scholarly journals Warfarin-Induced Tissue Necrosis (WITN): Case Report and Literature Review A Proposed Name Change

2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Simman R ◽  
Gould N ◽  
Jackson SE
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Tissue Necrosis ◽  
Name Change

scholarly journals Combination therapy with bosentan and sildenafil for refractory digital ulcers and Raynaud’s phenomenon in a 30-year-old woman with systemic sclerosis: Case report and literature review

2019 ◽  
Vol 5 (2) ◽  
pp. 159-164 ◽  
Author(s):  
Jan-Gerd Rademacher ◽  
Chris Wincup ◽  
Björn Tampe ◽  
Peter Korsten
Keyword(s):  
Case Report ◽  
Systemic Sclerosis ◽  
Literature Review ◽  
Combination Therapy ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Digital Ulcers ◽  
Channel Blockers ◽  
Tissue Necrosis ◽  
Diffuse Systemic Sclerosis

Background: Systemic sclerosis is a rare autoimmune disease characterized by skin and organ fibrosis, and vasculopathy. Raynaud’s phenomenon is almost universally present in systemic sclerosis and can be the most debilitating symptom. Raynaud’s phenomenon may lead to the development of digital ulcers, potentially complicated by infection, tissue necrosis, and auto-amputation. Recommended treatments have variable efficacy. Methods: We report the case of a 30-year-old woman with diffuse systemic sclerosis suffering from severe Raynaud’s phenomenon and digital ulcers with digital tissue necrosis who was treated with combination therapy of an endothelin receptor antagonist and phosphodiesterase 5 inhibitor. In addition, we reviewed the literature on the topic. Results: Previous therapy with calcium-channel blockers, intravenous iloprost, and bosentan had all failed to control symptoms. We added sildenafil in combination with bosentan and observed a rapid and sustained treatment effect. Raynaud’s phenomenon severity, number of attacks, and attack duration decreased within 2 weeks of initiating treatment. Furthermore, this resulted in the healing of established digital ulcers. Conclusion: Our case report suggests that combination therapy may be a feasible treatment for the most severely affected and refractory patients. In our literature review, we found one retrospective study and three additional cases with similarly encouraging results.

Brown recluse spider bite. A literature review and case report

1989 ◽  
Vol 79 (3) ◽  
pp. 142-146 ◽  
Author(s):  
M Gutowicz ◽  
RA Fritz ◽  
AL Sonoga
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Early Treatment ◽  
Clinical Presentation ◽  
Review Of The Literature ◽  
Tissue Necrosis ◽  
Future Studies ◽  
Treatment Regimens ◽  
Spider Bite ◽  
Treatment Prognosis

A review of the literature on brown recluse spider bite is presented, including clinical presentation and treatment. Emphasis is placed on the treatment of local tissue necrosis. A case report of a severe necrotic ulcer secondary to a spider bit is presented. Tissue necrosis following a brown recluse spider bit can be debilitating, and healing may be prolonged for many months. Even with early treatment, prognosis often is poor. Future studies might help establish better treatment regimens.

scholarly journals Myonecrosis in a Sickle Cell-Diseased Patient: A Case Report and Literature Review

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Ali Wasel Almomen ◽  
Yaser Mansour Tawfeeq ◽  
Ahmed Khalid Almuhaisin ◽  
Abdulraheem Ayman Altalib
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Sickle Cell ◽  
Muscle Tissue ◽  
Physical Disabilities ◽  
Supportive Therapy ◽  
Foot Pain ◽  
Tissue Necrosis ◽  
Characteristic Image

Myonecrosis is a condition that results in muscle tissue necrosis, and it is rarely seen in sickle cell patients and often missed because more common manifestations of sickle cell can overlap like vaso-occlusive crises (VOC), which results in pain in the extremities or spine; also osteomyelitis is commonly seen in sickle cell patients. In this article, we present a case of myonecrosis in a sickle cell-diseased patient who presented with left acute atraumatic left foot pain and MRI with contrast showing characteristic image of muscle infarction supportive therapy initiated, and 2-year follow-up did not reveal any physical disabilities; further study and follow-up are needed to know the nature of the disease and avoid improper management of those patients.

Valproate-induced hyperammonemia: A case report and literature review

2009 ◽  
Author(s):  
C. L. Khoo ◽  
L. Regina ◽  
S. R. K. Naik ◽  
S. Kang
Keyword(s):  
Case Report ◽  
Literature Review

Pre- and Peripartal Management of a Woman with McArdle Disease: A Case Report and Literature Review

2017 ◽  
Author(s):  
T Stopp ◽  
M Feichtinger ◽  
W Eppel ◽  
T Stulnig ◽  
P Husslein ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Mcardle Disease
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