Detection of antibodies to duck tembusu virus in human population with or without the history of contact with ducks

2021 ◽  
Author(s):  
Rojjanaporn Pulmanausahakul ◽  
Kunjimas Ketsuwan ◽  
Thitigun Jaimipuk ◽  
Duncan R. Smith ◽  
Prasert Auewarakul ◽  
...  
Keyword(s):  
Human Population ◽  
Duck Tembusu Virus ◽  
History Of ◽  
Tembusu Virus

scholarly journals Cloning, Analysis and Anti-Duck Tembusu Virus Innate Immune Response of Cherry Valley Duck TRIM32

2021 ◽  
pp. 101048
Author(s):  
Tianxu Li ◽  
Xiaofang Hu ◽  
Tingting Zhang ◽  
Xingdong Song ◽  
Huihui Zhang ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Duck Tembusu Virus ◽  
Cherry Valley Duck ◽  
Tembusu Virus

scholarly journals Duck Tembusu virus exhibits neurovirulence in BALB/c mice

2013 ◽  
Vol 10 (1) ◽  
pp. 260 ◽  
Author(s):  
Shuang Li ◽  
Xiaoxia Li ◽  
Lijiao Zhang ◽  
Yongyue Wang ◽  
Xiuling Yu ◽  
...  
Keyword(s):  
Duck Tembusu Virus ◽  
Tembusu Virus

scholarly journals Denisovan ancestry and population history of early East Asians

2020 ◽  
Author(s):  
Diyendo Massilani ◽  
Laurits Skov ◽  
Mateja Hajdinjak ◽  
Byambaa Gunchinsuren ◽  
Damdinsuren Tseveendorj ◽  
...  
Keyword(s):  
Gene Flow ◽  
Human Population ◽  
Modern Human ◽  
Population History ◽  
East Asians ◽  
Aboriginal Australians ◽  
North East ◽  
History Of ◽  
Female Member ◽  
Admixture Event

AbstractWe present analyses of the genome of a ~34,000-year-old hominin skull cap discovered in the Salkhit Valley in North East Mongolia. We show that this individual was a female member of a modern human population that, following the split between East and West Eurasians, experienced substantial gene flow from West Eurasians. Both she and a 40,000-year-old individual from Tianyuan outside Beijing carried genomic segments of Denisovan ancestry. These segments derive from the same Denisovan admixture event(s) that contributed to present-day mainland Asians but are distinct from the Denisovan DNA segments in present-day Papuans and Aboriginal Australians.

Effects of Aedes aegypti salivary protein on duck Tembusu virus replication and transmission in salivary glands

Acta Tropica ◽  
2022 ◽  
pp. 106310
Author(s):  
Chalida Sri-in ◽  
Aunyaratana Thontiravong ◽  
Lyric C. Bartholomay ◽  
Sonthaya Tiawsirisup
Keyword(s):  
Aedes Aegypti ◽  
Salivary Glands ◽  
Virus Replication ◽  
Salivary Protein ◽  
Duck Tembusu Virus ◽  
Tembusu Virus

scholarly journals The dynamic distribution of duck Tembusu virus in the spleen of infected shelducks

2019 ◽  
Vol 15 (1) ◽  
Author(s):  
Xuejing Sun ◽  
Enxue Liu ◽  
Adeela Iqbal ◽  
Taozhi Wang ◽  
Xindong Wang ◽  
...  
Keyword(s):  
Dynamic Distribution ◽  
Duck Tembusu Virus ◽  
Tembusu Virus

scholarly journals pUC18-CpG Is an Effective Adjuvant for a Duck Tembusu Virus Inactivated Vaccine

Viruses ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 238 ◽  
Author(s):  
Xiao Ren ◽  
Xiaolei Wang ◽  
Shan Zhang ◽  
Xintao Gao ◽  
Lichun Fang ◽  
...  
Keyword(s):  
Protective Immunity ◽  
Protective Efficacy ◽  
Vaccine Dose ◽  
Economic Losses ◽  
Control Group ◽  
Serum Cytokines ◽  
Duck Tembusu Virus ◽  
Antibody Titers ◽  
Protection Efficacy ◽  
Tembusu Virus

Duck Tembusu virus (DTMUV) is an emerging pathogenic flavivirus responsible for massive economic losses in the duck industry. However, commercially inactivated DTMUV vaccines have been ineffective at inducing protective immunity in ducks. The widely used adjuvant cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODNs) reportedly improve humoral and cellular immunities in animal models. However, its effectiveness in DTMUV vaccines requires validation. Here, we assessed the protective efficacy of pUC18-CpG as an adjuvant in an inactivated live DTMUV vaccine in ducks. Our results revealed that the serum hemagglutination inhibition (HI) antibody titers, positive rates of anti-DTMUV antibodies, the concentration of serum cytokines, and protection efficacy were significantly increased in ducks immunized with pUC18-CpG compared to that in the control group. Moreover, ducks immunized with a full vaccine dose containing a half dose of antigen supplemented with 40 μg of pUC18-CpG exhibited the most potent responses. This study suggests that pUC18-CpG is a promising adjuvant against DTMUV, which might prove effective in treating other viral diseases in waterfowl.

Development of an attenuated live vaccine candidate of duck Tembusu virus strain

2019 ◽  
Vol 231 ◽  
pp. 218-225 ◽  
Author(s):  
Dalin He ◽  
Xin Zhang ◽  
Lin Chen ◽  
Yi Tang ◽  
Youxiang Diao
Keyword(s):  
Virus Strain ◽  
Vaccine Candidate ◽  
Live Vaccine ◽  
Duck Tembusu Virus ◽  
Tembusu Virus
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