Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Display a Novel Interaction between P-Selectin and Galectin-1

2014 ◽  
Vol 80 (1) ◽  
pp. 12-21 ◽  
Author(s):  
H. Suila ◽  
T. Hirvonen ◽  
A. Kotovuori ◽  
I. Ritamo ◽  
E. Kerkelä ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Umbilical Cord Blood ◽  
Stromal Cells ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord

scholarly journals Parameters that influence the isolation of multipotent mesenchymal stromal cells from human umbilical cord blood

2013 ◽  
Vol 6 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Attiyeh Vasaghi ◽  
Atefeh Dehghani ◽  
Zeinab Khademalhosseini ◽  
Mohsen Khosravi Maharlooei ◽  
Ahmad Monabati ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Umbilical Cord Blood ◽  
Stromal Cells ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord

scholarly journals Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

Cells ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 1344
Author(s):  
Hyun Ah Oh ◽  
Jihye Kwak ◽  
Beom Joon Kim ◽  
Hye Jin Jin ◽  
Won Seok Park ◽  
...  
Keyword(s):  
Cord Blood ◽  
Conditioned Medium ◽  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Umbilical Cord Blood ◽  
Migration Inhibitory Factor ◽  
Stromal Cells ◽  
Hair Growth ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord

Conventional therapeutic applications of mesenchymal stromal cells (MSCs) focus on cell replacement and differentiation; however, increasing evidence suggests that most of their therapeutic effects are carried out by their various secretions. This study investigated the application of conditioned medium (CM) from human umbilical cord blood-derived MSCs (hUCB-MSCs) to improve hair growth and developed a method to reliably produce this optimized CM. Primed MSC-derived CM (P-CM) with combinations of TGF-β1 and LiCl was optimized by comparing its effects on the cell viability of dermal papilla cells (DPCs). P-CM significantly increased the viability of DPCs compared to CM. The secretion of vascular endothelial growth factor (VEGF) in DPCs was regulated by the macrophage migration inhibitory factor (MIF) in the P-CM secreted by MSCs. These findings suggest that P-CM can improve the efficacy in hair growth via a paracrine mechanism and that MIF in P-CM exerts hair growth-promoting effects via a VEGF-related β-catenin and p-GSK-3β [SER9] signaling pathway. Furthermore, clinical trials have shown that 5% P-CM improved androgenetic alopecia through producing an increased hair density, thickness, and growth rate, suggesting that this topical agent may be a novel and effective treatment option for patients with androgenetic alopecia.

Wound-healing potential of human umbilical cord blood–derived mesenchymal stromal cells in vitro—a pilot study

Cytotherapy ◽  
2015 ◽  
Vol 17 (11) ◽  
pp. 1506-1513 ◽  
Author(s):  
Hi-Jin You ◽  
Sik Namgoong ◽  
Seung-Kyu Han ◽  
Seong-Ho Jeong ◽  
Eun-Sang Dhong ◽  
...  
Keyword(s):  
Wound Healing ◽  
Pilot Study ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Umbilical Cord Blood ◽  
Stromal Cells ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord

Individual and combined effects of mesenchymal stromal cells and recombinant stimulatory cytokines on the in vitro growth of primitive hematopoietic cells from human umbilical cord blood

Cytotherapy ◽  
2009 ◽  
Vol 11 (7) ◽  
pp. 886-896 ◽  
Author(s):  
Patricia Flores-Guzmán ◽  
Eugenia Flores-Figueroa ◽  
Juan J. Montesinos ◽  
Guadalupe Martínez-Jaramillo ◽  
Veronica Fernández-Sánchez ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Umbilical Cord Blood ◽  
Stromal Cells ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Combined Effects ◽  
In Vitro Growth
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