Trypanosoma cruzi: Antibody Production and T Cell Response Induced by Stage-Specific Surface Glycoproteins Purified from Metacyclic Trypomastigotes

1993 ◽  
Vol 77 (4) ◽  
pp. 405-413 ◽  
Author(s):  
N. Yoshida ◽  
J.E. Araya ◽  
J.F. Dasilveira ◽  
S. Giorgio
Keyword(s):  
T Cell ◽  
Trypanosoma Cruzi ◽  
Specific Surface ◽  
Antibody Production ◽  
Cell Response ◽  
T Cell Response ◽  
Metacyclic Trypomastigotes ◽  
Surface Glycoproteins

IL‐18R signaling is required for γδ T cell response and confers resistance to Trypanosoma cruzi infection

2020 ◽  
Vol 108 (4) ◽  
pp. 1239-1251
Author(s):  
Julia Barbalho da Mota ◽  
Juliana Echevarria‐Lima ◽  
Fernanda Kyle‐Cezar ◽  
Matheus Melo ◽  
Maria Bellio ◽  
...  
Keyword(s):  
T Cell ◽  
Trypanosoma Cruzi ◽  
Cell Response ◽  
T Cell Response ◽  
Γδ T Cell ◽  
Cruzi Infection

scholarly journals Oral Exposure to Trypanosoma cruzi Elicits a Systemic CD8+T Cell Response and Protection against Heterotopic Challenge

2011 ◽  
Vol 79 (8) ◽  
pp. 3397-3406 ◽  
Author(s):  
Matthew H. Collins ◽  
Julie M. Craft ◽  
Juan M. Bustamante ◽  
Rick L. Tarleton
Keyword(s):  
T Cell ◽  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Cell Response ◽  
Oral Route ◽  
T Cell Response ◽  
Oral Exposure ◽  
Oral Vaccination ◽  
Content Type ◽  
Route Of Infection

ABSTRACTTrypanosoma cruziinfects millions of people in Latin America and often leads to the development of Chagas disease.T. cruziinfection can be acquired at or near the bite site of the triatomine vector, butper osinfection is also a well-documented mode of transmission, as evidenced by recent microepidemics of acute Chagas disease attributed to the consumption of parasite-contaminated foods and liquids. It would also be convenient to deliver vaccines forT. cruziby the oral route, particularly live parasite vaccines intended for the immunization of reservoir hosts. For these reasons, we were interested in better understanding immunity toT. cruzifollowing oral infection or oral vaccination, knowing that the route of infection and site of antigen encounter can have substantial effects on the ensuing immune response. Here, we show that the route of infection does not alter the ability ofT. cruzito establish infection in muscle tissue nor does it impair the generation of a robust CD8+T cell response. Importantly, oral vaccination with attenuated parasites provides protection against wild-type (WT)T. cruzichallenge. These results strongly support the development of whole-organism-based vaccines targeting reservoir species as a means to alleviate the burden of Chagas disease in affected regions.

Suppression of autoreactive T-cell response to glycoprotein IIb/IIIa by blockade of CD40/CD154 interaction: implications for treatment of immune thrombocytopenic purpura

Blood ◽  
2003 ◽  
Vol 101 (2) ◽  
pp. 621-623 ◽  
Author(s):  
Masataka Kuwana ◽  
Yutaka Kawakami ◽  
Yasuo Ikeda
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Lines ◽  
Antibody Production ◽  
Immune Thrombocytopenic Purpura ◽  
Cell Response ◽  
T Cell Response ◽  
Thrombocytopenic Purpura ◽  
Autoreactive T Cell ◽  
T Cell Lines

The potential immunosuppressive effect of an anti-CD154 monoclonal antibody (mAb) on the pathogenic autoreactive T-cell response was evaluated using an in vitro culture system with glycoprotein IIb/IIIa (GPIIb/IIIa)–reactive T cells from patients with immune thrombocytopenic purpura (ITP). The anti-CD154 mAb did not inhibit T-cell proliferation, but suppressed anti-GPIIb/IIIa antibody production, in bulk peripheral blood mononuclear cell cultures stimulated with GPIIb/IIIa. Repeated antigenic stimulation of GPIIb/IIIa-reactive CD4+ T-cell lines in the presence of anti-CD154 mAb resulted in the loss of proliferative capacity and helper function for promoting anti-GPIIb/IIIa antibody production. These anergic T-cell lines showed a cytokine profile of low interferon γ and high interleukin 10 and suppressed anti-GPIIb/IIIa antibody production. Our results indicate that blockade of the CD40/CD154 interaction induces generation of autoantigen-specific anergic CD4+ T cells with regulatory function and could be a therapeutic option for suppressing pathogenic autoimmune responses in patients with ITP.

scholarly journals T cell responses to SARS-CoV-2 in healthy controls and primary immunodeficiency patients

2022 ◽  
Author(s):  
Arnold Awuah ◽  
Ava Zamani ◽  
Fariba Tahami ◽  
Mark Davis ◽  
Louis Grandjean ◽  
...  
Keyword(s):  
T Cell ◽  
Primary Immunodeficiency ◽  
Antibody Production ◽  
Cell Response ◽  
T Cell Responses ◽  
T Cell Response ◽  
Functional Assay ◽  
Healthy Controls ◽  
Cell Responses

Abstract Understanding the T cell response to SARS-CoV-2 is key in patients who lack antibody production. We demonstrate the applicability of a functional assay to measure the T cell response in a cohort of patients with immunodeficiency.

scholarly journals Mild Cytokine Elevation, Moderate CD4+ T Cell Response and Abundant Antibody Production in Children with COVID-19

2020 ◽  
Author(s):  
Ran Jia ◽  
Xiangshi Wang ◽  
Pengcheng Liu ◽  
Xiaozhen Liang ◽  
Yanling Ge ◽  
...  
Keyword(s):  
T Cell ◽  
Antibody Production ◽  
Cell Response ◽  
T Cell Response ◽  
Cd4 T Cell

scholarly journals Unconventional Pro-inflammatory CD4+ T Cell Response in B Cell-Deficient Mice Infected with Trypanosoma cruzi

2017 ◽  
Vol 8 ◽  
Author(s):  
Melisa Gorosito Serrán ◽  
Jimena Tosello Boari ◽  
Facundo Fiocca Vernengo ◽  
Cristian G. Beccaría ◽  
María C. Ramello ◽  
...  
Keyword(s):  
T Cell ◽  
Trypanosoma Cruzi ◽  
B Cell ◽  
Cell Response ◽  
T Cell Response ◽  
Cd4 T Cell ◽  
Deficient Mice

CD8+ T Cell Response to Trypanosoma cruzi Antigens during Chronic Chagas Disease

2019 ◽  
pp. 349-361
Author(s):  
Paola Lasso ◽  
Jose Mateus ◽  
John Mario González ◽  
Adriana Cuéllar ◽  
Concepción Puerta
Keyword(s):  
T Cell ◽  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Cell Response ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Chronic Chagas Disease

scholarly journals Distinct Kinetics of Effector CD8+ Cytotoxic T Cells after Infection with Trypanosoma cruzi in Naïve or Vaccinated Mice

2006 ◽  
Vol 74 (4) ◽  
pp. 2477-2481 ◽  
Author(s):  
Fanny Tzelepis ◽  
Bruna C. G. de Alencar ◽  
Marcus L. O. Penido ◽  
Ricardo T. Gazzinelli ◽  
Pedro M. Persechini ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Trypanosoma Cruzi ◽  
Cell Response ◽  
Cytotoxic T Cells ◽  
T Cell Responses ◽  
T Cell Response ◽  
Cell Responses ◽  
Microbial Infections ◽  
Kinetics Of

ABSTRACT The kinetics of effector CD8+-T-cell responses to specific Trypanosoma cruzi epitopes was investigated after challenge. Our results suggest that the delayed kinetics differs from that observed in other microbial infections and facilitates the establishment of the disease in naïve mice. In contrast, in vaccinated mice, the swift CD8+-T-cell response helps host survival after challenge.

Sign in / Sign up

Export Citation Format

Share Document