Blood pressure regulation determined by ambulatory blood pressure profiles in children and adolescents with type 1 diabetes mellitus: Impact on diabetic complications

2017 ◽  
Vol 18 (8) ◽  
pp. 874-882 ◽  
Author(s):  
A Dost ◽  
S Bechtold-Dalla Pozza ◽  
E Bollow ◽  
R Kovacic ◽  
P Vogel ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Ambulatory Blood Pressure ◽  
Diabetic Complications ◽  
Pressure Regulation ◽  
Pressure Profiles

Autonomic blood pressure control in children and adolescents with type 1 diabetes mellitus

2009 ◽  
Vol 10 (4) ◽  
pp. 255-263 ◽  
Author(s):  
Margit Krause ◽  
Heinz Rüdiger ◽  
Martin Bald ◽  
Andrea Näke ◽  
Ekkehart Paditz
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Blood Pressure Control ◽  
Pressure Control

Impaired short-term blood pressure regulation and autonomic dysbalance in children with type 1 diabetes mellitus

Diabetologia ◽  
2007 ◽  
Vol 50 (12) ◽  
pp. 2417-2423 ◽  
Author(s):  
R. Dalla Pozza ◽  
S. Bechtold ◽  
W. Bonfig ◽  
S. Putzker ◽  
R. Kozlik-Feldmann ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Blood Pressure Regulation ◽  
Pressure Regulation ◽  
Short Term

scholarly journals Hyperfiltration, urinary albumin excretion, and ambulatory blood pressure in adolescents with Type 1 diabetes mellitus

2018 ◽  
Vol 314 (4) ◽  
pp. F667-F674 ◽  
Author(s):  
Julie A. Lovshin ◽  
Marko Škrtić ◽  
Petter Bjornstad ◽  
Rahim Moineddin ◽  
Denis Daneman ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Ambulatory Blood Pressure ◽  
Blood Pressure Monitoring ◽  
Urinary Albumin ◽  
Rapid Decline

Adolescents with Type 1 diabetes mellitus (T1DM) are at risk for hyperfiltration and elevated urinary albumin-to-creatinine ratio (ACR), which are early indicators of diabetic nephropathy. Adolescents with T1DM also develop early changes in blood pressure, cardiovascular structure, and function. Our aims were to define the relationships between hyperfiltration, ACR, and 24-h ambulatory blood pressure over time in adolescents with T1DM. Normotensive, normoalbuminuric adolescents ( n = 98) with T1DM underwent baseline and 2-yr 24-h ambulatory blood pressure monitoring, glomerular filtration rate (eGFR) estimated by cystatin C (Larsson equation), and ACR measurements. Linear regression models adjusted for diabetes duration, sex, and HbA1c were used to determine associations. Hyperfiltration (eGFR ≥ 133 ml/min) was present in 31% at baseline and 21% at 2-yr follow-up. Hyperfiltration was associated with greater odds of rapid GFR decline (>3 ml·min−1·yr−1) [OR: 5.33, 95%; CI: 1.87–15.17; P = 0.002] over 2 yr. Natural log of ACR at baseline was associated with greater odds of hyperfiltration (OR: 1.71, 95% CI: 1.00–2.92; P = 0.049) and 2-yr follow-up (OR: 2.14, 95%; CI: 1.09–4.19; P = 0.03). One SD increase in eGFR, but not ln ACR, at 2-yr follow-up conferred greater odds of nighttime nondipping pattern (OR: 1.96, 95% CI: 1.06–3.63; P = 0.03). Hyperfiltration was prevalent at baseline and at 2-yr follow-up, predicted rapid decline in GFR, and was related to ACR. Elevated GFR at 2-yr follow-up was associated with nighttime nondipping pattern. More work is needed to better understand early relationships between renal hemodynamic and systemic hemodynamic changes in adolescents with T1DM to reduce future cardiorenal complications.

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