Predictors of patient and graft survival following pediatric liver transplantation: Long‐term analysis of more than 300 cases from single centre

2021 ◽  
Author(s):  
Amr Alnagar ◽  
Khaled Daradka ◽  
Eirini Kyrana ◽  
Marumbo Methga ◽  
Karthikeyan Palaniswamy ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Graft Survival ◽  
Pediatric Liver Transplantation ◽  
Single Centre ◽  
Pediatric Liver ◽  
Term Analysis ◽  
Patient And Graft Survival

scholarly journals Recipient-Specific Risk Factors Impairing Patient and Graft Outcome after Pediatric Liver Transplantation—Analysis of 858 Transplantations in 38 Years

Children ◽  
2021 ◽  
Vol 8 (8) ◽  
pp. 641
Author(s):  
Christoph Leiskau ◽  
Norman Junge ◽  
Eva-Doreen Pfister ◽  
Imeke Goldschmidt ◽  
Frauke Mutschler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Graft Survival ◽  
Graft Loss ◽  
Single Center ◽  
Vein Thrombosis ◽  
Pediatric Liver ◽  
High Urgency ◽  
Patient And Graft Survival

(1) Background and Aim: Despite excellent long-term results in pediatric liver transplantation (pLTx), mortality and graft loss still are to be diminished. We aim to describe time-dependent changes and long-term outcome of a large single-center pLTx cohort and to identify independent recipient-related risk factors impairing patient and graft survival. (2) Methods: This is a retrospective single-center study analyzing all pediatric liver transplants from 1983–2020. Risk factors for mortality and graft loss were identified by univariable and multi-linear regression analysis. (3) Results: We analyzed 858 liver transplantations in 705 pediatric patients. Five-year patient/graft survival increased from 60.9%/48.0% (1983–1992) to 97.5%/86.5% (OR = 12.5; p < 0.0001/OR = 6.5; p < 0.0001) (2014–2020). Indications changed significantly over time, with a higher proportion of patients being transplanted for malignancies and metabolic disease and indications of PFIC and α1AT-deficiency declining. The era of transplantation (log7.378/9.657; p < 0.0001) and indication of acute liver failure (log = 1.944/2.667; HR = 2.015/1.772; p = 0.0114/0.002) impairs patient/graft survival significantly in the multivariate analysis. Furthermore, patient survival is worsened by re-transplantation (log = 1.755; HR = 1.744; p = 0.0176) and prolonged waiting times in high-urgency status (log = 2.588; HR = 1.073; p = 0.0026), whereas the indication of biliary atresia improved outcome (log = 1.502; HR = 0.575; p = 0.0315). Graft survival was additionally impaired by pre-existing portal vein thrombosis (log = 1.482; HR = 2.016; p = 0.0330). (4) Conclusions: Despite more complex indications, patient and graft survival after pLTx continue to improve.. Acute liver failure remains the indication with poorest outcome, and listing for high urgency liver transplantation should be considered carefully and early to keep waiting time on HU list short. Furthermore, pre-transplant portal vein thrombosis should be prevented whenever possible to improve graft survival.

scholarly journals Impact of donor-specific antibodies on long-term graft survival with pediatric liver transplantation

2021 ◽  
Vol 13 (6) ◽  
pp. 673-685
Author(s):  
Felicitas Leonie Schotters ◽  
Jan Beime ◽  
Andrea Briem-Richter ◽  
Thomas Binder ◽  
Uta Herden ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Graft Survival ◽  
Pediatric Liver Transplantation ◽  
Specific Antibodies ◽  
Pediatric Liver ◽  
Donor Specific Antibodies

scholarly journals Biliary complications after pediatric liver transplantation: risk factors and impact on patient and graft survival

HPB ◽  
2018 ◽  
Vol 20 ◽  
pp. S797
Author(s):  
A. Khan ◽  
M. Mendiola-Pla ◽  
B. Brecklin ◽  
N. Vachharajani ◽  
L. Dageforde ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Graft Survival ◽  
Biliary Complications ◽  
Pediatric Liver Transplantation ◽  
Pediatric Liver ◽  
Patient And Graft Survival

The Analysis of Pathological and Serological Findings in the Long-Term Pediatric Liver Transplantation

2018 ◽  
Vol 102 ◽  
pp. S896
Author(s):  
Atsushi Yoshizawa ◽  
Masakatsu Kaneshiro ◽  
Elena Uebayashi ◽  
Kumiko Suzuki ◽  
Eri Ogawa ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Pediatric Liver Transplantation ◽  
Pediatric Liver

Renal Function in Pediatric Liver Transplantation: A Long-Term Follow-Up Study

2008 ◽  
Vol 86 (8) ◽  
pp. 1028-1034 ◽  
Author(s):  
Jérôme Harambat ◽  
Bruno Ranchin ◽  
Laurence Dubourg ◽  
Aurélia Liutkus ◽  
Aoumeur Hadj-Haïssa ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Renal Function ◽  
Pediatric Liver Transplantation ◽  
Follow Up Study ◽  
Pediatric Liver ◽  
Long Term Follow Up
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