scholarly journals Response to 5-Fluorouracil-Based Chemotherapy in a Patient with Metastatic Colonic-Type Adenocarcinoma Arising in a Primary Mediastinal Teratoma

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
Arunee Dechaphunkul ◽  
Gilbert Bigras ◽  
Michael Sawyer
Keyword(s):  
Germ Cell ◽  
Malignant Transformation ◽  
Germ Cell Tumor ◽  
Primitive Neuroectodermal Tumor ◽  
Chemotherapy Regimen ◽  
Cell Tumor ◽  
Neuroectodermal Tumor ◽  
Mediastinal Teratoma ◽  
First Case ◽  
Localized Disease

Germ cell tumor with somatic malignant transformation is an uncommon phenomenon occurring about 7% of all mediastinal teratomas. Among all transformed component, sarcoma appears to be the most frequent histology, followed by primitive neuroectodermal tumor (PNET) and adenocarcinoma. To our knowledge, there were 3 cases of colonic-type adenocarcinoma arising in a primary teratoma have been reported to date. However, none of them received chemotherapy directed to transformed histology given localized disease at presentation. We, therefore, report here the first case of patient who achieved good response from chemotherapy directed to transformed histology, which confirms the importance of chemotherapy regimen used.

Primitive Neuroectodermal Tumor (PNET) as Somatic-Type Malignancy Arising from an Extragonadal Germ-Cell Tumor: Clinical, Pathological and Molecular Features of a Case

2013 ◽  
Vol 99 (1) ◽  
pp. e24-e27 ◽  
Author(s):  
Amit Garg ◽  
Ayoub Nahal ◽  
Robert Turcotte ◽  
Roger Tabah ◽  
Thierry Alcindor
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Primitive Neuroectodermal Tumor ◽  
Cell Tumor ◽  
Neuroectodermal Tumor ◽  
Chromosome 22 ◽  
Round Cell ◽  
Molecular Features ◽  
Nonseminomatous Germ Cell Tumor ◽  
Axillary Mass

We report a rare case of a 34-year-old man with a right axillary mass. Ten years previously, he had been diagnosed with a right scapular nonseminomatous germ-cell tumor consisting of teratoma, completely resected without any further treatment. Presently he was found to have a metastatic malignant small round cell tumor consistent with a secondary somatic malignancy arising in the background of nonseminomatous germ-cell tumor, teratoma, yolk sac tumor, and primitive neuroectodermal tumor with distinct chromosome 22 translocation. Although the patient initially responded well to chemotherapy with etoposide, cisplatin, ifosfamide and mesna, he relapsed shortly after.

Malignant Transformation and Treatment of Cystic Mixed Germ Cell Tumor

2016 ◽  
Vol 2 (1) ◽  
pp. 25-30
Author(s):  
Yapeng Zhao ◽  
Hongyu Duan ◽  
Qinghui Zhang ◽  
Bingxin Shi ◽  
Hui Liang ◽  
...  
Keyword(s):  
Germ Cell ◽  
Malignant Transformation ◽  
Germ Cell Tumor ◽  
Cell Tumor ◽  
Mixed Germ Cell Tumor

Cystic Trophoblastic Tumor in a Primary Central Nervous System Post-Chemotherapy Germ Cell Tumor: The First Case Report

2020 ◽  
Vol 28 (8) ◽  
pp. 925-928
Author(s):  
Ramya Gadde ◽  
Kanika Arora ◽  
Michelle Madden Felicella ◽  
Sohrab Arora ◽  
Liang Cheng ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Germ Cell Tumors ◽  
Testicular Tumor ◽  
Cell Tumor ◽  
Smooth Muscle Tissue ◽  
Trophoblastic Tumor ◽  
First Case

Cystic trophoblastic tumor (CTT) is an uncommon trophoblastic proliferation of germ cell tumor origin, mostly reported in post-chemotherapy metastases of testicular germ cell tumors and rarely primary untreated testicular tumors. To date, we are not aware of occurrence in a non-testicular tumor. A 12-year-old boy presented with limb swelling, increased appetite, weight gain, and precocious puberty. Evaluation revealed right frontal lobe mass and elevated α-fetoprotein and β-human chorionic gonadotrophin. After response to neoadjuvant chemotherapy, the tumor was resected. Microscopically, the resection contained predominantly smooth muscle tissue with scattered small foci of glandular teratoma and CTT. Immunohistochemistry (SALL4, glypican 3) revealed no residual yolk sac tumor. Fluorescence in situ hybridization revealed gain of chromosome 12p. The patient has been disease-free for 13 years. This report expands the spectrum of primary central nervous system germ cell tumors with the occurrence of CTT in this site.

scholarly journals A 23-Year-Old Female with a Mixed Germ Cell Tumor of the Pituitary Infundibulum: The Challenge of Differentiating Neoplasm from Lymphocytic Infundibuloneurohypophysitis—A Case Report and Literature Review

2014 ◽  
Vol 2014 ◽  
pp. 1-7
Author(s):  
Sann Yu Mon ◽  
Hussain Mahmud ◽  
Munira Abbasi ◽  
Geoff Murdoch ◽  
Juan C. Fernandez-Miranda ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Histopathological Examination ◽  
Cell Tumor ◽  
Mri Imaging ◽  
Mixed Germ Cell Tumor ◽  
First Case ◽  
Imaging Characteristics ◽  
Progression Of Disease ◽  
Broad Variety

The pathologic spectrum of diseases that infiltrate the pituitary infundibulum includes a broad variety of clinical entities. There are significant differences in the prevalence of these etiologies depending on the age of presentation. Lymphocytic infundibuloneurohypophysitis (LINH) predominates over other causes of infundibular disease in adults over age 21. Differentiating LINH from other causes of infundibular disease can be difficult because the various etiologies often have similar clinical presentations and radiologic imaging characteristics. We report the first case in an adult of a mixed germ cell tumor comprised of germinoma and embryonal cell carcinoma infiltrating the pituitary infundibulum. In our case, a 23-year-old female was initially misdiagnosed as having LINH. She presented with panhypopituitarism and diabetes insipidus, which is the most common initial presentation in both entities. The two diagnoses are difficult to distinguish based on MRI imaging, CSF findings, and histopathological examination. Our case demonstrates the need for close follow-up of patients with isolated lesions of the pituitary infundibulum and reinforces the need for biopsy of an infundibular lesion when progression of disease is demonstrated. In our case, biopsy with comprehensive immunohistochemical staining was the sole means of making a definitive diagnosis.

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