scholarly journals A NOVEL METHOD FOR TREATING THE REFRACTORY AND SEVERE BENIGN CENTRAL AIRWAY STENOSIS WITH OSCILLATING POSITIVE EXPIRATORY PRESSURE: TWO CASES REPORT

Respirology ◽  
2018 ◽  
Vol 23 ◽  
pp. 100-100
2020 ◽  
Vol 56 (11) ◽  
pp. 695-696
Author(s):  
Fernando Guedes ◽  
Ana Colette Maurício ◽  
António Bugalho

Author(s):  
Swati a. Bhatawadekar ◽  
Anne E. Dixon ◽  
Ubong Peters ◽  
Nirav Daphtary ◽  
Kevin Hodgdon ◽  
...  

Late-onset non-allergic (LONA) asthma in obesity is characterized by increased peripheral airway closure secondary to abnormally collapsible airways. We hypothesized that positive expiratory pressure (PEP) would mitigate the tendency to airway closure during bronchoconstriction, potentially serving as rescue therapy for LONA asthma of obesity. The PC20 dose of methacholine was determined in 18 obese participants with LONA asthma. At each of 4 subsequent visits, we used oscillometry to measure input respiratory impedance (Zrs) over 8 minutes; participants received their PC20 concentration of methacholine aerosol during the first 4.5 minutes. PEP combinations of either 0 or 10 cmH2O either during and/or after the methacholine delivery were applied, randomized between visits. Parameters characterizing respiratory system mechanics were extracted from the Zrs spectra. In 18 LONA asthma patients (14 females, BMI: 39.6±3.4 kg/m2), 10 cmH2O PEP during methacholine reduced elevations in the central airway resistance, peripheral airway resistance and elastance, and breathing frequency was also reduced. During the 3.5 min following methacholine delivery, PEP of 10 cmH2O reduced Ax and peripheral elastance compared to no PEP. PEP mitigates the onset of airway narrowing brought on by methacholine challenge, and airway closure once it is established. PEP thus might serve as a non-pharmacologic therapy to manage acute airway narrowing for obese LONA asthma.


2005 ◽  
Vol 41 (6) ◽  
pp. 322-327 ◽  
Author(s):  
A. Cosano Povedano ◽  
L. Muñoz Cabrera ◽  
F.J. Cosano Povedano ◽  
J. Rubio Sánchez ◽  
N. Pascual Martínez ◽  
...  

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Akira Iyoda ◽  
Yoko Azuma ◽  
Atsushi Sano ◽  
Takashi Sakai ◽  
Satoshi Koezuka ◽  
...  

2020 ◽  
Vol 9 (1) ◽  
pp. 165-174 ◽  
Author(s):  
Li-Ping Cheng ◽  
Ye Gu ◽  
Xu-Wei Gui ◽  
Yong Fang ◽  
Hao Wang ◽  
...  

2013 ◽  
Vol 7 (5) ◽  
pp. 255-263 ◽  
Author(s):  
Daniela Gompelmann ◽  
Ralf Eberhardt ◽  
Maren Schuhmann ◽  
Claus P. Heussel ◽  
Felix J.F. Herth

2012 ◽  
Vol 1 (1) ◽  
pp. 46-53 ◽  
Author(s):  
Hervé Dutau ◽  
Fabien Maldonado ◽  
Sophie Laroumagne ◽  
Philippe Astoul

Respiration ◽  
2019 ◽  
Vol 97 (5) ◽  
pp. 484-494
Author(s):  
Faguang Jin ◽  
Qiang Li ◽  
Shiyue Li ◽  
Hongwu Wang ◽  
Chong Bai ◽  
...  

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