Sequence and phylogenetic analyses of neuraminidase gene of Iranian seasonal influenza H1N1 viruses from 2005–2009 and corresponding vaccine strains

2010 ◽  
Vol 54 (3) ◽  
pp. 205-210
Author(s):  
N. Z. SHAFIEI_JANDAGHI ◽  
T. MOKHTARI_AZAD ◽  
S. A. NADJI ◽  
J. YAVARIAN ◽  
M. NASERI ◽  
...  
Keyword(s):  
Seasonal Influenza ◽  
Phylogenetic Analyses ◽  
Influenza H1n1

scholarly journals Bleeding Follicular Conjunctivitis due to Influenza H1N1 Virus

2010 ◽  
Vol 2010 ◽  
pp. 1-2 ◽  
Author(s):  
Maria Jesus Lopez-Prats ◽  
Empar Sanz Marco ◽  
Juan Jose Hidalgo-Mora ◽  
Salvador Garcia-Delpech ◽  
Manuel Diaz-Llopis
Keyword(s):  
Seasonal Influenza ◽  
Medical Literature ◽  
H1n1 Virus ◽  
Documented Case ◽  
Virus Serotype ◽  
Microbiological Confirmation ◽  
Influenza H1n1 ◽  
Follicular Conjunctivitis

Influenza H1N1 or A virus is a new virus serotype capable of human-to-human transmission. This infection causes a flu syndrome similar to that of seasonal influenza, with only one case of conjunctivitis described and no clinical details or microbiological confirmation. Its diagnosis is performed by PCR of pharyngeal smear of the patients affected. We report the first well-documented case in the medical literature of conjunctivitis by H1N1 virus.

scholarly journals Viral surface geometry shapes influenza and coronavirus spike evolution through antibody pressure

2020 ◽  
Author(s):  
Assaf Amitai
Keyword(s):  
Antibody Response ◽  
Computational Models ◽  
Seasonal Influenza ◽  
H1n1 Pandemic ◽  
Surface Geometry ◽  
Antigenic Sites ◽  
2009 H1n1 ◽  
Viral Surface ◽  
Over Time ◽  
Influenza H1n1

The evolution of circulating viruses is shaped by their need to evade antibody response, which mainly targets the glycoprotein (spike). However, not all antigenic sites are targeted equally by antibodies, leading to complex immunodominance patterns. We used 3D computational models to estimate antibody pressure on the seasonal influenza H1N1 and SARS spikes. Analyzing publically available sequences, we show that antibody pressure, through the geometrical organization of spikes on the viral surface, shaped their mutability. Studying the mutability patterns of SARS-CoV-2 and the 2009 H1N1 pandemic spikes, we find that they are not predominantly shaped by antibody pressure. However, for SARS-CoV-2, we find that over time, it acquired mutations at antibody-accessible positions, which could indicate possible escape as define by our model. We offer a geometry-based approach to predict and rank the probability of surface resides of SARS-CoV-2 spike to acquire antibody escaping mutations.

The role of seasonal influenza vaccination in preventing pandemic 2009 influenza (H1N1) during a school outbreak

2010 ◽  
Vol 49 (3) ◽  
pp. 225-226
Author(s):  
Li-Juan Liu ◽  
Xiao-Ai Zhang ◽  
Mao-Ti Wei ◽  
Cui He ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Influenza Vaccination ◽  
Seasonal Influenza ◽  
Seasonal Influenza Vaccination ◽  
Influenza H1n1

scholarly journals Microneutralization Assay Titres Correlate with Protection against Seasonal Influenza H1N1 and H3N2 in Children

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0131531 ◽  
Author(s):  
Chris P. Verschoor ◽  
Pardeep Singh ◽  
Margaret L. Russell ◽  
Dawn M. E. Bowdish ◽  
Angela Brewer ◽  
...  
Keyword(s):  
Seasonal Influenza ◽  
Microneutralization Assay ◽  
Influenza H1n1

scholarly journals Oseltamivir induced sinus bradycardia: an area of potential concern

2018 ◽  
Vol 8 (1) ◽  
pp. 162
Author(s):  
Karan B. Shah ◽  
Bhavesh S. Shah ◽  
Supriya D. Malhotra ◽  
Pankaj R. Patel
Keyword(s):  
Side Effects ◽  
Drug Administration ◽  
Seasonal Influenza ◽  
Sinus Bradycardia ◽  
Case Series ◽  
Swine Flu ◽  
Cardiovascular Side Effects ◽  
The World ◽  
Prevention And Treatment ◽  
Influenza H1n1

Oseltamivir was approved for the prevention and treatment of influenza in 1999 by the USFDA (US Food and Drug Administration). The use of Oseltamivir is increasing rapidly all over the world, especially after the 2009 “Swine Flu” pandemic. Less data is published as far as the cardiovascular side effects of Oseltamivir are concerned, but it could be associated with some serious cardiovascular side effects. This study presented a case series of 5 cases suspected to be suffering from seasonal influenza H1N1 (“Swine Flu”), who developed sinus bradycardia while they were on Oseltamivir therapy.

scholarly journals Correction: Microneutralization Assay Titres Correlate with Protection against Seasonal Influenza H1N1 and H3N2 in Children

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0163830 ◽  
Author(s):  
Chris P. Verschoor ◽  
Pardeep Singh ◽  
Margaret L. Russell ◽  
Dawn M. E. Bowdish ◽  
Angela Brewer ◽  
...  
Keyword(s):  
Seasonal Influenza ◽  
Microneutralization Assay ◽  
Influenza H1n1

COVID-19. Scenarios of a superfluous crisis

Kybernetes ◽  
2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Steffen Roth ◽  
Lars Clausen ◽  
Sören Möller
Keyword(s):  
Design Methodology ◽  
Seasonal Influenza ◽  
Critical Role ◽  
Case Fatality ◽  
Content Type ◽  
Hospitalised Patients ◽  
The Common ◽  
The Uk ◽  
Early Phases ◽  
Influenza H1n1

Purpose This study aims to highlight the critical role case fatality rates (CFR) have played in the emergence and the management of particularly the early phases of the current coronavirus crisis. Design/methodology/approach The study presents a contrastive map of CFR for the coronavirus (SARS-CoV-2) and influenza (H1N1 and H2N2). Findings The mapped data shows that current CFR of SARS-CoV-2 are considerably lower than, or similar to those, of hospitalised patients in the UK, Spain, Germany or international samples. The authors therefore infer a possible risk that the virulence of the coronavirus is considerably overestimated because of sampling biases, and that increased testing might reduce the general CFR of SARS-CoV-2 to rates similar to, or lower than, of the common seasonal influenza. Originality/value This study concludes that governments, health corporations and health researchers must prepare for scenarios in which the affected populations cease to believe in the statistical foundations of the current coronavirus crisis and interventions.

scholarly journals Circulation patterns of human seasonal Influenza A viruses in Chile before H1N1pdm09 pandemic

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Juan Mena ◽  
Rodrigo Tapia ◽  
Claudio Verdugo ◽  
Luis Avendaño ◽  
Paulina Parra-Castro ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Influenza A ◽  
Seasonal Influenza ◽  
Phylogenetic Analyses ◽  
Influenza Viruses ◽  
Surveillance Systems ◽  
Influenza A Viruses ◽  
Evolutionary Patterns ◽  
Public Health Decision ◽  
Health Decision

AbstractUnderstanding the diversity and circulation dynamics of seasonal influenza viruses is key to public health decision-making. The limited genetic information of pre-pandemic seasonal IAVs in Chile has made it difficult to accurately reconstruct the phylogenetic relationships of these viruses within the country. The objective of this study was to determine the genetic diversity of pre-pandemic human seasonal IAVs in Chile. We sequenced the complete genome of 42 historic IAV obtained between 1996 and 2007. The phylogeny was determined using HA sequences and complemented using other segments. Time-scale phylogenetic analyses revealed that the diversity of pre-pandemic human seasonal IAVs in Chile was influenced by continuous introductions of new A/H1N1 and A/H3N2 lineages and constant viral exchange between Chile and other countries every year. These results provide important knowledge about genetic diversity and evolutionary patterns of pre-pandemic human seasonal IAVs in Chile, which can help design optimal surveillance systems and prevention strategies. However, future studies with current sequences should be conducted.

scholarly journals Genetic Characterization of Influenza A Viruses in Japanese Swine in 2015 to 2019

2020 ◽  
Vol 94 (14) ◽  
Author(s):  
Junki Mine ◽  
Yuko Uchida ◽  
Nobuhiro Takemae ◽  
Takehiko Saito
Keyword(s):  
Influenza A ◽  
Seasonal Influenza ◽  
Phylogenetic Analyses ◽  
Antigenic Site ◽  
Influenza Viruses ◽  
Current Status ◽  
Single Mutation ◽  
Influenza A Viruses ◽  
Farm Level ◽  
Multiple Introductions

ABSTRACT To assess the current status of influenza A viruses of swine (IAVs-S) throughout Japan and to investigate how these viruses persisted and evolve on pig farms, we genetically characterized IAVs-S isolated during 2015 to 2019. Nasal swab samples collected through active surveillance and lung tissue samples collected for diagnosis yielded 424 IAVs-S, comprising 78 H1N1, 331 H1N2, and 15 H3N2 viruses, from farms in 21 sampled prefectures in Japan. Phylogenetic analyses of surface genes revealed that the 1A.1 classical swine H1 lineage has evolved uniquely since the late 1970s among pig populations in Japan. During 2015 to 2019, A(H1N1)pdm09 viruses repeatedly became introduced into farms and reassorted with endemic H1N2 and H3N2 IAVs-S. H3N2 IAVs-S isolated during 2015 to 2019 formed a clade that originated from 1999–2000 human seasonal influenza viruses; this situation differs from previous reports, in which H3N2 IAVs-S derived from human seasonal influenza viruses were transmitted sporadically from humans to swine but then disappeared without becoming established within the pig population. At farms where IAVs-S were frequently isolated for at least 3 years, multiple introductions of IAVs-S with phylogenetically distinct hemagglutinin (HA) genes occurred. In addition, at one farm, IAVs-S derived from a single introduction persisted for at least 3 years and carried no mutations at the deduced antigenic sites of the hemagglutinin protein, except for one at the antigenic site (Sa). Our results extend our understanding regarding the status of IAVs-S currently circulating in Japan and how they genetically evolve at the farm level. IMPORTANCE Understanding the current status of influenza A viruses of swine (IAVs-S) and their evolution at the farm level is important for controlling these pathogens. Efforts to monitor IAVs-S during 2015 to 2019 yielded H1N1, H1N2, and H3N2 viruses. H1 genes in Japanese swine formed a unique clade in the classical swine H1 lineage of 1A.1, and H3 genes originating from 1999–2000 human seasonal influenza viruses appear to have become established among Japanese swine. A(H1N1)pdm09-derived H1 genes became introduced repeatedly and reassorted with endemic IAVs-S, resulting in various combinations of surface and internal genes among pig populations in Japan. At the farm level, multiple introductions of IAVs-S with phylogenetically distinct HA sequences occurred, or IAVs-S derived from a single introduction have persisted for at least 3 years with only a single mutation at the antigenic site of the HA protein. Continued monitoring of IAVs-S is necessary to update and maximize control strategies.

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