The protective effect ofKaempferia parvifloraextract on UVB-induced skin photoaging in hairless mice

2014 ◽  
Vol 30 (5) ◽  
pp. 237-245 ◽  
Author(s):  
Ji-Eun Park ◽  
Hee-Bong Pyun ◽  
Seon Wook Woo ◽  
Jae-Hong Jeong ◽  
Jae-Kwan Hwang
Keyword(s):  
Protective Effect ◽  
Hairless Mice ◽  
Skin Photoaging

scholarly journals Protective Effect of Fucoxanthin against UVB-Induced Skin Photoaging in Hairless Mice

2011 ◽  
Vol 75 (4) ◽  
pp. 757-760 ◽  
Author(s):  
Itaru URIKURA ◽  
Tatsuya SUGAWARA ◽  
Takashi HIRATA
Keyword(s):  
Protective Effect ◽  
Hairless Mice ◽  
Skin Photoaging

scholarly journals Protective effect of the standardized green tea seed extract on UVB-induced skin photoaging in hairless mice

2014 ◽  
Vol 8 (4) ◽  
pp. 398 ◽  
Author(s):  
Jae-Youn Lim ◽  
Ok-Kyung Kim ◽  
Jeongmin Lee ◽  
Min-Jae Lee ◽  
Namgil Kang ◽  
...  
Keyword(s):  
Protective Effect ◽  
Green Tea ◽  
Seed Extract ◽  
Hairless Mice ◽  
Skin Photoaging

Chyawanprash, a formulation of traditional Ayurvedic medicine, shows a protective effect on skin photoaging in hairless mice

2016 ◽  
Vol 14 (6) ◽  
pp. 473-479 ◽  
Author(s):  
Yuki Takauji ◽  
Kyoko Morino ◽  
Kensuke Miki ◽  
Mohammad Hossain ◽  
Dai Ayusawa ◽  
...  
Keyword(s):  
Protective Effect ◽  
Ayurvedic Medicine ◽  
Hairless Mice ◽  
Skin Photoaging

scholarly journals 4-Hydroxynonenal Contributes to Fibroblast Senescence in Skin Photoaging Evoked by UV-A Radiation

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 365 ◽  
Author(s):  
Audrey Swiader ◽  
Caroline Camaré ◽  
Paul Guerby ◽  
Robert Salvayre ◽  
Anne Negre-Salvayre
Keyword(s):  
Lipid Peroxidation ◽  
Dermal Fibroblasts ◽  
Connective Tissues ◽  
Hairless Mice ◽  
Cultured Fibroblasts ◽  
Γh2ax Foci ◽  
Skin Photoaging ◽  
Actinic Elastosis

Solar ultraviolet A (UV-A) radiation promotes a huge variety of damages on connective tissues and dermal fibroblasts, including cellular senescence, a major contributor of skin photoaging. The mechanisms of skin photoaging evoked by UV-A partly involve the generation of reactive oxygen species and lipid peroxidation. We previously reported that 4-hydroxynonenal (HNE), a lipid peroxidation-derived aldehyde, forms adducts on elastin in the skins of UV-A irradiated hairless mice, possibly contributing to actinic elastosis. In the present study, we investigated whether and how HNE promotes fibroblast senescence in skin photoaging. Dermal fibroblasts of skins from UV-A-exposed hairless mice exhibited an increased number of γH2AX foci characteristic of cell senescence, together with an accumulation of HNE adducts partly colocalizing with the cytoskeletal protein vimentin. Murine fibroblasts exposed to UV-A radiation (two cycles of 15 J/cm2), or HNE (30 µM, 4 h), exhibited senescence patterns characterized by an increased γH2AX foci expression, an accumulation of acetylated proteins, and a decreased expression of the sirtuin SIRT1. HNE adducts were detected on vimentin in cultured fibroblasts irradiated by UV-A or incubated with HNE. The HNE scavenger carnosine prevented both vimentin modification and fibroblast senescence evoked by HNE in vitro and in the skins of UV-A-exposed mice. Altogether, these data emphasize the role of HNE and lipid peroxidation-derived aldehydes in fibroblast senescence, and confirm the protective effect of carnosine in skin photoaging.

scholarly journals Protective effect of taurine on UVB-induced skin aging in hairless mice

2021 ◽  
Vol 141 ◽  
pp. 111898
Author(s):  
Tomohisa Yoshimura ◽  
Chika Manabe ◽  
Yuki Inokuchi ◽  
Chikako Mutou ◽  
Tohru Nagahama ◽  
...  
Keyword(s):  
Protective Effect ◽  
Skin Aging ◽  
Hairless Mice

Protective effect of mango (Mangifera indicaL.) against UVB-induced skin aging in hairless mice

2013 ◽  
Vol 29 (2) ◽  
pp. 84-89 ◽  
Author(s):  
Jae Hyoung Song ◽  
Eun Young Bae ◽  
Goya Choi ◽  
Jin Won Hyun ◽  
Mi Young Lee ◽  
...  
Keyword(s):  
Protective Effect ◽  
Skin Aging ◽  
Hairless Mice

scholarly journals Protective Effect of Indole-3-Pyruvate against Ultraviolet B-Induced Damage to Cultured HaCaT Keratinocytes and the Skin of Hairless Mice

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e96804 ◽  
Author(s):  
Reiji Aoki ◽  
Ayako Aoki-Yoshida ◽  
Chise Suzuki ◽  
Yoshiharu Takayama
Keyword(s):  
Protective Effect ◽  
Ultraviolet B ◽  
Hacat Keratinocytes ◽  
Hairless Mice

scholarly journals Hydrangea serrata (Thunb.) Ser. Extract Attenuate UVB-Induced Photoaging through MAPK/AP-1 Inactivation in Human Skin Fibroblasts and Hairless Mice

Nutrients ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 533 ◽  
Author(s):  
Hee-Soo Han ◽  
Ji-Sun Shin ◽  
Da-Bin Myung ◽  
Hye Ahn ◽  
Sun Lee ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Molecular Mechanisms ◽  
Mapk Signaling ◽  
Collagen Degradation ◽  
Hot Water ◽  
Mrna Levels ◽  
Skin Damage ◽  
Hairless Mice ◽  
Skin Photoaging ◽  
Mapk Signaling Pathways

Skin photoaging is mainly caused by exposure to ultraviolet (UV) light, which increases expressions of matrix metalloproteinases (MMPs) and destroys collagen fibers, consequently inducing wrinkle formation. Nutritional factors have received scientific attention for use as agents for normal skin functions. The aim of this study was to investigate the effect of hot water extracts from the leaves of Hydrangea serrata (Thunb.) Ser. (WHS) against ultraviolet B (UVB)-induced skin photoaging and to elucidate the underlying molecular mechanisms in human foreskin fibroblasts (Hs68) and HR-1 hairless mice. WHS recovered UVB-reduced cell viability and ameliorated oxidative stress by inhibiting intracellular reactive oxygen species (ROS) generation in Hs68 cells. WHS rescued UVB-induced collagen degradation by suppressing MMP expression, and reduced the mRNA levels of inflammatory cytokines. These anti-photoaging activities of WHS were associated with inhibition of the activator protein 1 (AP-1), signal transduction and activation of transcription 1 (STAT1), and mitogen-activated protein kinase (MAPK) signaling pathways. Oral administration of WHS effectively alleviated dorsal skin from wrinkle formation, epidermal thickening, collagen degradation, and skin dehydration in HR-1 hairless mice exposed to UVB. Notably, WHS suppressed UVB activation of the AP-1 and MAPK signaling pathways in dorsal mouse skin tissues. Taken together, our data indicate that WHS prevents UVB-induced skin damage due to collagen degradation and MMP activation via inactivation of MAPK/AP-1 signaling pathway.

scholarly journals Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice

Biomedicines ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 18 ◽  
Author(s):  
Xing Li ◽  
Tomohiro Matsumoto ◽  
Miho Takuwa ◽  
Mahmood Saeed Ebrahim Shaiku Ali ◽  
Takumi Hirabashi ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Skeletal Muscle ◽  
Haematococcus Pluvialis ◽  
Uv Light ◽  
Inverse Correlation ◽  
Oxygen Species ◽  
Protective Effects ◽  
Inhibitory Effects ◽  
Hairless Mice ◽  
Skin Photoaging

Ultraviolet (UV) light induces skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Astaxanthin (AST), a ketocarotenoid isolated from Haematococcus pluvialis, has been extensively studied owing to its possible effects on skin health as well as UV protection. In addition, AST attenuates the increased generation of reactive oxygen species (ROS) and capillary regression of the skeletal muscle. In this study, we investigated whether AST could protect against UV-induced photoaging and reduce capillary regression in the skin of HR-1 hairless mice. UV light induces wrinkle formation, epidermal thickening, and capillary regression in the dermis of HR-1 hairless mice. The administration of AST reduced the UV-induced wrinkle formation and skin thickening, and increased collagen fibers in the skin. AST supplementation also inhibited the generation of ROS, decreased wrinkle formation, reduced epidermal thickening, and increased the density of capillaries in the skin. We also found an inverse correlation between wrinkle formation and the density of capillaries. An association between photoaging and capillary regression in the skin was also observed. These results suggest that AST can protect against photoaging caused by UV irradiation and the inhibitory effects of AST on photoaging may be associated with the reduction of capillary regression in the skin.

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