Prophylactic oseltamivir during major seasonal influenza H1N1 outbreak might reduce both H1N1 and associated pulmonary aspergillosis in children undergoing haploidentical transplantation

2020 ◽  
Vol 22 (5) ◽  
Author(s):  
Sarita Rani Jaiswal ◽  
Gitali Bhagwati ◽  
Mayank Soni ◽  
Atul Thatai ◽  
Hemamalini Aiyer ◽  
...  
Keyword(s):  
Seasonal Influenza ◽  
Pulmonary Aspergillosis ◽  
Haploidentical Transplantation ◽  
H1n1 Outbreak ◽  
Influenza H1n1

scholarly journals Bleeding Follicular Conjunctivitis due to Influenza H1N1 Virus

2010 ◽  
Vol 2010 ◽  
pp. 1-2 ◽  
Author(s):  
Maria Jesus Lopez-Prats ◽  
Empar Sanz Marco ◽  
Juan Jose Hidalgo-Mora ◽  
Salvador Garcia-Delpech ◽  
Manuel Diaz-Llopis
Keyword(s):  
Seasonal Influenza ◽  
Medical Literature ◽  
H1n1 Virus ◽  
Documented Case ◽  
Virus Serotype ◽  
Microbiological Confirmation ◽  
Influenza H1n1 ◽  
Follicular Conjunctivitis

Influenza H1N1 or A virus is a new virus serotype capable of human-to-human transmission. This infection causes a flu syndrome similar to that of seasonal influenza, with only one case of conjunctivitis described and no clinical details or microbiological confirmation. Its diagnosis is performed by PCR of pharyngeal smear of the patients affected. We report the first well-documented case in the medical literature of conjunctivitis by H1N1 virus.

scholarly journals Viral surface geometry shapes influenza and coronavirus spike evolution through antibody pressure

2020 ◽  
Author(s):  
Assaf Amitai
Keyword(s):  
Antibody Response ◽  
Computational Models ◽  
Seasonal Influenza ◽  
H1n1 Pandemic ◽  
Surface Geometry ◽  
Antigenic Sites ◽  
2009 H1n1 ◽  
Viral Surface ◽  
Over Time ◽  
Influenza H1n1

The evolution of circulating viruses is shaped by their need to evade antibody response, which mainly targets the glycoprotein (spike). However, not all antigenic sites are targeted equally by antibodies, leading to complex immunodominance patterns. We used 3D computational models to estimate antibody pressure on the seasonal influenza H1N1 and SARS spikes. Analyzing publically available sequences, we show that antibody pressure, through the geometrical organization of spikes on the viral surface, shaped their mutability. Studying the mutability patterns of SARS-CoV-2 and the 2009 H1N1 pandemic spikes, we find that they are not predominantly shaped by antibody pressure. However, for SARS-CoV-2, we find that over time, it acquired mutations at antibody-accessible positions, which could indicate possible escape as define by our model. We offer a geometry-based approach to predict and rank the probability of surface resides of SARS-CoV-2 spike to acquire antibody escaping mutations.

The role of seasonal influenza vaccination in preventing pandemic 2009 influenza (H1N1) during a school outbreak

2010 ◽  
Vol 49 (3) ◽  
pp. 225-226
Author(s):  
Li-Juan Liu ◽  
Xiao-Ai Zhang ◽  
Mao-Ti Wei ◽  
Cui He ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Influenza Vaccination ◽  
Seasonal Influenza ◽  
Seasonal Influenza Vaccination ◽  
Influenza H1n1

scholarly journals Microneutralization Assay Titres Correlate with Protection against Seasonal Influenza H1N1 and H3N2 in Children

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0131531 ◽  
Author(s):  
Chris P. Verschoor ◽  
Pardeep Singh ◽  
Margaret L. Russell ◽  
Dawn M. E. Bowdish ◽  
Angela Brewer ◽  
...  
Keyword(s):  
Seasonal Influenza ◽  
Microneutralization Assay ◽  
Influenza H1n1

scholarly journals Oseltamivir induced sinus bradycardia: an area of potential concern

2018 ◽  
Vol 8 (1) ◽  
pp. 162
Author(s):  
Karan B. Shah ◽  
Bhavesh S. Shah ◽  
Supriya D. Malhotra ◽  
Pankaj R. Patel
Keyword(s):  
Side Effects ◽  
Drug Administration ◽  
Seasonal Influenza ◽  
Sinus Bradycardia ◽  
Case Series ◽  
Swine Flu ◽  
Cardiovascular Side Effects ◽  
The World ◽  
Prevention And Treatment ◽  
Influenza H1n1

Oseltamivir was approved for the prevention and treatment of influenza in 1999 by the USFDA (US Food and Drug Administration). The use of Oseltamivir is increasing rapidly all over the world, especially after the 2009 “Swine Flu” pandemic. Less data is published as far as the cardiovascular side effects of Oseltamivir are concerned, but it could be associated with some serious cardiovascular side effects. This study presented a case series of 5 cases suspected to be suffering from seasonal influenza H1N1 (“Swine Flu”), who developed sinus bradycardia while they were on Oseltamivir therapy.

scholarly journals Correction: Microneutralization Assay Titres Correlate with Protection against Seasonal Influenza H1N1 and H3N2 in Children

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0163830 ◽  
Author(s):  
Chris P. Verschoor ◽  
Pardeep Singh ◽  
Margaret L. Russell ◽  
Dawn M. E. Bowdish ◽  
Angela Brewer ◽  
...  
Keyword(s):  
Seasonal Influenza ◽  
Microneutralization Assay ◽  
Influenza H1n1

COVID-19. Scenarios of a superfluous crisis

Kybernetes ◽  
2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Steffen Roth ◽  
Lars Clausen ◽  
Sören Möller
Keyword(s):  
Design Methodology ◽  
Seasonal Influenza ◽  
Critical Role ◽  
Case Fatality ◽  
Content Type ◽  
Hospitalised Patients ◽  
The Common ◽  
The Uk ◽  
Early Phases ◽  
Influenza H1n1

Purpose This study aims to highlight the critical role case fatality rates (CFR) have played in the emergence and the management of particularly the early phases of the current coronavirus crisis. Design/methodology/approach The study presents a contrastive map of CFR for the coronavirus (SARS-CoV-2) and influenza (H1N1 and H2N2). Findings The mapped data shows that current CFR of SARS-CoV-2 are considerably lower than, or similar to those, of hospitalised patients in the UK, Spain, Germany or international samples. The authors therefore infer a possible risk that the virulence of the coronavirus is considerably overestimated because of sampling biases, and that increased testing might reduce the general CFR of SARS-CoV-2 to rates similar to, or lower than, of the common seasonal influenza. Originality/value This study concludes that governments, health corporations and health researchers must prepare for scenarios in which the affected populations cease to believe in the statistical foundations of the current coronavirus crisis and interventions.

Sequence and phylogenetic analyses of neuraminidase gene of Iranian seasonal influenza H1N1 viruses from 2005–2009 and corresponding vaccine strains

2010 ◽  
Vol 54 (3) ◽  
pp. 205-210
Author(s):  
N. Z. SHAFIEI_JANDAGHI ◽  
T. MOKHTARI_AZAD ◽  
S. A. NADJI ◽  
J. YAVARIAN ◽  
M. NASERI ◽  
...  
Keyword(s):  
Seasonal Influenza ◽  
Phylogenetic Analyses ◽  
Influenza H1n1
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