Extensive tissue necrosis of the tongue in a methamphetamine user: A case report

2021 ◽  
Author(s):  
Atsushi Shudo
Keyword(s):  
Case Report ◽  
Tissue Necrosis ◽  
Methamphetamine User

scholarly journals Combination therapy with bosentan and sildenafil for refractory digital ulcers and Raynaud’s phenomenon in a 30-year-old woman with systemic sclerosis: Case report and literature review

2019 ◽  
Vol 5 (2) ◽  
pp. 159-164 ◽  
Author(s):  
Jan-Gerd Rademacher ◽  
Chris Wincup ◽  
Björn Tampe ◽  
Peter Korsten
Keyword(s):  
Case Report ◽  
Systemic Sclerosis ◽  
Literature Review ◽  
Combination Therapy ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Digital Ulcers ◽  
Channel Blockers ◽  
Tissue Necrosis ◽  
Diffuse Systemic Sclerosis

Background: Systemic sclerosis is a rare autoimmune disease characterized by skin and organ fibrosis, and vasculopathy. Raynaud’s phenomenon is almost universally present in systemic sclerosis and can be the most debilitating symptom. Raynaud’s phenomenon may lead to the development of digital ulcers, potentially complicated by infection, tissue necrosis, and auto-amputation. Recommended treatments have variable efficacy. Methods: We report the case of a 30-year-old woman with diffuse systemic sclerosis suffering from severe Raynaud’s phenomenon and digital ulcers with digital tissue necrosis who was treated with combination therapy of an endothelin receptor antagonist and phosphodiesterase 5 inhibitor. In addition, we reviewed the literature on the topic. Results: Previous therapy with calcium-channel blockers, intravenous iloprost, and bosentan had all failed to control symptoms. We added sildenafil in combination with bosentan and observed a rapid and sustained treatment effect. Raynaud’s phenomenon severity, number of attacks, and attack duration decreased within 2 weeks of initiating treatment. Furthermore, this resulted in the healing of established digital ulcers. Conclusion: Our case report suggests that combination therapy may be a feasible treatment for the most severely affected and refractory patients. In our literature review, we found one retrospective study and three additional cases with similarly encouraging results.

Intranasal tissue necrosis associated with opioid abuse: Case report and systematic review

2017 ◽  
Vol 128 (8) ◽  
pp. 1767-1771
Author(s):  
Danielle A. Morrison ◽  
Sarah K. Wise ◽  
John M. DelGaudio ◽  
Naweed I. Chowdhury ◽  
Joshua M. Levy
Keyword(s):  
Systematic Review ◽  
Case Report ◽  
Opioid Abuse ◽  
Tissue Necrosis ◽  
Abuse Case

Brown recluse spider bite. A literature review and case report

1989 ◽  
Vol 79 (3) ◽  
pp. 142-146 ◽  
Author(s):  
M Gutowicz ◽  
RA Fritz ◽  
AL Sonoga
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Early Treatment ◽  
Clinical Presentation ◽  
Review Of The Literature ◽  
Tissue Necrosis ◽  
Future Studies ◽  
Treatment Regimens ◽  
Spider Bite ◽  
Treatment Prognosis

A review of the literature on brown recluse spider bite is presented, including clinical presentation and treatment. Emphasis is placed on the treatment of local tissue necrosis. A case report of a severe necrotic ulcer secondary to a spider bit is presented. Tissue necrosis following a brown recluse spider bit can be debilitating, and healing may be prolonged for many months. Even with early treatment, prognosis often is poor. Future studies might help establish better treatment regimens.

scholarly journals Deciduosis peritonei: A case report

2005 ◽  
Vol 58 (3-4) ◽  
pp. 196-199 ◽  
Author(s):  
Atila Fenjvesi ◽  
Slobodan Zivkovic
Keyword(s):  
Case Report ◽  
Metastatic Melanoma ◽  
Incidental Finding ◽  
Smooth Muscle Actin ◽  
Metastatic Carcinoma ◽  
Tissue Necrosis ◽  
Decidual Cells ◽  
Physiological Phenomenon ◽  
S 100 ◽  
Vacuolated Cytoplasm

Introduction The occurrence of ectopic decidua (deciduosis) has been observed most often in the ovaries, uterus, and cervix. It has been established in approximately 90% of patients who have undergone laparotomy during pregnancy. A peritoneal localization is less frequent and usually an asymptomatic incidental finding, but is occasionally associated with massive and potentially fatal hemoperitoneum, abdominal pain and dystocia. Ectopis decidua is a physiological phenomenon of pregnancy and arises from a progesterone-induced metaplasia of subserosal stromal cells. Case report A 32-year-old G1P1 female underwent cesarean section at 39 weeks gestation because of imminent fetal asphyxia. The laparotomy revealed a greyish-yellow soft nodule on the parietal peritoneum. On histologic examination the biopsy lesion was highly vascular and was composed of large polygonal decidualized cells with abundant eosinophilic, focally vacuolated cytoplasm. The nuclei were regular, with fine chromatin and inconspicuous nucleoli. Ectopic decidua was infiltrated by blood and surrounded with adipose tissue necrosis and mild chronic inflammation. Discussion and conclusion The differential diagnosis of peritoneal deciduosis included deciduoid mesothelioma, metastatic carcinoma (especially if decidual cells have a vacuolated cytoplasm mimicking signetring cells), and metastatic melanoma. Decidual cells showed immunoreactivity for vimentin and progesteron receptors and focal positivity for desmin and smooth muscle actin. The presence of cellular atypia, mitotic activity, and immunoreactivity for cy-tokeratin 5/6 and calretinin will assist in making the diagnosis of deciduoid mesothelioma. The diagnosis of metastatic carcinoma is assisted by the nuclear features and cytokeratin immunoreactivity. A positive immunostain for S-100 and/or HMB-45 will assist in the diagnosis of metastatic melanoma. .

Levamisole-Adulterated Cocaine Leading to Fatal Vasculitis: A Case Report

2017 ◽  
Vol 37 (4) ◽  
pp. 49-57 ◽  
Author(s):  
Belinda B. Hammond ◽  
Jordan Craven
Keyword(s):  
Blood Flow ◽  
Case Report ◽  
Severe Neutropenia ◽  
Peripheral Blood Flow ◽  
Entire Body ◽  
Tissue Necrosis ◽  
Cutaneous Lesions ◽  
Cocaine Use ◽  
Hands And Feet ◽  
Parasitic Worms

Cocaine is often “cut” with various additives to increase the profitability of the drug. One of the most common additives on today’s market is levamisole, an anthelmintic medication used to destroy and expel parasitic worms in animals. The use of levamisole-contaminated cocaine can result in agranulocytosis and vasculitis (inflammation and constriction of small blood vessels). The resulting clotting and decrease in peripheral blood flow lead to cutaneous lesions, particularly on the ears, face, hands, and feet, and in severe cases can cause generalized tissue necrosis throughout the entire body. Treatment is generally supportive, and symptoms typically abate with complete cessation of cocaine use. However, symptoms may recur with subsequent cocaine use and, as this case illustrates, severe neutropenia and extensive vasculitis may lead to overwhelming sepsis and death.

Poster 176: Enoxaparin Induced Tissue Necrosis: A Case Report

PM&R ◽  
2017 ◽  
Vol 9 ◽  
pp. S188-S188 ◽  
Author(s):  
Molly E. Schill ◽  
Clinton E. Faulk
Keyword(s):  
Case Report ◽  
Tissue Necrosis
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