Photodynamic therapy of cervical intraepithelial neoplasia 1-3 and human papilloma virus (HPV) infection with methylaminolevulinate and hexaminolevulinate-A double-blind, dose-finding study

2012 ◽  
Vol 44 (6) ◽  
pp. 468-474 ◽  
Author(s):  
Philipp Soergel ◽  
Gunn Fallås Dahl ◽  
Mathias Onsrud ◽  
Peter Hillemanns
Keyword(s):  
Photodynamic Therapy ◽  
Human Papilloma Virus ◽  
Cervical Intraepithelial Neoplasia ◽  
Intraepithelial Neoplasia ◽  
Hpv Infection ◽  
Dose Finding ◽  
Double Blind ◽  
Papilloma Virus ◽  
Finding Study ◽  
Dose Finding Study

scholarly journals A direct comparison of four high risk human papilloma virus tests versus the cobas test for detecting cervical intraepithelial neoplasia and cervical cancer

2018 ◽  
Author(s):  
Peng Xue ◽  
Li-Li Gao ◽  
Jian Yin ◽  
Li-Li Han ◽  
Jing Zhao ◽  
...  
Keyword(s):  
Human Papilloma Virus ◽  
Cervical Intraepithelial Neoplasia ◽  
Clinical Decision Making ◽  
Intraepithelial Neoplasia ◽  
Hpv Infection ◽  
Cervical Intraepithelial Neoplasia Grade ◽  
Papilloma Virus ◽  
Clinical Sensitivity ◽  
Detection Techniques ◽  
Hpv Genotyping

ABSTRACTThis study is to evaluate performances and genotyping capabilities of four human papilloma virus (HR-HPV) tests based on real-time polymerase chain reaction (PCR) technology platforms compared with the cobas test. Discordant results were further analyzed using INNO-LiPA HPV genotyping test, the gold standard laboratory test to determine presence and type of HPV infection. Over 200 samples from Hospital patients were collected and analyzed using five HR-HPV tests. Women with positive test results were referred directly to colposcopy. If a positive result was returned, biopsies were administered for pathological classification. Clinical performances and genotyping capabilities between the four HR-HPV and cobas tests were compared and contrasted. High levels of agreement were observed, though all HR-HPV tests presented discrepancies compared with the cobas test. Cervical intraepithelial neoplasia Grade 2 or higher lesions (CIN2+) was set as the threshold, and all five tests performed with equally high sensitivity. Lower levels of specificity were observed across all five tests. Results suggest the four HR-HPV tests analyzed are as effective as the cobas test in genotyping capacities and diagnosing CIN. Therefore, these test kits should be used for HPV screening, especially in developing nations because they are cost effective and reliable. Minor discrepancies between tests are generally unavoidable though this may add complexity to the clinical decision-making process. As such, we recommend that efforts be made to standardize HPV genotyping tests as well as to optimize clinical sensitivity and specificity. Focusing on these issues will drive the development of HPV detection techniques, therefore save lives.

scholarly journals Double-blind, randomised, placebo-controlled, dose-finding study of oral ibandronate in patients with metastatic bone disease

1999 ◽  
Vol 10 (3) ◽  
pp. 311-316 ◽  
Author(s):  
R.E. Coleman ◽  
O.P. Purohit ◽  
C. Black ◽  
J.J. F. Vinholes ◽  
K. Schlosser ◽  
...  
Keyword(s):  
Bone Disease ◽  
Metastatic Bone Disease ◽  
Dose Finding ◽  
Double Blind ◽  
Finding Study ◽  
Dose Finding Study

Association of cervical intraepithelial neoplasia 2 and 3 regression by human papilloma Virus Serotype

2012 ◽  
Vol 125 ◽  
pp. S50-S51
Author(s):  
K. Harris ◽  
T. Kiet ◽  
G. Sawaya ◽  
S. Wilczynski ◽  
K. Smith-McCune ◽  
...  
Keyword(s):  
Human Papilloma Virus ◽  
Cervical Intraepithelial Neoplasia ◽  
Intraepithelial Neoplasia ◽  
Papilloma Virus ◽  
Virus Serotype

scholarly journals Photodynamic Therapy for Low-grade Cervical Intraepithelial Neoplasia (CIN1): A Case Report

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Yinyin Zhang ◽  
Hong Lin ◽  
Huizhen Fan
Keyword(s):  
Photodynamic Therapy ◽  
Cervical Intraepithelial Neoplasia ◽  
Persistent Infection ◽  
Precancerous Lesions ◽  
Irradiation Time ◽  
Intraepithelial Neoplasia ◽  
Hpv Infection ◽  
Cervical Canal ◽  
Low Grade ◽  
Oxygen Inhalation

As a drug-mechanical combination technology, photodynamic (PDT) can achieve accurate and targeted therapy for malignant tumors and benign diseases through the production of reactive oxygen species, oxygen free radicals or singlet oxygen by photosensitizers at specific wavelengths. Compared with traditional surgery, it has the advantages of selective killing, repeatable treatment, preserving target organ function and so on. The purpose of this study was to explore the clinical value of photodynamic therapy in cervical precancerous lesions by taking the patients with low-grade cervical intraepithelial neoplasia (CIN1) with high-risk human papillomavirus (HR-HPV) persistent infection diagnosed by "three-step diagnosis and treatment procedure" as an example. Using HiPorfin as a photosensitizer, photodynamic therapy was performed 48 hours after intravenous drip. Set laser wavelength 630nm, light dose density 137.58J/cm2, transmission efficiency 1.42, output power 2w. 3cm columnar optical fiber was placed around the 2cm in the cervical canal to cover all the lesions, and the irradiation time was 900s (600s in the cervical canal and 300s outside the cervical canal). The patients were given oxygen inhalation for 6 hours after operation, and the patients were observed for itching and other discomfort, and paid attention to avoid light. Photodynamic therapy was performed again in the same way on the second day. After two months of treatment, pathological biopsy showed chronic cervicitis, indicating that the disease had been effectively controlled. Theoretically, although the patient is not the absolute indication of photodynamic therapy (that is, meeting CIN ? or CIN ?, having fertility requirements and not undergoing surgery), this therapy can remove not only the superficial lesions inside and outside the cervix, but also the potential lesions not found under colposcopy. It can also block the persistent infection of HPV by inhibiting the expression of HPV18, E6 and E7mRNA in Hela cells. In combination with Baofukang suppository, it can block HPV infection. Increase the negative conversion rate of cervical HPV and reduce the probability of recurrence after CIN1 cure. For young female patients with persistent HR-HPV infection and fertility requirements, photodynamic therapy is an effective choice for clinical treatment of CIN1.

The effect of several doses of oral tocainide HC1 on tinnitus: a dose-finding study

1984 ◽  
Vol 98 (S9) ◽  
pp. 257-258
Author(s):  
Jan H. Hulshof ◽  
Pieter Vermey
Keyword(s):  
Oral Administration ◽  
Controlled Trial ◽  
Dose Finding ◽  
Double Blind ◽  
Considerable Research ◽  
Finding Study ◽  
Dose Finding Study ◽  
Single Blind ◽  
Different Doses

From all methods of the treatment of tinnitus, medical, masking, surgery, electrical stimulation and psychological, we believe a reliable medical treatment would be preferable because it is easy to apply. An immense variety of drugs have been used for the treatment of tinnitus (Vernon, 1977). The most reliable drugs so far on tinnitus are intravenous procaine and lidocaine (Bárány, 1935; Lewy, 1937; Melding et al., 1978; Martin and Colman, 1980; Israel et al., 1982). The fact that these drugs cannot be given orally because of the poor biological availability after oral administration, is a great disadvantage. In view of the important pharmaco-therapeutic role of lidocaine as an anti-arrhythmic drug, considerable research has been devoted to drugs with comparable anti-arrhythmic properties but permitting oral administration. This work produced tocainide (Smith, 1981), which showed a certain degree of effect on tinnitus as well (Emmett and Shea, 1980; Cathcart, 1982). Before starting a randomized double-blind controlled trial to assess the effect on tinnitus of tocainide, we studied the effect of several doses of tocainide HCl on tinnitus in order to select an appropriate dosage. Nineteen patients with obstructive tinnitus of various aetiologies were admitted to the study. There were 10 women and nine men. Their mean age was 54 years (range 22–67 years). Tocainide was administered in five different doses in a single-blind controlled trial. To be able to judge the effect under steady conditions, each dose was given for four days, as shown in Table I. On the fourth day of each period the patients had to record the degree of impediment caused by the tinitus on a six-point scale (Table II). They were also asked to report all sideeffects.

Human papilloma virus testing in patient follow-up post cone biopsy due to high-grade cervical intraepithelial neoplasia

2003 ◽  
Vol 88 (3) ◽  
pp. 345-350 ◽  
Author(s):  
Benny Almog ◽  
Ronni Gamzu ◽  
Michael J Kuperminc ◽  
Ishai Levin ◽  
Ofer Fainaru ◽  
...  
Keyword(s):  
Human Papilloma Virus ◽  
Cervical Intraepithelial Neoplasia ◽  
Intraepithelial Neoplasia ◽  
High Grade ◽  
Papilloma Virus ◽  
Cone Biopsy ◽  
Virus Testing
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