The impact of changing farm structure on foot‐and‐mouth disease spread and control: A simulation study

2020 ◽  
Vol 67 (4) ◽  
pp. 1633-1644 ◽  
Author(s):  
Tariq Halasa ◽  
Michael P. Ward ◽  
Anette Boklund
Keyword(s):  
Simulation Study ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Disease Spread ◽  
Farm Structure ◽  
Foot And Mouth ◽  
And Control ◽  
The Impact

scholarly journals A47 Reconstructing the evolutionary history of pandemic foot-and-mouth disease viruses: The impact of recombination within the emerging O/ME-SA/Ind-2001 lineage

2019 ◽  
Vol 5 (Supplement_1) ◽  
Author(s):  
K Bachanek-Bankowska ◽  
A Di Nardo ◽  
J Wadsworth ◽  
D King ◽  
N Knowles
Keyword(s):  
Sequence Data ◽  
Indian Subcontinent ◽  
Far East ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Economic Consequences ◽  
Disease Spread ◽  
Foot And Mouth ◽  
History Of ◽  
The Impact

Abstract Foot-and-mouth disease (FMD) is a highly contagious disease of livestock affecting animal production and trade throughout Asia and Africa. Understanding FMD virus (FMDV) global movements and evolution can help to reconstruct the disease spread between endemic regions and predict the risks of incursion into FMD-free countries. Global expansion of a single FMDV lineage is rare but can result in severe economic consequences. Using extensive sequence data, we have reconstructed the global space-time transmission history of the O/ME-SA/Ind-2001 lineage (which normally circulates in the Indian sub-continent) providing evidence of at least fifteen independent escapes during 2013–7 that have led to outbreaks in North Africa, the Middle East, Southeast Asia, and the Far East and the FMD-free islands of Mauritius. We demonstrated that sequence heterogeneity of this emerging FMDV lineage is accommodated within two co-evolving divergent sublineages, and that recombination by exchange of capsid-coding sequences can impact upon the reconstructed evolutionary histories. Thus, we recommend that only sequences encoding the outer capsid proteins should be used for broad-scale phylogeographical reconstruction. These data emphasize the importance of the Indian subcontinent as a source of FMDV that can spread across large distances and illustrates the impact of FMDV genome recombination on FMDV molecular epidemiology.

scholarly journals BENEFITS OF AN ANIMAL TRACEABILITY SYSTEM FOR A FOOT-AND-MOUTH DISEASE OUTBREAK: A SUPPLY-DRIVEN SOCIAL ACCOUNTING MATRIX APPROACH

2017 ◽  
Vol 49 (3) ◽  
pp. 438-466 ◽  
Author(s):  
MAN-KEUN KIM ◽  
C. MICHAEL UKKESTAD ◽  
HERNAN A. TEJEDA ◽  
DEEVON BAILEY
Keyword(s):  
Foot And Mouth Disease ◽  
The United States ◽  
Mouth Disease ◽  
Disease Spread ◽  
Social Accounting Matrix ◽  
Social Accounting ◽  
Traceability System ◽  
Spread Model ◽  
Foot And Mouth ◽  
The Impact

AbstractThis study reports the findings for an analysis using the computer program NAADSM (North American Animal Disease Spread Model) and a supply-driven social accounting matrix to examine the impact of a hypothetical foot-and-mouth disease (FMD) outbreak in a relatively isolated part of the United States, Utah, under various levels of livestock traceability. The analysis demonstrates that a significant regional economic impact in Utah would result from an FMD outbreak but that improved levels of traceability would be very important in helping to reduce the negative economic consequences of the outbreak.

scholarly journals Novel antibody binding determinants on the capsid surface of serotype O foot-and-mouth disease virus

2014 ◽  
Vol 95 (5) ◽  
pp. 1104-1116 ◽  
Author(s):  
Amin S. Asfor ◽  
Sasmita Upadhyaya ◽  
Nick J. Knowles ◽  
Donald P. King ◽  
David J. Paton ◽  
...  
Keyword(s):  
Amino Acid ◽  
Guinea Pig ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Amino Acid Residues ◽  
Serotype O ◽  
Antigenic Sites ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
The Impact

Five neutralizing antigenic sites have been described for serotype O foot-and-mouth disease viruses (FMDV) based on monoclonal antibody (mAb) escape mutant studies. However, a mutant virus selected to escape neutralization of mAb binding at all five sites was previously shown to confer complete cross-protection with the parental virus in guinea pig challenge studies, suggesting that amino acid residues outside the mAb binding sites contribute to antibody-mediated in vivo neutralization of FMDV. Comparison of the ability of bovine antisera to neutralize a panel of serotype O FMDV identified three novel putative sites at VP2-74, VP2-191 and VP3-85, where amino acid substitutions correlated with changes in sero-reactivity. The impact of these positions was tested using site-directed mutagenesis to effect substitutions at critical amino acid residues within an infectious copy of FMDV O1 Kaufbeuren (O1K). Recovered viruses containing additional mutations at VP2-74 and VP2-191 exhibited greater resistance to neutralization with both O1K guinea pig and O BFS bovine antisera than a virus that was engineered to include only mutations at the five known antigenic sites. The changes at VP2-74 and VP3-85 are adjacent to critical amino acids that define antigenic sites 2 and 4, respectively. However VP2-191 (17 Å away from VP2-72), located at the threefold axis and more distant from previously identified antigenic sites, exhibited the most profound effect. These findings extend our knowledge of the surface features of the FMDV capsid known to elicit neutralizing antibodies, and will improve our strategies for vaccine strain selection and rational vaccine design.

scholarly journals Synthetic peptide vaccine for Foot-and-Mouth Disease: synthesis, characterization and immunogenicity

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Banu Mansuroğlu ◽  
Serap Derman ◽  
Kadriye Kızılbey ◽  
Sezen Canım Ateş ◽  
Zeynep Mustafaeva Akdeste
Keyword(s):  
Synthetic Peptide ◽  
General Pattern ◽  
Peptide Vaccine ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Water Soluble ◽  
Peptide Sequence ◽  
Free Peptide ◽  
Foot And Mouth ◽  
And Control

AbstractBackgroundThe conjugations of antigenic synthetic peptide sequences with carrier polymers have opened new possibilities for the treatment of diseases. In this study, 135–161 peptide sequence of VP1 capsid protein of Foot-and-Mouth Disease was cross-linked with P(VP-co-AA) copolymer by covalent conjugation using water-soluble carbodiimide at different ratio of components (γ=5, 7, 9, 11, 15) for the first time in the literature.Materials and methodsBioconjugates were characterized by gel permeation chromatography and fluorescence spectroscopy to identify occurrences of the conjugates. After characterization, γ=15 bioconjugate was determined as optimum conjugate for immunization studies and IC50 value is calculated as 1.227 mg/mL. By determining the nontoxic range, indirect ELISA were performed to evaluate the immune response elicited in balb/c mice by either peptide or P(VP-co-AA)-peptide bioconjugates (γ=15). Two injections were applied to each group and high immune responses were obtained against γ=15 conjugate compared to free peptide and control.Results and conclusionAt the end of 9-week, the general pattern of immunoreactivity was acquired as γ=15>>peptide>control. Peptide formulated in the conjugated form had higher antibody response than free peptide and control (p<0.01, for all in both cases), this conjugate formulation put forward the adjuvant activity of P(VP-co-AA) polymer.

Assessment of foot-and-mouth disease risk areas in mainland China based spatial multi-criteria decision analysis

2021 ◽  
Author(s):  
Wang Haoran ◽  
Xiao Jianhua ◽  
Ouyang Maolin ◽  
Gao Hongyan ◽  
Bie Jia ◽  
...  
Keyword(s):  
Risk Factors ◽  
Decision Analysis ◽  
Disease Risk ◽  
Mainland China ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Multi Criteria Decision Analysis ◽  
Foot And Mouth ◽  
Risk Areas ◽  
And Control

Abstract Background Foot-and-mouth disease (FMD) is a highly contagious viral disease of cloven-hoofed animals. As a transboundary animal disease, the prevention and control of FMD are important. This study was based on spatial multi-criteria decision analysis (MCDA) to assess FMD risk areas in mainland China. Ten risk factors were identified for constructing risk maps by scoring, and the analytic hierarchy process (AHP) was used to calculate the criteria weights of all factors. Different risk factors had different units and attributes, and fuzzy membership was used to standardize the risk factors. The weighted linear combination (WLC) and one-at-a-time (OAT) were used to obtain risk and uncertainty maps as well as to perform sensitivity analysis. Results Four major risk areas were identified in mainland China, including western (Xinjiang and Tibet), southern (Yunnan, Guizhou, Guangxi and Guangdong), northern (Gansu, Ningxia and Inner Mongolia), and eastern (Hebei, Henan, Anhui, Jiangsu and Shandong). We found spring as the main season for FMD outbreaks. Risk areas were associated with the distance to previous outbreak points, grazing areas and cattle density. Receiver operating characteristic (ROC) analysis indicated that the risk map had good predictive power (AUC = 0.8532). Conclusions These results can be used to delineate FMD risk areas in mainland China, and provinces can adopt the targeted preventive measures and control strategies.

scholarly journals The Effectiveness of a Foot and Mouth Disease Outbreak Control Programme in Thailand 2008–2015: Case Studies and Lessons Learned

2018 ◽  
Vol 5 (4) ◽  
pp. 101 ◽  
Author(s):  
Terdsak Yano ◽  
Sith Premashthira ◽  
Tosapol Dejyong ◽  
Sahatchai Tangtrongsup ◽  
Mo D. Salman
Keyword(s):  
Prevention And Control ◽  
Animal Movement ◽  
Foot And Mouth Disease ◽  
Control Programme ◽  
Mouth Disease ◽  
Lessons Learned ◽  
Control Measures ◽  
Prevention Measures ◽  
Foot And Mouth ◽  
And Control

Three Foot and Mouth Disease (FMD) outbreaks in northern Thailand that occurred during the implementation of the national FMD strategic plan in 2008–2015 are described to illustrate the lessons learned and to improve the prevention and control of future outbreaks. In 2008, during a FMD outbreak on a dairy farm, milk delivery was banned for 30 days. This was a part of movement management, a key strategy for FMD control in dairy farms in the area. In 2009, more than half the animals on a pig farm were affected by FMD. Animal quarantine and restricted animal movement played a key role in preventing the spread of FMD. In 2010, FMD infection was reported in a captive elephant. The suspected source of virus was a FMD-infected cow on the same premises. The infected elephant was moved to an elephant hospital that was located in a different province before the diagnosis was confirmed. FMD education was given to elephant veterinarians to promote FMD prevention and control strategies in this unique species. These three cases illustrate how differences in outbreak circumstances and species require the implementation of a variety of different FMD control and prevention measures. Control measures and responses should be customized in different outbreak situations.

Business Reactions to the 2001 Foot and Mouth Disease Outbreak in Scotland

2005 ◽  
Vol 20 (4) ◽  
pp. 372-388 ◽  
Author(s):  
Wendy Kenyon ◽  
Alana Gilbert
Keyword(s):  
Rural Areas ◽  
Foot And Mouth Disease ◽  
Tourism Industry ◽  
Mouth Disease ◽  
Contingency Planning ◽  
Panel Survey ◽  
Business Managers ◽  
Foot And Mouth ◽  
The Impact ◽  
Shed Light

The paper focuses on two aspects of the 2001 foot and mouth disease (FMD) outbreak in Scotland that have been largely ignored: first, business managers perceptions of the impact of FMD during and immediately after the outbreak; and second, reactions to the outbreak in terms of action taken by businesses and advice sought. A panel survey of non-farm businesses conducted in April, June and September of 2001 is analysed to shed light on these issues. We find that even at the time, the vast majority of businesses did not report any real impact, although businesses in rural areas and in the tourism industry were more likely to feel some impact - either positive or negative. We show that business managers appeared to favour private sources of advice, although some public sources were found to be very useful, and that some actions, such as increased advertising in tourism businesses, could be more effective than others, such as making redundancies. We conclude with a discussion of the implications of the findings for contingency planning in the event of future FMD outbreaks.

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