transplantation, focusing on epidemiology, clinical presentation, pathological features, differential diagnosis, treatment and outcome. The role of assessing the viral serological status in donors and recipients is also discussed. Methods We performed a systematic review adhering to the PRISMA guidelines. The literature search was conducted on PubMed/MEDLINE, Web of Science, Scopus, EMBASE and Cochrane Library, using the search terms “primary effusion lymphoma” and “post-transplant”. Results Our search identified 13 cases of post-transplant primary effusion lymphoma, predominantly in solid organ transplant recipients (6 kidney, 3 heart, 2 liver and 1 intestine), with only one case after allogenic bone marrow transplantation. Long-term immunosuppression is important in post-transplant primary effusion lymphoma commonly developing several years after transplantation. Kaposi Sarcoma occurred in association with lymphoma in 4 cases of solid organ recipients. The lymphoma showed the classical presentation with body cavity effusions in absence of tumor masses in 10 cases; 2 cases presented as solid masses, lacking effusions and one case as effusions associated with multiple organ involvement. Primary effusion lymphoma occurring in the setting of transplantation was more often Epstein Barr-virus negative. The prognosis was poor. In addition to chemotherapy, reduction of immunosuppressive treatment, was generally attempted. Conclusions Primary effusion lymphoma is a rare, but often fatal post-transplant complication. Its rarity and the difficulty in achieving the diagnosis may lead to miss this complication. Clinicians should suspect primary effusion lymphoma in transplanted patients, presenting generally with unexplained body cavity effusions, although rare cases with solid masses are described.

Human herpes virus 8 (Kaposi’s sarcoma herpesvirus)

Oral Oncology ◽  
1998 ◽  
Vol 34 (1) ◽  
pp. 5-14 ◽  
Author(s):  
S.R Porter ◽  
L Di Alberti ◽  
N Kumar
Keyword(s):  
Kaposi's Sarcoma ◽  
Herpes Virus ◽  
Kaposi’S Sarcoma ◽  
Human Herpes ◽  
Human Herpes Virus 8 ◽  
Human Herpes Virus ◽  
Herpès Virus

scholarly journals Epidemiology of Human Herpes Virus 8 in Pregnant Women and their Newborns - A cross-sectional delivery survey in Central Gabon

2015 ◽  
Vol 39 ◽  
pp. 16-19 ◽  
Author(s):  
Mesküre Capan-Melser ◽  
Ghyslain Mombo-Ngoma ◽  
Daisy Akerey-Diop ◽  
Arti Basra ◽  
Rella Manego-Zoleko ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Herpes Virus ◽  
Human Herpes ◽  
Cross Sectional ◽  
Human Herpes Virus 8 ◽  
Human Herpes Virus ◽  
Herpès Virus

La puntura di artropodi ematofagi quale possible cofattore nella trasmissione di HHV8 (Human Herpes Virus 8) e nell’espressione del sarcoma di Kaposi

2002 ◽  
Vol 13 (2) ◽  
pp. 71-88
Author(s):  
Bruno Arcà ◽  
Carlo Costantini ◽  
Mario Coluzzi ◽  
Valeria Ascoli ◽  
Daniela Manno ◽  
...  
Keyword(s):  
Herpes Virus ◽  
Human Herpes ◽  
Human Herpes Virus 8 ◽  
Human Herpes Virus ◽  
Herpès Virus
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