scholarly journals Intraarterial transplantation of human umbilical cord blood mononuclear cells is more efficacious and safer compared with umbilical cord mesenchymal stromal cells in a rodent stroke model

2014 ◽  
Vol 5 (2) ◽  
pp. 45 ◽  
Author(s):  
Neha Karlupia ◽  
Nathan C Manley ◽  
Kameshwar Prasad ◽  
Richard Schäfer ◽  
Gary K Steinberg
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Stromal Cells ◽  
Mononuclear Cells ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Stroke Model ◽  
Blood Mononuclear Cells ◽  
Cord Blood Mononuclear Cells

scholarly journals Intravenous Versus Intraarterial Transplantation of Human Umbilical Cord Blood Mononuclear Cells for Brain Ischemia in Rats

2017 ◽  
Vol 24 (4) ◽  
pp. 187-194 ◽  
Author(s):  
Yetty Ramli ◽  
Ahmad Sulaiman Alwahdy ◽  
Mohammad Kurniawan ◽  
Berry Juliandi ◽  
Puspita Eka Wuyung ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Brain Ischemia ◽  
Umbilical Cord Blood ◽  
Mononuclear Cells ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Blood Mononuclear Cells ◽  
Cord Blood Mononuclear Cells

scholarly journals Electrophysiological, Morphological, and Ultrastructural Features of the Injured Spinal Cord Tissue after Transplantation of Human Umbilical Cord Blood Mononuclear Cells Genetically Modified with the VEGF and GDNF Genes

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Y. O. Mukhamedshina ◽  
Z. E. Gilazieva ◽  
S. S. Arkhipova ◽  
L. R. Galieva ◽  
E. E. Garanina ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Mononuclear Cells ◽  
Genetically Modified ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Blood Mononuclear Cells ◽  
Cord Blood Mononuclear Cells

In this study, we examined the efficacy of human umbilical cord blood mononuclear cells (hUCB-MCs), genetically modified with the VEGF and GDNF genes using adenoviral vectors, on posttraumatic regeneration after transplantation into the site of spinal cord injury (SCI) in rats. Thirty days after SCI, followed by transplantation of nontransduced hUCB-MCs, we observed an improvement inH(latency period, LP) andM(Amax)waves, compared to the group without therapy after SCI. For genetically modified hUCB-MCs, there was improvement inAmaxofMwave and LP of both theMandHwaves. The ratio betweenAmaxof theHandMwaves (Hmax/Mmax) demonstrated that transplantation into the area of SCI of genetically modified hUCB-MCs was more effective than nontransduced hUCB-MCs. Spared tissue and myelinated fibers were increased at day 30 after SCI and transplantation of hUCB-MCs in the lateral and ventral funiculi 2.5 mm from the lesion epicenter. Transplantation of hUCB-MCs genetically modified with the VEGF and GNDF genes significantly increased the number of spared myelinated fibers (22-fold,P>0.01) in the main corticospinal tract compared to the nontransduced ones. HNA+cells with the morphology of phagocytes and microglia-like cells were found as compact clusters or cell bridges within the traumatic cavities that were lined by GFAP+host astrocytes. Our results show that hUCB-MCs transplanted into the site of SCI improved regeneration and that hUCB-MCs genetically modified with the VEGF and GNDF genes were more effective than nontransduced hUCB-MCs.

Generation of clinical-grade red blood cells from human umbilical cord blood mononuclear cells

2018 ◽  
Vol 375 (2) ◽  
pp. 437-449 ◽  
Author(s):  
Suneel Rallapalli ◽  
Soma Guhathakurta ◽  
Shalini Narayan ◽  
Dillip Kumar Bishi ◽  
Venkatesh Balasubramanian ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Cells ◽  
Mononuclear Cells ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Clinical Grade ◽  
Blood Mononuclear Cells ◽  
Cord Blood Mononuclear Cells

scholarly journals Intra-arterial transplantation of human umbilical cord blood mononuclear cells in neonatal hypoxic–ischemic rats

Life Sciences ◽  
2014 ◽  
Vol 96 (1-2) ◽  
pp. 33-39 ◽  
Author(s):  
Samuel Greggio ◽  
Simone de Paula ◽  
Pâmella Nunes Azevedo ◽  
Gianina Teribele Venturin ◽  
Jaderson Costa DaCosta
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Mononuclear Cells ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Blood Mononuclear Cells ◽  
Cord Blood Mononuclear Cells
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