Factors contributing to partial remission in type 1 diabetes: analysis based on the insulin dose-adjusted HbA1c in 3657 children and adolescents from Germany and Austria

2016 ◽  
Vol 18 (6) ◽  
pp. 428-434 ◽  
Author(s):  
Katrin Nagl ◽  
Julia M. Hermann ◽  
Michaela Plamper ◽  
Carmen Schröder ◽  
Axel Dost ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
Partial Remission ◽  
Insulin Dose

Partial remission in children and adolescents with type 1 diabetes: an analysis based on the insulin dose-adjusted hemoglobin A1c

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Emine Ayça Cimbek ◽  
Aydın Bozkır ◽  
Deniz Usta ◽  
Nazım Ercüment Beyhun ◽  
Ayşenur Ökten ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Partial Remission ◽  
Hemoglobin A1c ◽  
Insulin Dose ◽  
Age At Onset ◽  
Insulin Requirement ◽  
C Peptide ◽  
Factors Associated ◽  
Daily Insulin

Abstract Objectives Most patients with type 1 diabetes (T1D) experience a transient phase of partial remission (PR). This study aimed to identify the demographic and clinical factors associated with PR. Methods This was a longitudinal retrospective cohort study of 133 children and adolescents with T1D. PR was defined by the gold standard insulin dose-adjusted hemoglobin A1c (HbA1c) (IDAA1c) of ≤9. Results Remission was observed in 77 (57.9%) patients. At diagnosis, remitters had significantly higher pH (7.3 ± 0.12 vs. 7.23 ± 0.15, p=0.003), higher C-peptide levels (0.45 ± 0.31 ng/mL vs. 0.3 ± 0.22, p=0.003), and they were significantly older (9.3 ± 3.6 years vs. 7.3 ± 4.2, p=0.008) compared with non-remitters. PR developed more frequently in patients without diabetic ketoacidosis (DKA) (p=0.026) and with disease onset after age 5 (p=0.001). Patients using multiple daily insulin regimen were more likely to experience PR than those treated with a twice daily regimen (63.9 vs. 32%, p=0.004). Only age at onset was an independent predictor of PR (OR: 1.12, 95% CI: 1-1.25; p=0.044). Remitters had lower HbA1c levels and daily insulin requirement from diagnosis until one year after diagnosis (p<0.001). PR recurred in 7 (9%) patients. The daily insulin requirement at three months was lower in remitters with PR recurrence compared to those without (0.23 ± 0.14 vs. 0.4 ± 0.17 U/kg/day, p=0.014). Conclusions Addressing factors associated with the occurrence of PR could provide a better comprehension of metabolic control in T1D. The lack of DKA and higher C-peptide levels may influence PR, but the main factor associated with PR presence was older age at onset. PR may recur in a small proportion of patients.

scholarly journals Proinsulin, GLP-1, and glucagon are associated with partial remission in children and adolescents with newly diagnosed type 1 diabetes

2011 ◽  
Vol 13 (1) ◽  
pp. 51-58 ◽  
Author(s):  
Anne Kaas ◽  
Marie Louise Max Andersen ◽  
Siri Fredheim ◽  
Philip Hougaard ◽  
Karsten Buschard ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
Partial Remission ◽  
Newly Diagnosed

Safety and metabolic impact of Ramadan fasting in children and adolescents with type 1 diabetes

2016 ◽  
Vol 29 (5) ◽  
Author(s):  
Amany El-Hawary ◽  
Nanees Salem ◽  
Ashraf Elsharkawy ◽  
Abdelhameed Metwali ◽  
Alaa Wafa ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
Insulin Dose ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Regular Insulin ◽  
Insulin Regimen ◽  
Premixed Insulin ◽  
Ramadan Fasting

AbstractAnnually, many children and adolescents with type 1 diabetes mellitus (T1DM) insist on fasting for Ramadan despite being exempted and despite knowing all the risks. We aimed to assess the safety and metabolic impact of Ramadan fasting in children with T1DM using different insulin regimens.Children with T1DM who choose to fast during Ramadan 1434/2013 (29 days) were recruited 3 months before Ramadan. They received pre-Ramadan intensive education. Three insulin regimens were included; Regimen-I (regular insulin/NPH); Regimen-II (regular insulin/insulin glargine) and Regimen-III (premixed insulin). Changes in weight, insulin dose, HbAOut of total 53 patients (24 male), 28 patients (52.8%) completed Ramadan fasting (fasting group). The remaining 25 patients were included in (broke-fasting group). Positive correlation between fructosamine changes and number of days fasted during Ramadan. Significant decrease in post-Ramadan fructosamine (<0.001) and increase in post-Ramadan total cholesterol and low density lipoprotein (LDL) levels were detected within fasting, broke-fasting and insulin regimen groups. Significant higher blood glucose at three time points, pre-Iftar, pre-Sohur and midday in Regimen-I compared to Regimen-II and Regimen-III (p=0.004).: Fasting during Ramadan is feasible and is associated with significant improvement in fructosamine level in children with T1DM using different insulin regimens. Mandatory consideration to the quality and quantity of food offered to patients with T1DM during Ramadan to guard against adverse changes in lipid profile.

scholarly journals Insulin pump therapy of type 1 diabetes mellitus in children and adolescents in the Moscow region

2009 ◽  
Vol 12 (3) ◽  
pp. 60-63
Author(s):  
Elena Efimovna Petryaykina ◽  
Olga Viktorovna Dukhareva ◽  
Irina Georgievna Rybkina ◽  
Ekaterina Alexandrovna Pronina ◽  
Tatiana Dmitrievna Mikhaylova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Insulin Pump ◽  
Insulin Dose ◽  
Insulin Pump Therapy ◽  
Pump Therapy ◽  
Daily Insulin Dose

Aim. To assess dynamics of glycated hemoglobin levels and insulin doses per kg bw in children and adolescents with poorly controlled type 1 diabetes mellitus using insulin pumps. Materials and methods. Retrospective analysis of HbA1c levels and insulin doses per kg bw in children aged 2-17 years with DM1 (mean duration 5.3?3.1) before and 18 months after onset of insulin pump therapy (Medtronic Minimed 712 and 722) with a short-acting insulin analog Novopramid (Novo Nordisk) or Humalog (Ely Lilly) given to 55 (52,4%) and 50 (47,6%) of the patients respectively. НbА1с level and mean daily insulin dose per kg bw were determined when a patient visited the doctors office every 3 months. Results. Insulin pump therapy in patients with initially poorly controlled DM1 resulted in a decrease of HbA1c from 9.8?0.8 to 7,8?0,5% within 18 months after its beginning (p

scholarly journals New Definition for the Partial Remission Period in Children and Adolescents With Type 1 Diabetes

Diabetes Care ◽  
2009 ◽  
Vol 32 (8) ◽  
pp. 1384-1390 ◽  
Author(s):  
H. B. Mortensen ◽  
P. Hougaard ◽  
P. Swift ◽  
L. Hansen ◽  
R. W. Holl ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
Partial Remission ◽  
Remission Period

Partial Remission Definition: Validation based on the insulin dose-adjusted HbA1c (IDAA1C) in 129 Danish Children with New-Onset Type 1 Diabetes

2014 ◽  
Vol 15 (7) ◽  
pp. 469-476 ◽  
Author(s):  
Marie Louise C Max Andersen ◽  
Philip Hougaard ◽  
Sven Pörksen ◽  
Lotte B Nielsen ◽  
Siri Fredheim ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Partial Remission ◽  
Insulin Dose ◽  
Onset Type ◽  
New Onset

Partial remission in Brazilian children and adolescents with type 1 diabetes. Association with a haplotype of class II human leukocyte antigen and synthesis of autoantibodies

2020 ◽  
Vol 21 (4) ◽  
pp. 606-614 ◽  
Author(s):  
Daniela S. Camilo ◽  
Fernando Pradella ◽  
Maria Fernanda Paulino ◽  
Emilio C. E. Baracat ◽  
Sofia H. Marini ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Human Leukocyte Antigen ◽  
Children And Adolescents ◽  
Partial Remission ◽  
Human Leukocyte ◽  
Class Ii ◽  
Leukocyte Antigen ◽  
Brazilian Children

Assessing Factors that Influence the Level of Glycated Hemoglobin in Children and Adolescents with Type 1 Diabetes

2018 ◽  
Vol 69 (11) ◽  
pp. 3333-3336
Author(s):  
Ileana Puiu ◽  
Alexandra Oltea Dan ◽  
Elena Anca Tartea ◽  
Otilia Constantina Rogoveanu ◽  
Elena Catalina Bica ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
Diabetes Management ◽  
Glycated Hemoglobin ◽  
Glycosylated Hemoglobin ◽  
Insulin Dose ◽  
Daily Insulin Dose ◽  
Pediatric Clinic ◽  
Positive Correlations

The aim of our study was to assess the factors that influence the level of glycated hemoglobin in children and adolescents with type 1 diabetes (T1D). This study included 122 children and adolescents suffering from T1D who were in the evidence of the First Pediatric Clinic of the Clinical Emergency County Hospital of Craiova between 2003 and 2017. If HbA1c was less than 7.50%, we included patients in the glycemic equilibrium group, and if HbA1c was greater than 7.50%, we considered patients as suffering from unbalanced diabetes. By correlating the glycosylated hemoglobin level with the different parameters used in the study, we observed large/strong positive correlations between HbA1c and duration of diabetes mellitus and also between HbA1c and patient age, HbA1c negative correlation between physical activity, medium/moderate positive correlations between HbA1c and body mass index, weight of the patients and daily insulin dose and the height of the patients included in the study did not show significant correlations. Child and adolescent diabetes management has major adult differences in both insulin and drug treatment, in general, but especially in the need of understanding, counseling and integration specific to these ages.

Sign in / Sign up

Export Citation Format

Share Document