scholarly journals In elderly Caucasian women, younger facial perceived age correlates with better forearm skin microcirculation reactivity

2021 ◽  
Author(s):  
Christelle Guéré ◽  
Armelle Bigouret ◽  
Alex Nkengne ◽  
Katell Vié ◽  
Anthony Gélis ◽  
...  
Keyword(s):  
Skin Microcirculation ◽  
Forearm Skin ◽  
Perceived Age ◽  
Caucasian Women

scholarly journals P1161CUTANEOUS MICROCIRCULATORY DYSFUNCTION IN PERITONEAL DIALYSIS PATIENTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Jennifer Williams ◽  
Mark Gilchrist ◽  
Donald Fraser ◽  
David Strain ◽  
Angela Shore
Keyword(s):  
Peritoneal Dialysis ◽  
Statistical Significance ◽  
Microvascular Function ◽  
Healthy Controls ◽  
Dialysis Patients ◽  
Skin Microcirculation ◽  
Doppler Flowmetry ◽  
Microvascular Reactivity ◽  
Co Morbidity ◽  
Forearm Skin

Abstract Background and Aims Microvascular impairment is an early step in cardiovascular disease (CVD), the major cause of morbidity and mortality in patients with CKD. Changes in skin microvascular reactivity have been shown to reflect more widespread changes in the systemic and coronary microcirculation. Microvascular function is attenuated by advancing age and conditions that commonly coexist with CKD such as diabetes and hypertension. We investigated whether skin microvascular reactivity is impaired in peritoneal dialysis (PD) patients compared with healthy controls and whether this impairment is independent of comorbidity. Method Forearm skin vasculature was examined in 27 healthy controls, 27 patients on PD and 27 controls matched to the PD patients for age, gender, diabetes and previous CV events. Microvascular function was assessed using laser Doppler flowmetry in combination with post-occlusive reactive hyperaemia (a test of generalised microvascular function) and iontophoretic application of acetylcholine (ACh) and sodium nitroprusside (SNP) to investigate endothelium dependant and non-endothelium dependant vasodilation respectively. Results Peak post-occlusive flow was lower in the PD patients than in both the healthy controls and the co-morbidity matched group; 90.45 AU (60.9-128.35) in healthy controls, 73AU (58.8-134.4) in matched controls and 56.95AU (45.1-89.8) in PD patients (p=0.0239 healthy controls versus patients, p=0.0373 matched controls versus patients). SNP-mediated vasodilatation was statistically lower in the PD group compared with healthy controls (p= 0.016), ACh response was lower but did not reach statistical significance (p= 0.076). ACh and SNP-mediated vasodilatation trended towards being lower in PD patients than matched controls but did not reach statistical significance. Conclusion The PD patients were characterised by a generalised dysfunction of the skin microcirculation compared with healthy controls and controls matched for factors known to affect the microcirculation. This appears to be the result of impaired endothelium dependant and independent vasodilatory mechanisms.

Influence of facial skin attributes on the perceived age of Caucasian women

2008 ◽  
Vol 22 (8) ◽  
pp. 982-991 ◽  
Author(s):  
A Nkengne ◽  
C Bertin ◽  
GN Stamatas ◽  
A Giron ◽  
A Rossi ◽  
...  
Keyword(s):  
Facial Skin ◽  
Perceived Age ◽  
Caucasian Women

scholarly journals 103 Influence of cutaneous parameters on perceived age in senior caucasian women

2019 ◽  
Vol 139 (9) ◽  
pp. S232
Author(s):  
A. Bigouret ◽  
C. Guéré ◽  
R. Fitoussi ◽  
A. Nkengne ◽  
K. Vié
Keyword(s):  
Perceived Age ◽  
Caucasian Women

scholarly journals Increasing the diagnostic signifcance of the laser Doppler flowmetry in assessing skin microcirculation in hypertension

2019 ◽  
Vol 25 (1) ◽  
pp. 74-83 ◽  
Author(s):  
P. A. Glazkova ◽  
S. A. Terpigorev ◽  
D. A. Kulikov ◽  
N. A. Ivanova ◽  
A. A. Glazkov
Keyword(s):  
Healthy Volunteers ◽  
Laser Doppler Flowmetry ◽  
Local Heating ◽  
Relative Increase ◽  
Laser Doppler ◽  
Instrumental Method ◽  
Skin Microcirculation ◽  
Doppler Flowmetry ◽  
Forearm Skin ◽  
Heating Test

Background.Hypertension (HTN) is associated with impaired skin microcirculation. Laser Doppler flowmetry is an objective, quantitative, instrumental method that allows evaluating skin microcirculation. However, the method was not widely used clinically due to high variability of perfusion and small difference between healthy people and HTN patients and, as a consequence, low diagnostic signifcance.Objective.To provide the grounds for the approaches increasing the informative value of skin microcirculation measurement by laser Doppler flowmetry in HTN patients.Design and methods.The study involved HTN patients (n = 13, the median age was 60 (49; 63) years) and young otherwise healthy volunteers without HTN (n = 12, the median age 26 (25; 27) years). Microcirculation measurement was performed by laser Doppler flowmetry using LAKK-02 device. Registration of microcirculation on the forearm skin was carried out during the occlusionheating test. The Mann-Whitney test was used to compare the parameters in two groups. The diagnostic accuracy of the method for the inverse classifcation of the subjects was evaluated using ROC analysis.Results.In HTN patients, the median baseline perfusion was 3,1 (1,84; 4,31) perfusion units (PU), in healthy volunteers — 4,29 (3,66; 8,14) PU (p = 0,04). The median area under the microcirculation curve for the frst 2 minutes of heating in HTN patients was 1206,7 (813; 1449) PU × s, in healthy volunteers — 1552,3 (1310; 1624) PU × s (p = 0,035). In healthy volunteers, the heating increased the perfusion by 596 % (386%; 878%), and in HTN patients perfusion increased only by 265% (180 %; 318%) (p = 0,01). The relative increase in perfusion during postocclusion hyperemia with continued heating compared with the baseline in healthy volunteers was 651% (493 %; 999%), and in HTN patients — 302 % (182 %; 436%) (p = 0,005). Thus, when comparing the average parameters for each period in the occlusion-heating test, only basic perfusion showed signifcant differences. However, when changed from absolute to relative parameters (the increase in microcirculation in relation to the vasodilating effects), the difference was signifcant. Moreover, sensitivity achieved was 75 % and specifcity — 84,6% (the inverse classifcation of groups).Conclusions.The physiological (the local heating of the forearm skin at a rate of 2 degrees Celsius per second, a combination of vasodilating effects) and mathematical (the transition from absolute to relative values) approaches provided an increase of the informative value of the laser Doppler flowmetry, as well as its sensitivity and specifcity.

Differences in Foot and Forearm Skin Microcirculation in Diabetic Patients With and Without Neuropathy

Diabetes Care ◽  
1998 ◽  
Vol 21 (8) ◽  
pp. 1339-1344 ◽  
Author(s):  
S. Arora ◽  
P. Smakowski ◽  
R. G. Frykberg ◽  
L. R. Simeone ◽  
R. Freeman ◽  
...  
Keyword(s):  
Diabetic Patients ◽  
Skin Microcirculation ◽  
Forearm Skin

scholarly journals Variability of skin microcirculation in case of arterial hypertension from the view of distributional responses of blood flow

2016 ◽  
Vol 15 (2) ◽  
pp. 32-39
Author(s):  
A. P. Vasilev ◽  
N. N. Streltsova
Keyword(s):  
Arterial Hypertension ◽  
Peripheral Resistance ◽  
Individual Variability ◽  
The Other ◽  
Skin Microcirculation ◽  
Doppler Flowmetry ◽  
Vessel Area ◽  
Blood Filling ◽  
Forearm Skin ◽  
High Level

The aim of the study. To evaluate individual variability of skin microcirculation (MC) in patients with arterial hypertension (AH) and characteristics of microvascular (MV) reaction to hypotensive impact from the view of blood distribution. Material and methods. Microcirculation of forearm skin in 176 patients with AH stage 2 was studied by laser doppler flowmetry (LDF). All the patients were divided into 2 groups: 1 - with low (n=46) value of MV resistance and 2 - with high (n=130) value of MV resistance. 90 patients out of the total amount (also divided into the same 2 groups - 25 people in the first group and 65 people in the second) had another study of MC after sublingual taking of 20 mg of corinfar. Results. The results revealed controversial MC skin picture with high blood filling of MV canal and reduced MV tone in the first group and high value of MV tone with hemoperfusion limitation in the second group in patients with AH and the same blood pressure (BP). Reduction in the first group can be caused by redistribution of a minute blood volume kept on a high level in the condition of elevated total peripheral resistance (TPR) (the so called central blood bypass). In this case the skin where a part of a cardiac output goes to serves as a depot. Increase of intravascular resistance in the skin of patients from the second group is caused by prevalence of TPR in hemodynamic mechanisms of BP elevation. Whereas constriction of microcirculation vessel is observed not only in the abdominal vessel area (which is the main area responsible for TPR formation) but also in the other areas, particularly in the skin. Corresponding BP decrease in groups of patients under the influence of corinfar was accompanied by bidirectional shifts of MC values: vasodilation in the second group and vasoconstriction in the first group of patients. It happens due to more balanced bloodflow distribution in the vessel areas more responsible for TPR formation as a result of vasodilation under the influence of corinfar.

scholarly journals Low-pressure sequential compression of lower limbs enhances forearm skin blood flow

2016 ◽  
Vol 39 (6) ◽  
pp. 204 ◽  
Author(s):  
Guy Amah ◽  
Sebastian Voicu ◽  
Philippe Bonnin ◽  
Nathalie Kubis
Keyword(s):  
Blood Flow ◽  
Skin Blood Flow ◽  
Cardiac Cycle ◽  
Low Pressure ◽  
Lower Limbs ◽  
Test Results ◽  
Skin Microcirculation ◽  
Doppler Flowmetry ◽  
Non Invasive ◽  
Forearm Skin

Purpose: We investigated whether forearm skin blood flow could be improved when a multilayer pulsatile inflatable suit was applied at a low pressure to the lower limbs and abdomen. We hypothesized that a non-invasive purely mechanical stimulation of the lower limbs could induce remote forearm blood flow modifications. Methods: The pulsatile suit induced a sequential compartmentalized low compression (65 mmHg), which was synchronized with each diastole of the cardiac cycle with each phase evolving centripetally (lower limbs to abdomen). Modifications of the forearm skin blood flow were continuously recorded by laser Doppler flowmetry (LDF) at baseline and during the pulsatile suit application. Endothelium-dependent and endothelium-independent vasodilations of the forearm skin microcirculation were measured by LDF in response to a local transdermal iontophoretic application of acetylcholine (ACh-test) and to hyperthermia (hyperT- test). Results: Twenty-four healthy volunteers, 12 men and 12 women (43±14 years) were included in the study. LDF responses increased 1) under pulsatile suit (97±106%, p

Empirically Supported Risk Factors for Disordered Eating in Caucasian Women

2011 ◽  
Author(s):  
Annette S. Kluck ◽  
Lucy Johnson ◽  
Chenetra Bradley ◽  
Erin English
Keyword(s):  
Risk Factors ◽  
Disordered Eating ◽  
Empirically Supported ◽  
Caucasian Women
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