Covalent vaccination with Trypanosoma cruzi Tc24 induces catalytic antibody production

2018 ◽  
Vol 40 (11) ◽  
pp. e12585 ◽  
Author(s):  
Sarah M. Gunter ◽  
Leroy Versteeg ◽  
Kathryn M. Jones ◽  
Brian P. Keegan ◽  
Ulrich Strych ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Antibody Production ◽  
Catalytic Antibody

scholarly journals Evolution of anti-Trypanosoma cruzi antibody production in patients with chronic Chagas disease: Correlation between antibody titers and development of cardiac disease severity

2017 ◽  
Vol 11 (7) ◽  
pp. e0005796 ◽  
Author(s):  
Ingebourg Georg ◽  
Alejandro Marcel Hasslocher-Moreno ◽  
Sergio Salles Xavier ◽  
Marcelo Teixeira de Holanda ◽  
Eric Henrique Roma ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Disease Severity ◽  
Chagas Disease ◽  
Antibody Production ◽  
Cardiac Disease ◽  
Antibody Titers ◽  
Chronic Chagas Disease

scholarly journals Evaluation of Clinical and Immunopathological Features of Different Infective Doses ofTrypanosoma cruziin Dogs during the Acute Phase

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Israel A. Quijano-Hernández ◽  
Alejandro Castro-Barcena ◽  
Esteban Aparicio-Burgos ◽  
Marco A. Barbosa-Mireles ◽  
Julio V. Cruz-Chan ◽  
...  
Keyword(s):  
Latin America ◽  
Trypanosoma Cruzi ◽  
Acute Phase ◽  
Antibody Production ◽  
Cardiac Arrhythmias ◽  
Similar Pattern ◽  
Low Dose ◽  
Pathologic Lesions ◽  
Electrocardiographic Parameters ◽  
High Parasite

Infection withTrypanosoma cruziis a major risk in Latin America, and dogs are believed to be good models for evaluating Chagas disease. Here, we evaluated the clinical and immunopathological alterations developed by mongrel dogs experimentally infected with different infective doses (2,000, 20,000, and 200,000 metacyclic trypomastigotes of Sylvio X10/4 strain kg−1via intraperitoneal). Clinical and electrocardiographic parameters, as well as antibody production and pathologic lesions were evaluated. All three doses of this strain ofT. cruziinduced a similar pattern of infection characterized by cardiac arrhythmias and severe and diffuse myocarditis. Specific anti-T. cruziIgG indicated seroconversion by day 14 after infection, and IgG levels increased during the period of evaluation. Mortality was observed only in dogs infected with the medium or high parasite doses, but not in the group infected with a low dose of 2,000 parasites kg-1. Infection with a low dose of parasites provides an excellent nonlethal model to evaluate the immunopathology of the acute disease in dogs infected with the Sylvio X10/4 strain ofT. cruzi.

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