Detection of BK polyomavirus genotypes to predict the development of BK polyomavirus‐associated complications in kidney transplant recipients: A retrospective analysis

2021 ◽  
Author(s):  
Irene Muñoz‐Gallego ◽  
Nerea Díaz‐Madridano ◽  
Noelia Moral ◽  
Consuelo Pascual ◽  
Natalia Polanco ◽  
...  
Keyword(s):  
Retrospective Analysis ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Bk Polyomavirus

scholarly journals BK Polyomavirus Micro-RNAs: Time Course and Clinical Relevance in Kidney Transplant Recipients

Viruses ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 351
Author(s):  
Baptiste Demey ◽  
Véronique Descamps ◽  
Claire Presne ◽  
Francois Helle ◽  
Catherine Francois ◽  
...  
Keyword(s):  
Viral Replication ◽  
Kidney Transplant ◽  
Clinical Relevance ◽  
Graft Loss ◽  
First Year ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Post Transplantation ◽  
Bk Polyomavirus ◽  
Micro Rnas

Background: Kidney transplant recipients (KTRs) are exposed to a high risk of BK polyomavirus (BKPyV) replication, which in turn may lead to graft loss. Although the microRNAs (miRNAs) bkv-miR-B1-3p and bkv-miR-B1-5p are produced during the viral cycle, their putative value as markers of viral replication has yet to be established. In KTRs, the clinical relevance of the changes over time in BKPyV miRNA levels has not been determined. Methods: In a retrospective study, we analyzed 186 urine samples and 120 plasma samples collected from 67 KTRs during the first year post-transplantation. Using a reproducible, standardized, quantitative RT-PCR assay, we measured the levels of bkv-miR-B1-3p and bkv-miR-B1-5p (relative to the BKPyV DNA load). Results: Detection of the two miRNAs had low diagnostic value for identifying patients with DNAemia or for predicting DNAuria during follow-up. Seven of the 14 KTRs with a sustained BKPyV infection within the first year post-transplantation showed a progressive reduction in the DNA load and then a rapid disappearance of the miRNAs. DNA and miRNA loads were stable in the other seven KTRs. Conclusions: After the DNA-based diagnosis of BKPyV infection in KTRs, bkv-miR-B1-3p and bkv-miR-B1-5p levels in the urine might be valuable markers for viral replication monitoring and thus might help physicians to avoid an excessive reduction in the immunosuppressive regimen.

BK polyomavirus viremia and antibody responses of pediatric kidney transplant recipients in Finland

2018 ◽  
Vol 23 (1) ◽  
pp. e13324 ◽  
Author(s):  
Jenni Miettinen ◽  
Irmeli Lautenschlager ◽  
Fabian Weissbach ◽  
Marion Wernli ◽  
Eeva Auvinen ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Antibody Responses ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Bk Polyomavirus

Clinical utility of leflunomide for BK polyomavirus associated nephropathy in kidney transplant recipients: A multicenter retrospective study

2019 ◽  
Vol 21 (2) ◽  
pp. e13058 ◽  
Author(s):  
Nicolas Keller ◽  
Simon Duquennoy ◽  
Anne Conrad ◽  
Samira Fafi‐Kremer ◽  
Emmanuel Morelon ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Kidney Transplant ◽  
Clinical Utility ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Bk Polyomavirus

Role of the Early Association of a mTOR Inhibitor and Tacrolimus in BK Polyomavirus Infection in Kidney Transplant Recipients

2018 ◽  
Vol 102 ◽  
pp. S566
Author(s):  
Veronica Lopéz ◽  
Teresa Vazquez ◽  
Cristina Jironda ◽  
Mercedes Cabello ◽  
Juana Alonso ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Mtor Inhibitor ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Bk Polyomavirus

scholarly journals Impact on renal resistive index of diabetes in renal transplant donors and recipients: A retrospective analysis of 1827 kidney transplant recipients

2019 ◽  
Vol 21 (3) ◽  
pp. 382-389
Author(s):  
Jean‐Baptiste Freminville ◽  
Louis‐Marie Vernier ◽  
Jérome Roumy ◽  
Frédéric Patat ◽  
Philippe Gatault ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Retrospective Analysis ◽  
Kidney Transplant ◽  
Resistive Index ◽  
Renal Resistive Index ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients
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