The novel HLA‐DRB1 *03:01:01:05 and ‐ DPB1 *04:02:01:21 alleles identified in patients with acute leukemia

HLA ◽  
2022 ◽  
Author(s):  
Hawys B. Williams ◽  
Thomas R. Turner ◽  
Charlotte A. Cambridge ◽  
Steven G. E. Marsh ◽  
Neema P. Mayor
Keyword(s):  
Acute Leukemia ◽  
The Novel

Genomic landscape of adult mixed phenotype acute leukemia (MPAL).

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 7023-7023 ◽  
Author(s):  
Kiyomi Morita ◽  
Feng Wang ◽  
Keyur Patel ◽  
Carlos E. Bueso-Ramos ◽  
Abdallah Abou Zahr ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Rna Sequencing ◽  
Promoter Methylation ◽  
Cell Receptor ◽  
Methylation Pattern ◽  
The Novel ◽  
Gene Expressions ◽  
Genomic Landscape ◽  
Genetic Profiles ◽  
Mixed Phenotype

7023 Background: MPAL is a rare subgroup of acute leukemia characterized by both myeloid and lymphoid phenotypes. Genetic basis of MPAL is not well understood. Methods: We studied 31 patients (pts) with MPAL (median age 53) that met 2008 WHO criteria. Bone marrow samples were studied by targeted capture sequencing of 295 genes (median 393x), RNA sequencing, and Infinium methylation EPIC array (Illumina). Mutational landscape was compared to 194 AML, 71 B-ALL, and 6 T-ALL cases. Promoter methylation pattern was compared to the data from 194 AML (TCGA), 505 B-ALL and 101 T-ALL cases (Nordlund et al. Genome Biology. 2013). Results: Eighteen (58%) pts had myeloid-T and 13 (42%) had myeloid-B phenotype. Four pts had t(9;22), 1 had 11q23 rarrangement, and 8 had complex karyotype. MPAL had similar number of mutations with AML but had higher number of mutations than B-ALL or T-ALL. Both AML-type and ALL-type mutations were detected in MPAL, supporting the mixed phenotypic features. However, NPM1, CEBPA and GATA2 mutations were specific to AML and were not found in MPAL. Myeloid-T and myeloid-B showed distinct patterns of mutations, in which DNMT3A, IDH2, NOTCH1, IL7R, and FBXW7 mutations were enriched in myeloid-T whereas RUNX1 mutations were enriched in myeloid-B. Myeloid-T and myeloid-B also showed distinct patterns of promoter methylation. Overall, myeloid-T had more hypermethylated CpG loci than myeloid-B. Genes that have essential role in T-cell receptor (TCR) pathway ( CD3D, CD7, CD247, LCK, PRKCQ, CCR9, and TCL1A) were differentially methylated and differentially expressed between myeloid-T and myeloid-B. RNA sequencing revealed several known translocations such as, NSD1-NUP98, and KMT2A-MLLT4, in addition to the novel fusion proteins such as FOXP1-DNAJC15, RUNX1-NAP1L1, and BCL2-TM9SF3. Unbiased hierarchical clustering of MPAL, AML, B-ALL and T-ALL by promoter methylation revealed that myeloid-T had consistent similarity with T-ALL, while myeloid-B showed random similarity with either B-ALL or AML. Conclusions: MPAL is genetically heterogeneous and myeloid-T and myeloid-B shows distinct patterns of mutations, methylation and gene expressions. Therapy for MPAL may need to be tailored based on the genetic profiles.

In vitro activity of the novel cytotoxic agent CHS 828 in childhood acute leukemia

2002 ◽  
Vol 13 (7) ◽  
pp. 735-742 ◽  
Author(s):  
B-M Frost ◽  
G Lönnerholm ◽  
P Nygren ◽  
R Larsson ◽  
E Lindhagen
Keyword(s):  
Acute Leukemia ◽  
Vitro Activity ◽  
Cytotoxic Agent ◽  
The Novel ◽  
In Vitro Activity ◽  
Chs 828 ◽  
Childhood Acute Leukemia

Abstract 5459: Preclinical efficacy of the novel PIM2 kinase inhibitor, JP_11646, in human acute leukemia models

2014 ◽  
Author(s):  
Krista E. Pundt ◽  
Carmen M. Baldino ◽  
Justin Caserta ◽  
Stephane Dumas ◽  
Yvonne Flanders ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Kinase Inhibitor ◽  
The Novel ◽  
Preclinical Efficacy

scholarly journals Cell cycle-dependent activity of the novel dual PI3K-MTORC1/2 inhibitor NVP-BGT226 in acute leukemia

2013 ◽  
Vol 12 (1) ◽  
pp. 46 ◽  
Author(s):  
Kerstin Kampa-Schittenhelm ◽  
Michael Heinrich ◽  
Figen Akmut ◽  
Katharina Rasp ◽  
Barbara Illing ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Acute Leukemia ◽  
The Novel ◽  
Dependent Activity ◽  
Cycle Dependent

Abstract A130: Targeting BMI-1 by the novel BMI-1 inhibitor PTC596 in acute leukemia

2015 ◽  
Author(s):  
Yuki Nishida ◽  
Aya Maeda ◽  
Liangxian Cao ◽  
Melissa Dumble ◽  
Shinya Kimura ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
The Novel

The novel steroidal glycoside from the dried bulb of Allium Macrostemon Bunge inhibits platelet activation

2010 ◽  
Vol 34 (8) ◽  
pp. S33-S33
Author(s):  
Wenchao Ou ◽  
Haifeng Chen ◽  
Yun Zhong ◽  
Benrong Liu ◽  
Keji Chen
Keyword(s):  
Platelet Activation ◽  
The Novel ◽  
Steroidal Glycoside ◽  
Allium Macrostemon
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