The first case of gastric leiomyosarcoma developed through malignant transformation of leiomyoma

2021 ◽  
Author(s):  
Amane Yamamoto ◽  
Yoko Tateishi ◽  
Susumu Aikou ◽  
Yasuyuki Seto ◽  
Tetsuo Ushiku
Keyword(s):  
Malignant Transformation ◽  
First Case ◽  
Gastric Leiomyosarcoma

scholarly journals Response to 5-Fluorouracil-Based Chemotherapy in a Patient with Metastatic Colonic-Type Adenocarcinoma Arising in a Primary Mediastinal Teratoma

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
Arunee Dechaphunkul ◽  
Gilbert Bigras ◽  
Michael Sawyer
Keyword(s):  
Germ Cell ◽  
Malignant Transformation ◽  
Germ Cell Tumor ◽  
Primitive Neuroectodermal Tumor ◽  
Chemotherapy Regimen ◽  
Cell Tumor ◽  
Neuroectodermal Tumor ◽  
Mediastinal Teratoma ◽  
First Case ◽  
Localized Disease

Germ cell tumor with somatic malignant transformation is an uncommon phenomenon occurring about 7% of all mediastinal teratomas. Among all transformed component, sarcoma appears to be the most frequent histology, followed by primitive neuroectodermal tumor (PNET) and adenocarcinoma. To our knowledge, there were 3 cases of colonic-type adenocarcinoma arising in a primary teratoma have been reported to date. However, none of them received chemotherapy directed to transformed histology given localized disease at presentation. We, therefore, report here the first case of patient who achieved good response from chemotherapy directed to transformed histology, which confirms the importance of chemotherapy regimen used.

Dynamic changes in magnetic resonance imaging appearance of dysembryoplastic neuroepithelial tumor with or without malignant transformation

2013 ◽  
Vol 11 (5) ◽  
pp. 518-525 ◽  
Author(s):  
Yui Mano ◽  
Toshihiro Kumabe ◽  
Ichiyo Shibahara ◽  
Ryuta Saito ◽  
Yukihiko Sonoda ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Gross Total Resection ◽  
Subtotal Resection ◽  
Dysembryoplastic Neuroepithelial Tumor ◽  
Total Resection ◽  
Who Grade ◽  
Adjuvant Radiochemotherapy ◽  
First Case ◽  
Complex Forms

Dysembryoplastic neuroepithelial tumors (DNETs) have conventionally been regarded as benign and stable tumors and considered curable with surgery without adjunctive therapy. Recently, recurrent DNETs with or without malignant transformation have been described. The authors report 2 unusual cases of DNET: 1) an enlarging lesion that developed an enhancing component over the natural course of 4 years, and 2) a recurrent DNET that developed an enhancing component 10–11 years after gross-total resection. The patient in the first case was treated with subtotal resection and adjuvant radiochemotherapy; histological examination of the tumor led to the diagnosis of DNET, WHO Grade I, for the nonenhancing component and anaplastic oligodendroglioma, WHO Grade III, for the enhancing component. The patient in the second case was treated with repeat gross-total resection; the original tumor had been histologically diagnosed as DNET, and the nonenhancing and enhancing components of the recurrent tumor were diagnosed as simple and complex forms of DNET, respectively. These and previous reports suggest an aggressive subtype of DNETs. If follow-up MRI reveals progressive behavior, resection should be performed without delay. Additional radiochemotherapy is needed if the histological diagnosis demonstrates malignant transformation.

scholarly journals Squamous cell carcinoma arising in ovarian mature cystic teratoma: report of three cases

1970 ◽  
Vol 2 (3) ◽  
pp. 248-250 ◽  
Author(s):  
R Bashyal ◽  
MC Lee
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Postmenopausal Women ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Malignant Tumors ◽  
Cystic Teratoma ◽  
Squamous Cell Carcinomas ◽  
Mature Cystic Teratoma ◽  
First Case

Malignant transformation of mature cystic teratoma of the ovary is rare. A wide variety of malignant tumors may arise within benign mature cystic teratoma. The most common form of malignant transformation of a mature cystic teratoma is squamous cell carcinoma. We report a series of three cases that developed squamous cell carcinoma in a benign ovarian cystic teratoma. Two of the carcinomas occurred in postmenopausal women: 51-year-old (case # 2) and 60 year-old (case # 3). The first case occurred in a 33-year-old woman. Histologically, all three cases were moderately differentiated squamous cell carcinomas and were confined to the ovaries. The aim of this study was to review our experience with this disease and to review the literature. DOI: http://dx.doi.org/10.3126/jpn.v2i3.6032 JPN 2012; 2(3): 248-250

Malignant transformation of intracranial mature teratoma to yolk sac tumor after late relapse

2007 ◽  
Vol 106 (6) ◽  
pp. 1067-1069 ◽  
Author(s):  
Satoshi Utsuki ◽  
Hidehiro Oka ◽  
Takao Sagiuchi ◽  
Satoru Shimizu ◽  
Sachio Suzuki ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Third Ventricle ◽  
Mature Teratoma ◽  
Germ Cell Tumors ◽  
Yolk Sac ◽  
Yolk Sac Tumor ◽  
Late Relapse ◽  
Computed Tomography Images ◽  
First Case ◽  
History Of

✓ The recurrence of intracranial mature teratomas as germ cell tumors of different histological types is rarely reported. The authors describe the first case of the malignant transformation of an intracranial mature teratoma into a yolk sac tumor in a 16-year-old boy who presented with a 1-month history of anorexia and somnolence. Seven years prior to this presentation, the boy had undergone surgery for extirpation of a mature pineal teratoma. Computed tomography images obtained at his second presentation revealed a homogeneously enhanced mass within the third ventricle. The tumor was resected and the results of a histological examination were consistent with a yolk sac tumor. After resection, the patient underwent radiation therapy followed by chemotherapy with cisplatin and etoposide but died of tumor progression 15 months after his second hospitalization.

Transformation from Sinonasal Seromucinous Hamartoma to Adenocarcinoma: A Case Report

ORL ◽  
2021 ◽  
pp. 1-3
Author(s):  
David A. Rengifo ◽  
Varun V. Varadarajan ◽  
Jinping Lai ◽  
Jeb M. Justice
Keyword(s):  
Malignant Transformation ◽  
Middle Turbinate ◽  
Sinus Surgery ◽  
Low Grade ◽  
Complete Excision ◽  
Nasal Mass ◽  
Respiratory Epithelial Adenomatoid Hamartoma ◽  
Seromucinous Hamartoma ◽  
First Case ◽  
Risk Of Malignancy

<b><i>Objectives:</i></b> Sinonasal hamartomas are benign neoplasms composed of disorganized mature tissue elements. Epithelial variants include respiratory epithelial adenomatoid hamartoma (REAH) and seromucinous hamartoma (SMH). Malignant transformation of REAH is rarely reported; however, the malignant transformation of SMH to adenocarcinoma has not been described. We report the first case of a transformation from SMH to adenocarcinoma. <b><i>Methods:</i></b> The medical records of a patient presenting with sinonasal SMH with malignant transformation to adenocarcinoma were reviewed. The NCBI database was queried for the literature regarding SMH and malignant transformation of sinonasal hamartomas. <b><i>Results:</i></b> A 39-year-old man presented with a left nasal mass, nasal obstruction, and epistaxis. Computed tomography and magnetic resonance imaging demonstrated a nonaggressive and heterogeneous left nasal mass with involvement of the middle turbinate and posterior ethmoid sinuses. He underwent endoscopic sinus surgery with complete excision of the mass. Pathology revealed SMH with focal areas of transition to low-grade adenocarcinoma characterized by stromal invasion but no bony, perineural, or lymphovascular invasion. Adjuvant treatment was not recommended. Literature review revealed no reported cases of malignant transformation of SMH. <b><i>Conclusion:</i></b> We report the first case of malignant transformation of SMH. Patients with SMH must be counseled that there is an extremely rare and potentially unrecognized risk of malignancy that may influence treatment and postoperative monitoring.

Liver Transplantation for Hepatic Adenomatosis: The First Case Report in Thailand and Literature Review

2021 ◽  
Vol 104 (2) ◽  
pp. 320-325
Keyword(s):  
Liver Transplantation ◽  
Malignant Transformation ◽  
Liver Tumors ◽  
Rescue Therapy ◽  
Transarterial Embolization ◽  
Abdominal Mass ◽  
Normal Liver ◽  
First Case ◽  
Explanted Liver ◽  
Hepatic Adenomatosis

Hepatic adenomas are benign solid liver tumors commonly found in young females and usually asymptomatic. Hepatic adenomatosis is characterized by more than 10 adenomas in an otherwise normal liver. Bleeding and malignant transformation uncommonly occur especially in tumor larger than 5 cm and in male patients. The authors reported a case of a young female with large multiple hepatic adenomas from hepatic adenomatosis that presented with abdominal pain, large abdominal mass, weight lost, and abnormal liver function tests. She failed transarterial embolization. Surgical resection was not offered due to extent of the hepatic adenomas. She received orthotopic liver transplantation as rescue therapy. Her explanted liver showed multiple foci of hepatocellular carcinoma (HCC). Her post-operative was uneventful. The authors reported a case of liver transplantation for the treatment of unresectable hepatic adenomatosis. Keywords: Hepatic adenomatosis, Malignant transformation, Liver transplantation

scholarly journals First report of pulmonary sclerosing pneomucytoma with malignant transformation in both cuboidal surface cells and stromal round cells: a case report

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Xiao Teng ◽  
Xiaodong Teng
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Malignant Transformation ◽  
Metastatic Lymph Node ◽  
Lower Lobe ◽  
Proliferation Index ◽  
Pathological Examination ◽  
Node Metastasis ◽  
Mesenchymal To Epithelial Transition ◽  
First Case

Abstract Background Pulmonary sclerosing pneumocytoma (PSP) is a rare benign tumor. Although lymph node metastasis has been reported, it is still considered benign. No malignant transformation has been reported. This is the first case of malignant transformation of both cuboidal surface cells and stromal round cells. Case presentation A 64-year-old male had been complaining of intermittent hemoptysis several times per day for eight months. Chest computed tomography scan showed parenchymal infiltration with cystic lesion in the right lower lobe accompanied by enlarged right hilar lymph nodes. Lobectomy and systemic lymph node dissection was performed. On grossly pathological examination, the lesion was 50 mm from the bronchial stump. It was a mixture of both cystic and solid components and 30 mm * 20 mm in size with unclear border. Microscopically, the cuboidal surface cells transformed to adenocarcinoma. The stromal round cells also had a malignant transformation. The Ki-67 proliferation index in malignant cuboidal surface cells and stromal round cells were 70 and 55%, respectively. Furthermore, E-cadherin was negative in primary tumor but positive in metastatic lymph node, which suggested that the mesenchymal to epithelial transition may play an important role in lymph node metastasis. Conclusions To our knowledge, we present the first case of malignant transformation of both cuboidal surface cells and stromal round cells in PSP. The process of mesenchymal to epithelial transition may play an important role in lymph node metastasis.

scholarly journals Recurrent respiratory papillomatosis with malignant transformation

2021 ◽  
Vol 67 (2) ◽  
pp. 282-286
Author(s):  
Valentina Molodczova ◽  
Andrey Il`in ◽  
Nikita Kazakov ◽  
Andrey Litvinov ◽  
Andrey Akopov
Keyword(s):  
Lung Cancer ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Lower Respiratory Tract ◽  
Recurrent Respiratory Papillomatosis ◽  
Careful Monitoring ◽  
Hpv Typing ◽  
First Case ◽  
History Of ◽  
Case Development

Recurrent respiratory papillomatosis (RRP) is a rare disease with an unpredictable course. The etiology is associated with the human papillomavirus (HPV). Malignant transformation of papillomas is extremely rare. Two clinical cases of RRP malignization are presented. In the first case, 22-year-old women with a long history of RRP and the lower respiratory tract lesions, squamous cell lung cancer developed. Second case - development of squamous cell carcinoma from the tracheal papilloma in a 35-year-old patient. Aggressive local endobronchial treatment was carried out; however, the prognosis remains pessimistic due to the absence of etiopathogenetic therapy for RRP. Careful monitoring including HPV typing is mandatory, since infection with aggressive HPV strains leads to rapid proliferation of papillomas and malignant transformation.

scholarly journals Comprehensive molecular imaging of malignant transformation of giant cell tumour of bone reveals diverse disease biology

2019 ◽  
Vol 12 (4) ◽  
pp. e218839 ◽  
Author(s):  
Kalevi Kairemo ◽  
Wei-Lien Wang ◽  
Vivek Subbiah
Keyword(s):  
Molecular Imaging ◽  
Bone Formation ◽  
Lymph Nodes ◽  
Giant Cell ◽  
Malignant Transformation ◽  
Soft Tissues ◽  
Giant Cell Tumour ◽  
Cell Tumour ◽  
X Rays ◽  
First Case

Malignant transformation of giant cell tumour of the bone is extremely rare. In addition, bone transformation in giant cell tumour may occur in different phases. With conventional X-rays, CT scans or MRIs, it may be challenging to distinguish among different phases of bone transformation, normal bone, soft tissue disease and bone disease (benign vs malignant lesions) and changes in multiple organs such as lung, liver and lymph nodes unless every lesion is biopsied, which is not practical. Molecular imaging with different isotopes (Tc-99m phosphonate, 2-deoxy-2-(18F)fluoro-d-glucose and sodium fluoride-18) may help to better characterise the disease. We hypothesised that molecular imaging could offer qualitative and quantitative characterisation of all stages of bone formation, destruction, reactivity or neoplasia in a patient with giant cell tumour of the bone, and we present the first case of molecular imaging where bone formation was seen in multiple soft tissues, such as lungs, muscles, lymph nodes and liver.

Retrorectal Cystic Hamartoma (Tail Gut Cyst): An Institutional Experience

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S55-S55
Author(s):  
Hatem Kaseb ◽  
Xuchen Zhang
Keyword(s):  
Malignant Transformation ◽  
Resection Margin ◽  
Surgical Excision ◽  
Pathology Report ◽  
Tailgut Cyst ◽  
First Case ◽  
Retrorectal Cystic Hamartoma ◽  
Surgical Data ◽  
Tail Gut Cyst ◽  
Cystic Hamartoma

Abstract Objectives Tailgut cyst (TGC) is a rare congenital benign cystic lesion arising from a remnant of the embryonic postnatal hindgut. TGCs are typically multinodular, uncapsulated, but usually well circumscribed. TGCs are generally rare in adults and the majority of the lesions are benign. Malignant transformation is rare and malignancies reported include adenocarcinomas and neuroendocrine tumors. Methods A retrospective database search was conducted and coded as “tailgut cyst or retrorectal cystic hamartoma” to identify cases of possible TGC between January 2005 and January 2019. The search utilized the pathology files of Yale-New Haven Hospital using CoPath laboratory information system. Clinical and surgical data were gathered from the surgical pathology report and surgical operative note when available. Results A total of 13 cases (10 women) were identified with a median age of 51 years. All the specimens were obtained by surgical excision. Most of the cases were excised from the presacreal area (11 cases), and two cases were excised from the retrorectal area. The two cases resected from the retrorectal area had a malignant component. The first case was a 33-year-old female who had a 1.5-cm tailgut cyst that showed a multifocal neuroendocrine tumor (carcinoid); the resection margin was also positive. The second case was a 59-year-old female who had a tailgut cyst that showed mucinous adenocarcinoma; the resection margin was also positive. Conclusion Diagnosis of tailgut is sometimes challenging. Possible differential diagnoses in this location include teratoma, dermoid cyst, anterior sacral meningocele, and presacral abscess. Imaging is an important component of the initial workup. Surgical resection is the treatment of choice when the cyst grows in size and if a solid component is present. Exclusion of other benign entities and malignant transformation/component on histological examination is crucial.

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