Partial Remission Definition: Validation based on the insulin dose-adjusted HbA1c (IDAA1C) in 129 Danish Children with New-Onset Type 1 Diabetes

2014 ◽  
Vol 15 (7) ◽  
pp. 469-476 ◽  
Author(s):  
Marie Louise C Max Andersen ◽  
Philip Hougaard ◽  
Sven Pörksen ◽  
Lotte B Nielsen ◽  
Siri Fredheim ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Partial Remission ◽  
Insulin Dose ◽  
Onset Type ◽  
New Onset

scholarly journals Leptin in Children with Newly Diagnosed Type 1 Diabetes: Effect of Insulin Therapy

2001 ◽  
Vol 2 (2) ◽  
pp. 121-127 ◽  
Author(s):  
Kenneth L. McCormick ◽  
Gail J. Mick ◽  
Lisa Butterfield ◽  
Hugh Ross ◽  
Elaine Parton ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Insulin Therapy ◽  
Serum Insulin ◽  
Insulin Dose ◽  
Newly Diagnosed ◽  
Baseline Serum ◽  
Serum Leptin ◽  
Onset Type ◽  
New Onset

Leptin, the gene product of adipose tissue that signals caloric plentitudeviacentral nervous system receptors, may also have diverse peripheral metabolic actions. Of paramount interest has been the potential interaction(s) between leptin and insulin. Insofar as insulin alters leptin secretion/action (orvice versa), dysregulation of this system could contribute to disease states such as diabetes.The purpose of this study was to examine the effect of exogenous insulin on serum leptin in children with newly-diagnosed Type 1 diabetes. Since these patients are hypoinsulinemic (insulindeplet. ed) at diagnosis, they present an ideal opportunity to examine the effect of insulin repletion on serum leptin. Seventeen patients were enrolled. At baseline (prior to insulin therapy), leptin levels were 4.3 ± 1.1ng/ml; they were not statistically related to the baseline serum insulin or illness severity. There was no significant change in serum leptin before, shortly (1–6 days) or several weeks (3–26 weeks) after insulin treatment even when the data was corrected for changes in BMI, hemoglobinA1C, and daily insulin dose. Since repletion of the insulin deficiency that is present in non-acidotic, ambulatory patients with new onset Type 1 diabetes did not alter serum leptin, these results argue against an effect of insulin on serum leptin in the absence of the acute diabetic ketoacidosis. Because as the recuperative months following the diagnosis of new onset Type 1 diabetes are marked by weight gain, the absence of a rise in serum leptin might also indicate either an adaptive (weight permissive) or pathologic (impaired secretory) deficit.

16-OR: Codesigning an Intervention for Adults with New-Onset Type 1 Diabetes to Improve Psychological and Social Adaptation

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 16-OR
Author(s):  
METTE DUE-CHRISTENSEN ◽  
LENE E. JOENSEN ◽  
SOPHIE SARRE ◽  
JULIE L. WAD ◽  
EWA ROMANCZUK ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Social Adaptation ◽  
Onset Type ◽  
New Onset

scholarly journals Association between influenza and the incidence rate of new‐onset type 1 diabetes in Japan

2021 ◽  
Author(s):  
Yuichi Nishioka ◽  
Tatsuya Noda ◽  
Sadanori Okada ◽  
Tomoya Myojin ◽  
Shinichiro Kubo ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Incidence Rate ◽  
Onset Type ◽  
New Onset

scholarly journals The potential effect of metabolic alkalosis on insulin sensitivity in an adolescent with new‐onset type 1 diabetes

2021 ◽  
Vol 9 (5) ◽  
Author(s):  
William E. Novotny ◽  
Irma Fiordalisi ◽  
Cynthia P. Keel ◽  
Glenn D. Harris
Keyword(s):  
Type 1 Diabetes ◽  
Insulin Sensitivity ◽  
Metabolic Alkalosis ◽  
Potential Effect ◽  
Onset Type ◽  
New Onset

scholarly journals Etanercept Treatment in Children With New-Onset Type 1 Diabetes: Pilot Randomized, Placebo-Controlled, Double-Blind Study: Response to Peters

Diabetes Care ◽  
2009 ◽  
Vol 32 (12) ◽  
pp. e154-e154 ◽  
Author(s):  
L. Mastrandrea ◽  
J. Yu ◽  
T. Behrens ◽  
J. Buchlis ◽  
C. Albini ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Etanercept Treatment ◽  
Onset Type ◽  
New Onset
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