scholarly journals Neighborhood socioeconomic deprivation is associated with worse patient and graft survival following pediatric liver transplantation

2020 ◽  
Vol 20 (6) ◽  
pp. 1597-1605 ◽  
Author(s):  
Sharad I. Wadhwani ◽  
Andrew F. Beck ◽  
John Bucuvalas ◽  
Laura Gottlieb ◽  
Uma Kotagal ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Graft Survival ◽  
Socioeconomic Deprivation ◽  
Pediatric Liver Transplantation ◽  
Pediatric Liver ◽  
Patient And Graft Survival

scholarly journals Biliary complications after pediatric liver transplantation: risk factors and impact on patient and graft survival

HPB ◽  
2018 ◽  
Vol 20 ◽  
pp. S797
Author(s):  
A. Khan ◽  
M. Mendiola-Pla ◽  
B. Brecklin ◽  
N. Vachharajani ◽  
L. Dageforde ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Graft Survival ◽  
Biliary Complications ◽  
Pediatric Liver Transplantation ◽  
Pediatric Liver ◽  
Patient And Graft Survival

Graft survival in pediatric liver transplantation

2001 ◽  
Vol 36 (8) ◽  
pp. 1205-1209 ◽  
Author(s):  
Max R. Langham ◽  
Andreas G. Tzakis ◽  
Regino Gonzalez-Peralta ◽  
John F. Thompson ◽  
Charles B. Rosen ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Graft Survival ◽  
Pediatric Liver Transplantation ◽  
Pediatric Liver

Current Practice in Immunosuppression in Pediatric Liver Transplantation

2020 ◽  
Vol 26 (28) ◽  
pp. 3402-3405
Author(s):  
Rodrigo Vincenzi ◽  
Eduardo A. Fonseca ◽  
Karina M. O. Roda ◽  
Paulo Chapchap ◽  
João Seda Neto
Keyword(s):  
Liver Transplantation ◽  
Pediatric Liver Transplantation ◽  
Transplant Recipients ◽  
Live Donors ◽  
Pediatric Liver ◽  
Liver Transplant Recipients ◽  
Pediatric Recipients ◽  
Graft Selection ◽  
Pediatric Liver Transplant ◽  
Patient And Graft Survival

The last decades have witnessed a significant improvement in the field of pediatric liver transplantation (LT), resulting in longer patient and graft survival; adequate graft selection, surgical refinement, the use of live donors and optimal postoperative care are among the reasons why pediatric recipients are living longer. With this new condition, pediatric recipients are now more exposed to the deleterious effects of immunosuppression, including metabolic, infectious and neoplastic complications, nephrotoxicity and neurotoxicity. Due to all those particularities, the approach to avoid overimmunosuppression or underimmunosuppression may be more difficult in children than in adult recipients. Moreover, pediatric recipients are exposed to growth issues and specific problems during adolescence, like nonadherence to immunosuppressive therapy. This article highlights the current immunosuppressive strategies for pediatric liver transplant recipients.

The influence of an improved preservation solution On prognostic factors for graft survival in pediatric liver transplantation

1992 ◽  
Vol 5 ◽  
pp. S325-S326 ◽  
Author(s):  
P. M. J. G. Peeters ◽  
E. M. ten Verged ◽  
S. Pisarski ◽  
C. M. A. Bijleveld ◽  
R. P. Bleichrodt ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Prognostic Factors ◽  
Graft Survival ◽  
Pediatric Liver Transplantation ◽  
Preservation Solution ◽  
Pediatric Liver

scholarly journals Recipient-Specific Risk Factors Impairing Patient and Graft Outcome after Pediatric Liver Transplantation—Analysis of 858 Transplantations in 38 Years

Children ◽  
2021 ◽  
Vol 8 (8) ◽  
pp. 641
Author(s):  
Christoph Leiskau ◽  
Norman Junge ◽  
Eva-Doreen Pfister ◽  
Imeke Goldschmidt ◽  
Frauke Mutschler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Graft Survival ◽  
Graft Loss ◽  
Single Center ◽  
Vein Thrombosis ◽  
Pediatric Liver ◽  
High Urgency ◽  
Patient And Graft Survival

(1) Background and Aim: Despite excellent long-term results in pediatric liver transplantation (pLTx), mortality and graft loss still are to be diminished. We aim to describe time-dependent changes and long-term outcome of a large single-center pLTx cohort and to identify independent recipient-related risk factors impairing patient and graft survival. (2) Methods: This is a retrospective single-center study analyzing all pediatric liver transplants from 1983–2020. Risk factors for mortality and graft loss were identified by univariable and multi-linear regression analysis. (3) Results: We analyzed 858 liver transplantations in 705 pediatric patients. Five-year patient/graft survival increased from 60.9%/48.0% (1983–1992) to 97.5%/86.5% (OR = 12.5; p < 0.0001/OR = 6.5; p < 0.0001) (2014–2020). Indications changed significantly over time, with a higher proportion of patients being transplanted for malignancies and metabolic disease and indications of PFIC and α1AT-deficiency declining. The era of transplantation (log7.378/9.657; p < 0.0001) and indication of acute liver failure (log = 1.944/2.667; HR = 2.015/1.772; p = 0.0114/0.002) impairs patient/graft survival significantly in the multivariate analysis. Furthermore, patient survival is worsened by re-transplantation (log = 1.755; HR = 1.744; p = 0.0176) and prolonged waiting times in high-urgency status (log = 2.588; HR = 1.073; p = 0.0026), whereas the indication of biliary atresia improved outcome (log = 1.502; HR = 0.575; p = 0.0315). Graft survival was additionally impaired by pre-existing portal vein thrombosis (log = 1.482; HR = 2.016; p = 0.0330). (4) Conclusions: Despite more complex indications, patient and graft survival after pLTx continue to improve.. Acute liver failure remains the indication with poorest outcome, and listing for high urgency liver transplantation should be considered carefully and early to keep waiting time on HU list short. Furthermore, pre-transplant portal vein thrombosis should be prevented whenever possible to improve graft survival.

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