A pilot study of the effects of a high‐intensity aerobic exercise session on heart rate variability and arterial compliance in adolescents with or without type 1 diabetes

2020 ◽  
Vol 21 (3) ◽  
pp. 486-495
Author(s):  
Shai Konnar D. Ansell ◽  
Megan Jester ◽  
Jeanie B. Tryggestad ◽  
Kevin R. Short
2006 ◽  
Vol 7 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Firat Kardelen ◽  
Gayaz Akcurin ◽  
Halil Ertug ◽  
Sema Akcurin ◽  
Iffet Bircan

Author(s):  
Max L. Eckstein ◽  
Othmar Moser ◽  
Norbert J. Tripolt ◽  
Peter N. Pferschy ◽  
Anna A. M. Obermayer ◽  
...  

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Daizhi Yang ◽  
Jinhua Yan ◽  
Hongrong Deng ◽  
Xubin Yang ◽  
Sihui Luo ◽  
...  

Background. To comprehensively assess the effects of metformin added to insulin on metabolic control, insulin sensitivity, and cardiovascular autonomic function in adolescents with type 1 diabetes. Materials and Methods. This was an exploratory, crossover, randomized trial conducted in adolescents with type 1 diabetes aged 12-18 years old. Participants were randomly received metformin (≤1000 mg/d) added to insulin for 24 weeks followed by insulin monotherapy for a subsequent 24 weeks or vice versa. Blood pressure, body mass index, insulin dose, estimated insulin sensitivity, glycated hemoglobin A1c (HbA1c), and lipid profiles were measured, with a 72-hour continuous glucose monitoring and 24-hour Holter monitoring performed at baseline, 24, and 50 weeks for the assessments of glucose variability and heart rate variability. Results. Seventeen patients with mean ± SD age 14.4 ± 2.3   years , body mass index 18.17 ± 1.81   kg / m 2 , median (IQR) diabetes duration 4.50 (3.58, 6.92) years, and HbA1c 9.0% (8.5%, 9.4%) were enrolled. The between-group difference in HbA1c of 0.28% (95% CI -0.39 to 0.95%) was not significant ( P = 0.40 ). Changes in body mass index, insulin dose, blood pressure, lipid profiles, and estimated insulin sensitivity were similar for metformin add-on vs. insulin monotherapy. Glucose variability also did not differ. Compared with insulin monotherapy, metformin add-on significantly increased multiple heart rate variability parameters. Conclusions. Metformin added to insulin did not improve metabolic control or glucose variability in lean/normal-weight adolescents with type 1 diabetes. However, metformin added to insulin significantly increased heart rate variability, suggesting that metformin might improve cardiovascular autonomic function in this population.


Author(s):  
Mika P. Tarvainen ◽  
Sami Nikkonen ◽  
Juha E. Peltonen ◽  
Jyrki M. Aho ◽  
Anne S. Koponen ◽  
...  

Diabetes Care ◽  
2019 ◽  
Vol 42 (4) ◽  
pp. 689-692 ◽  
Author(s):  
Marleen Olde Bekkink ◽  
Mats Koeneman ◽  
Bastiaan E. de Galan ◽  
Sebastian J. Bredie

2019 ◽  
Vol 13 (5) ◽  
pp. 919-927 ◽  
Author(s):  
Ravi Reddy ◽  
Navid Resalat ◽  
Leah M. Wilson ◽  
Jessica R. Castle ◽  
Joseph El Youssef ◽  
...  

Background: Fear of exercise related hypoglycemia is a major reason why people with type 1 diabetes (T1D) do not exercise. There is no validated prediction algorithm that can predict hypoglycemia at the start of aerobic exercise. Methods: We have developed and evaluated two separate algorithms to predict hypoglycemia at the start of exercise. Model 1 is a decision tree and model 2 is a random forest model. Both models were trained using a meta-data set based on 154 observations of in-clinic aerobic exercise in 43 adults with T1D from 3 different studies that included participants using sensor augmented pump therapy, automated insulin delivery therapy, and automated insulin and glucagon therapy. Both models were validated using an entirely new validation data set with 90 exercise observations collected from 12 new adults with T1D. Results: Model 1 identified two critical features predictive of hypoglycemia during exercise: heart rate and glucose at the start of exercise. If heart rate was greater than 121 bpm during the first 5 min of exercise and glucose at the start of exercise was less than 182 mg/dL, it predicted hypoglycemia with 79.55% accuracy. Model 2 achieved a higher accuracy of 86.7% using additional features and higher complexity. Conclusions: Models presented here can assist people with T1D to avoid exercise related hypoglycemia. The simple model 1 heuristic can be easily remembered (the 180/120 rule) and model 2 is more complex requiring computational resources, making it suitable for automated artificial pancreas or decision support systems.


2015 ◽  
Vol 7 (Suppl 1) ◽  
pp. A63 ◽  
Author(s):  
Ticiana da Silva ◽  
Luiz Rolim ◽  
Celso de Camargo Sallum Filho ◽  
Livia M Zimmermann ◽  
Fernando Malerbi ◽  
...  

2014 ◽  
Vol 32 (2) ◽  
pp. 279-285 ◽  
Author(s):  
Camila Balsamo Gardim ◽  
Bruno Affonso P. de Oliveira ◽  
Aline Fernanda B. Bernardo ◽  
Rayana Loch Gomes ◽  
Francis Lopes Pacagnelli ◽  
...  

OBJECTIVE:To gather current information about the effects of type 1 diabetes mellitus on children's cardiac autonomic behavior.DATA SOURCES: The search of articles was conducted on PubMed, Ibecs, Medline, Cochrane, Lilacs, SciELO and PEDro databases using the MeSH terms: "autonomic nervous system", "diabetes mellitus", "child", "type 1 diabetes mellitus", "sympathetic nervous system" and "parasympathetic nervous system", and their respective versions in Portuguese (DeCS). Articles published from January 2003 to February 2013 that enrolled children with 9-12 years old with type 1 diabetes mellitus were included in the review.DATA SYNTHESIS: The electronic search resulted in four articles that approached the heart rate variability in children with type 1 diabetes mellitus, showing that, in general, these children present decreased global heart rate variability and vagal activity. The practice of physical activity promoted benefits for these individuals.CONCLUSIONS: Children with type 1 diabetes mellitus present changes on autonomic modulation, indicating the need for early attention to avoid future complications in this group.


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