Maternal Overweight and Obesity and Genital Anomalies in Male Offspring: A Population-Based Swedish Cohort Study

2017 ◽  
Vol 31 (4) ◽  
pp. 317-327 ◽  
Author(s):  
Linn Håkonsen Arendt ◽  
Cecilia Høst Ramlau-Hansen ◽  
Morten Søndergaard Lindhard ◽  
Tine Brink Henriksen ◽  
Jørn Olsen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Population Based ◽  
Overweight And Obesity ◽  
Male Offspring ◽  
Maternal Overweight ◽  
Swedish Cohort

scholarly journals Maternal overweight and obesity in early pregnancy and risk of infant mortality: a population based cohort study in Sweden

BMJ ◽  
2014 ◽  
Vol 349 (dec02 6) ◽  
pp. g6572-g6572 ◽  
Author(s):  
S. Johansson ◽  
E. Villamor ◽  
M. Altman ◽  
A.-K. E. Bonamy ◽  
F. Granath ◽  
...  
Keyword(s):  
Cohort Study ◽  
Infant Mortality ◽  
Early Pregnancy ◽  
Population Based ◽  
Overweight And Obesity ◽  
Maternal Overweight

Population-based trends and correlates of maternal overweight and obesity, Utah 1991-2001

2005 ◽  
Vol 192 (3) ◽  
pp. 832-839 ◽  
Author(s):  
D. Yvette LaCoursiere ◽  
Lois Bloebaum ◽  
Jeffrey D. Duncan ◽  
Michael W. Varner
Keyword(s):  
Population Based ◽  
Overweight And Obesity ◽  
Maternal Overweight

scholarly journals Elective and nonelective cesarean section and obesity among young adult male offspring: A Swedish population–based cohort study

PLoS Medicine ◽  
2019 ◽  
Vol 16 (12) ◽  
pp. e1002996 ◽  
Author(s):  
Viktor H. Ahlqvist ◽  
Margareta Persson ◽  
Cecilia Magnusson ◽  
Daniel Berglind
Keyword(s):  
Cohort Study ◽  
Young Adult ◽  
Cesarean Section ◽  
Adult Male ◽  
Population Based ◽  
Male Offspring ◽  
Swedish Population ◽  
Young Adult Male

scholarly journals Is maternal weight gain between pregnancies associated with risk of large-for-gestational age birth? Analysis of a UK population-based cohort

BMJ Open ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. e026220 ◽  
Author(s):  
Nida Ziauddeen ◽  
Sam Wilding ◽  
Paul J Roderick ◽  
Nicholas S Macklon ◽  
Nisreen A Alwan
Keyword(s):  
Weight Gain ◽  
Gestational Age ◽  
Population Based ◽  
Overweight And Obesity ◽  
Large For Gestational Age ◽  
Adjusted Relative Risk ◽  
Maternal Weight ◽  
Overweight Women ◽  
Increased Risk ◽  
Maternal Overweight

ObjectiveMaternal overweight and obesity during pregnancy increases the risk of large-for-gestational age (LGA) birth and childhood obesity. We aimed to investigate the association between maternal weight change between subsequent pregnancies and risk of having a LGA birth.DesignPopulation-based cohort.SettingRoutinely collected antenatal healthcare data between January 2003 and September 2017 at University Hospital Southampton, England.ParticipantsHealth records of women with their first two consecutive singleton live-birth pregnancies were analysed (n=15 940).Primary outcome measureRisk of LGA, recurrent LGA and new LGA births in the second pregnancy.ResultsOf the 15 940 women, 16.0% lost and 47.7% gained weight (≥1 kg/m2) between pregnancies. A lower proportion of babies born to women who lost ≥1 kg/m2(12.4%) and remained weight stable between −1 and 1 kg/m2(11.9%) between pregnancies were LGA compared with 13.5% and 15.9% in women who gained 1–3 and ≥3 kg/m2, respectively. The highest proportion was in obese women who gained ≥3 kg/m2(21.2%). Overweight women had a reduced risk of recurrent LGA in the second pregnancy if they lost ≥1 kg/m2(adjusted relative risk (aRR) 0.69, 95% CI 0.48 to 0.97) whereas overweight women who gained ≥3 kg/m2were at increased risk of new LGA after having a non-LGA birth in their first pregnancy (aRR 1.35, 95% CI 1.05 to 1.75). Normal-weight women who gained weight were also at increased risk of new LGA in the second pregnancy (aRR 1.26, 95% CI 1.06 to 1.50 with gain of 1–3 kg/m2and aRR 1.34, 95% CI 1.09 to 1.65 with gain of ≥3 kg/m2).ConclusionsLosing weight after an LGA birth was associated with a reduced LGA risk in the next pregnancy in overweight women, while interpregnancy weight gain was associated with an increased new LGA risk. Preventing weight gain between pregnancies is an important measure to achieve better maternal and offspring outcomes.

Cerebrovascular and ischemic heart disease in young adults born preterm: a population-based Swedish cohort study

2014 ◽  
Vol 29 (4) ◽  
pp. 253-260 ◽  
Author(s):  
Peter Ueda ◽  
Sven Cnattingius ◽  
Olof Stephansson ◽  
Erik Ingelsson ◽  
Jonas F. Ludvigsson ◽  
...  
Keyword(s):  
Young Adults ◽  
Cohort Study ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Population Based ◽  
Ischemic Heart ◽  
Swedish Cohort

scholarly journals Maternal Obesity and Risk of Early-onset Neonatal Bacterial Sepsis: Nationwide Cohort and Sibling-controlled Studies

2020 ◽  
Author(s):  
Eduardo Villamor ◽  
Mikael Norman ◽  
Stefan Johansson ◽  
Sven Cnattingius
Keyword(s):  
Early Onset ◽  
Maternal Obesity ◽  
Group B Streptococcus ◽  
Population Based ◽  
Normal Weight ◽  
Overweight And Obesity ◽  
Bacterial Sepsis ◽  
Term Infants ◽  
Cesarean Section Delivery ◽  
Maternal Overweight

Abstract Background Maternal overweight and obesity are related to risks of pregnancy and delivery complications that, in turn, are associated with newborn infections. We examined the associations between early pregnancy body mass index (BMI; kg/m2) and risk of early-onset neonatal bacterial sepsis (EOS). Methods We conducted a nationwide population-based retrospective cohort study of 1 971 346 live singleton infants born in Sweden between 1997 and 2016. Outcome was a culture-confirmed EOS diagnosis. We estimated hazard ratios (HR) of EOS according to BMI using proportional hazard models, and identified potential mediators. Among term infants, we conducted sibling-controlled analyses. Results EOS risk per 1000 live births was 1.48; 0.76 in term and 15.52 in preterm infants. Compared with infants of normal-weight mothers (BMI, 18.5–24.9), the adjusted HR (95% confidence interval [CI]) of EOS for BMI categories <18.5, 25.0–29.9, 30.0–34.9, 35.0–39.9, and ≥40.0 were, respectively, 1.07 (.83–1.40), 1.19 (1.08–1.32), 1.70 (1.49–1.94), 2.11 (1.73–2.58), and 2.50 (1.86–3.38). Maternal overweight and obesity increased the risk of EOS by group B Streptococcus, Staphylococcus aureus, and Escherichia coli. Half of the association was mediated through preeclampsia, cesarean section delivery, and preterm delivery. A dose-response association was consistently apparent in term infants only. In sibling-controlled analyses, every kilogram per meter squared interpregnancy BMI change was associated with a mean 8.3% increase in EOS risk (95% CI, 1.7%–15.3%; P = .01). Conclusions Risk of EOS increases with maternal overweight and obesity severity, particularly in term infants.

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