A dose-finding study for hemoporfin in photodynamic therapy for port-wine stain: A multicenter randomized double-blind phase IIb trial

2018 ◽  
Vol 34 (5) ◽  
pp. 314-321 ◽  
Author(s):  
Qiuju Wu ◽  
Ping Tu ◽  
Guoyu Zhou ◽  
Huilan Yang ◽  
Zhanchao Zhou ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Dose Finding ◽  
Port Wine Stain ◽  
Port Wine ◽  
Double Blind ◽  
Finding Study ◽  
Dose Finding Study

scholarly journals Double-blind, randomised, placebo-controlled, dose-finding study of oral ibandronate in patients with metastatic bone disease

1999 ◽  
Vol 10 (3) ◽  
pp. 311-316 ◽  
Author(s):  
R.E. Coleman ◽  
O.P. Purohit ◽  
C. Black ◽  
J.J. F. Vinholes ◽  
K. Schlosser ◽  
...  
Keyword(s):  
Bone Disease ◽  
Metastatic Bone Disease ◽  
Dose Finding ◽  
Double Blind ◽  
Finding Study ◽  
Dose Finding Study

The effect of several doses of oral tocainide HC1 on tinnitus: a dose-finding study

1984 ◽  
Vol 98 (S9) ◽  
pp. 257-258
Author(s):  
Jan H. Hulshof ◽  
Pieter Vermey
Keyword(s):  
Oral Administration ◽  
Controlled Trial ◽  
Dose Finding ◽  
Double Blind ◽  
Considerable Research ◽  
Finding Study ◽  
Dose Finding Study ◽  
Single Blind ◽  
Different Doses

From all methods of the treatment of tinnitus, medical, masking, surgery, electrical stimulation and psychological, we believe a reliable medical treatment would be preferable because it is easy to apply. An immense variety of drugs have been used for the treatment of tinnitus (Vernon, 1977). The most reliable drugs so far on tinnitus are intravenous procaine and lidocaine (Bárány, 1935; Lewy, 1937; Melding et al., 1978; Martin and Colman, 1980; Israel et al., 1982). The fact that these drugs cannot be given orally because of the poor biological availability after oral administration, is a great disadvantage. In view of the important pharmaco-therapeutic role of lidocaine as an anti-arrhythmic drug, considerable research has been devoted to drugs with comparable anti-arrhythmic properties but permitting oral administration. This work produced tocainide (Smith, 1981), which showed a certain degree of effect on tinnitus as well (Emmett and Shea, 1980; Cathcart, 1982). Before starting a randomized double-blind controlled trial to assess the effect on tinnitus of tocainide, we studied the effect of several doses of tocainide HCl on tinnitus in order to select an appropriate dosage. Nineteen patients with obstructive tinnitus of various aetiologies were admitted to the study. There were 10 women and nine men. Their mean age was 54 years (range 22–67 years). Tocainide was administered in five different doses in a single-blind controlled trial. To be able to judge the effect under steady conditions, each dose was given for four days, as shown in Table I. On the fourth day of each period the patients had to record the degree of impediment caused by the tinitus on a six-point scale (Table II). They were also asked to report all sideeffects.

Deramciclane in the treatment of generalized anxiety disorder: A placebo-controlled, double-blind, dose-finding study

2005 ◽  
Vol 15 (6) ◽  
pp. 617-623 ◽  
Author(s):  
Hannu Naukkarinen ◽  
Roope Raassina ◽  
Jukka Penttinen ◽  
Antti Ahokas ◽  
Riitta Jokinen ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Generalized Anxiety Disorder ◽  
Dose Finding ◽  
Generalized Anxiety ◽  
Double Blind ◽  
Finding Study ◽  
Dose Finding Study

scholarly journals 1121-58 A double-blind randomized dose finding study of gamma radiation for in-stent restenosis

2004 ◽  
Vol 43 (5) ◽  
pp. A79
Author(s):  
Paul S Teirstein ◽  
Jeffrey Moses ◽  
Martin Leon ◽  
Michael Collins ◽  
Roxanna Mehran ◽  
...  
Keyword(s):  
Gamma Radiation ◽  
Dose Finding ◽  
Double Blind ◽  
Stent Restenosis ◽  
Finding Study ◽  
Dose Finding Study ◽  
In Stent Restenosis
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