Female sex, small size at birth and low family income increase the likelihood of insulin resistance in late childhood: the Healthy Growth Study

2013 ◽  
Vol 15 (1) ◽  
pp. 41-50 ◽  
Author(s):  
Yannis Manios ◽  
George Moschonis ◽  
Christopher Papandreou ◽  
Paraskevi-Eirini Siatitsa ◽  
Vassiliki Iatridi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Family Income ◽  
Late Childhood ◽  
Growth Study ◽  
Female Sex ◽  
Healthy Growth ◽  
Size At Birth

Vitamin D insufficiency is associated with insulin resistance independently of obesity in primary schoolchildren. The healthy growth study

2018 ◽  
Vol 19 (5) ◽  
pp. 866-873 ◽  
Author(s):  
George Moschonis ◽  
Odysseas Androutsos ◽  
Toine Hulshof ◽  
Maria Dracopoulou ◽  
George P Chrousos ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Vitamin D Insufficiency ◽  
Growth Study ◽  
Primary Schoolchildren ◽  
Healthy Growth

scholarly journals Identification of lifestyle patterns, including sleep deprivation, associated with insulin resistance in children: the Healthy Growth Study

2014 ◽  
Vol 68 (3) ◽  
pp. 344-349 ◽  
Author(s):  
O Androutsos ◽  
G Moschonis ◽  
C Mavrogianni ◽  
E Roma-Giannikou ◽  
G P Chrousos ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Sleep Deprivation ◽  
Growth Study ◽  
Healthy Growth ◽  
Lifestyle Patterns

scholarly journals Dietary patterns and breakfast consumption in relation to insulin resistance in children. The Healthy Growth Study

2014 ◽  
Vol 17 (12) ◽  
pp. 2790-2797 ◽  
Author(s):  
Kalliopi Karatzi ◽  
George Moschonis ◽  
Afroditi-Alexandra Barouti ◽  
Christos Lionis ◽  
George P Chrousos ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Dietary Patterns ◽  
Dietary Pattern ◽  
Primary Schools ◽  
Model Assessment ◽  
Inverse Association ◽  
Growth Study ◽  
Cross Point ◽  
Breakfast Consumption ◽  
Healthy Growth

AbstractObjectiveInsulin resistance is a significant cross-point for the manifestation of several chronic diseases in children and adults. The aim of the present study was to investigate the possible relationship of certain dietary patterns and breakfast consumption habits with insulin resistance in children.SubjectsA representative sample of 1912 schoolchildren (aged 9–13 years) participated in a cross-sectional epidemiological study, the Healthy Growth Study, which was initiated in May 2007 and completed in June 2009.SettingIt was conducted in seventy-seven primary schools in four large regions in Greece.DesignDietary intake, breakfast consumption, anthropometric and physical examination data, biochemical indices and socio-economic information collected from parents were assessed in all children. Principal components analysis was used to identify dietary patterns.ResultsA dietary pattern of increased consumption of margarine, sweets (candies, lollipops, jellies, traditional fruit in heavy syrup) and savoury snacks (chips, cheese puffs and not home-made popcorn) was associated with homeostasis model assessment of insulin resistance index (HOMA-IR; β = 0·08, P < 0·001) in multivariate models. Children in the third tertile of this dietary pattern had a 2·51 (95 % CI 1·30, 4·90) times higher risk of insulin resistance (HOMA-IR > 3·16) than those in the first tertile. Breakfast consumption had an inverse correlation with insulin resistance, but the correlation lost its significance after adjustments for waist circumference, birth weight, parental BMI and socio-economic status.ConclusionsIncreased consumption of margarine, sweets and savoury snacks, which is a common dietary pattern in childhood, was positively associated with insulin resistance, while breakfast consumption had an inverse association with HOMA-IR, in schoolchildren (aged 9–13 years). Identification of dietary behaviours that might affect insulin resistance in children offers valuable advice in cardiometabolic risk prevention strategies.

scholarly journals Association between Cluster of Lifestyle Behaviors and HOMA-IR among Adolescents: ABCD Growth Study

Medicina ◽  
2018 ◽  
Vol 54 (6) ◽  
pp. 96 ◽  
Author(s):  
André Werneck ◽  
Ricardo Agostinete ◽  
Suziane Cayres ◽  
Jacqueline Urban ◽  
Andréa Wigna ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Sleep Quality ◽  
Poor Sleep ◽  
Lifestyle Behaviors ◽  
Poor Sleep Quality ◽  
Growth Study ◽  
Tv Viewing ◽  
Body Fatness ◽  
Skipping Breakfast

Objective: To analyze the association of potential risk factors to health with body fatness and insulin resistance. Baseline measures of the ongoing longitudinal Analysis of Behaviors of Children During (ABCD) Growth Study. Materials and Methods: The sample was composed of 280 adolescents of both sexes (198 boys and 82 girls) aged from 10 to 18 years. Four risk factors were considered, as follows: no sports practice, skipping breakfast, poor sleep quality, and TV viewing. The outcomes considered were insulin resistance (HOMA-IR) and body fatness (densitometer scanner). Age, sex, maturity offset, and ethnicity were treated as covariates. Results: No sports practice and skipping breakfast were associated with higher body fatness (Sports practice: Wald: 8.786; p = 0.003. Breakfast: Wald: 9.364; p = 0.002). Poor sleep quality was related to a greater HOMA-IR index (Wald: 6.013; p = 0.014). Adolescents with ≥3 risk factors presented a higher risk of high HOMA-IR (OR = 4.89 (95%CI: 1.61 to 14.84)) than their counterparts with no risk factors. Conclusion: Lifestyle risk factors seem relevant to affect obesity and insulin resistance, while the aggregation of these risk factors affects insulin resistance, independent of adiposity.

scholarly journals Female sex hormones in relation to insulin resistance after hysterectomy: A pilot study

2019 ◽  
Vol 38 (6) ◽  
pp. 2721-2726 ◽  
Author(s):  
Lena Wijk ◽  
Olle Ljungqvist ◽  
Kerstin Nilsson
Keyword(s):  
Insulin Resistance ◽  
Pilot Study ◽  
Sex Hormones ◽  
Female Sex ◽  
Female Sex Hormones

scholarly journals Pregnancy Serum DLK1 Concentrations are associated with Indices of Insulin Resistance and Secretion

2021 ◽  
Author(s):  
Clive J Petry ◽  
Keith A Burling ◽  
Peter Barker ◽  
Ieuan A Hughes ◽  
Ken K Ong ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Transmembrane Protein ◽  
Protein A ◽  
Maternal Serum ◽  
Offspring Size ◽  
Oral Glucose ◽  
Insulinogenic Index ◽  
Glucose Tolerance Tests ◽  
Epidermal Growth ◽  
Size At Birth

Abstract Context DLK1 (delta like non-canonical notch ligand 1) is a paternally-expressed imprinted gene that encodes an epidermal growth factor repeat-containing transmembrane protein. A bioactive, truncated DLK1 protein is present in the circulation, and has roles in development and metabolism. Objective We sought to investigate links between maternal pregnancy circulating DLK1 concentrations and: (1) maternal and fetal DLK1 genotypes, (2) maternal insulin resistance and secretion and (3) offspring size at birth. Patients, design and setting We measured third trimester maternal serum DLK1 concentrations and examined their associations with parentally-transmitted fetal and maternal DLK1 genotypes, indices of maternal insulin resistance and secretion derived from 75g oral glucose tolerance tests performed around week 28 of pregnancy, and offspring size at birth in 613 pregnancies from the Cambridge Baby Growth Study. Results Maternal DLK1 concentrations were associated with the paternally-transmitted fetal DLK1 rs12147008 allele (p=7.8x10 -3) but not with maternal rs12147008 genotype (p=0.4). Maternal DLK1 concentrations were positively associated with maternal pre-pregnancy BMI (p=3.5x10 6), and (after adjustment for maternal BMI) with both maternal fasting insulin resistance (HOMA IR: p=0.01) and measures of maternal insulin secretion in response to oral glucose (insulinogenic index: p=1.2x10 -3; insulin disposition index: p=0.049). Further positive associations were found with offspring weight (p=0.02) and head circumference at birth (p=0.04). Conclusion These results are consistent with a partial paternal or placental origin for the maternal circulating DLK1 which may lead to increased maternal circulating DLK1 concentrations, stimulation of maternal insulin resistance and compensatory hyperinsulinemia during pregnancy, and the promotion of fetal growth.

Determination of the BMI threshold that predicts cardiovascular risk and insulin resistance in late childhood

2010 ◽  
Vol 88 (3) ◽  
pp. 307-313 ◽  
Author(s):  
Chanwon Kim ◽  
Bomtaeck Kim ◽  
Namseok Joo ◽  
Yongwoo Park ◽  
Hyoungjune Lim ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Cardiovascular Risk ◽  
Late Childhood

scholarly journals Infantile growth velocity and later asthma/wheeze: GENESIS and the Healthy Growth Study

2014 ◽  
Vol 43 (6) ◽  
pp. 1790-1793 ◽  
Author(s):  
G. V. Guibas ◽  
Y. Manios ◽  
G. Moschonis ◽  
P. Xepapadaki ◽  
E. Roumpedaki ◽  
...  
Keyword(s):  
Growth Velocity ◽  
Growth Study ◽  
Healthy Growth

Prevalence of childhood hypertension and hypertension phenotypes by weight status and waist circumference: The healthy growth study

2018 ◽  
Vol 24 ◽  
pp. 184
Author(s):  
Christiana Tsirimiagkou ◽  
Kalliopi Karatzi ◽  
Athanasios D. Protogerou ◽  
Georgios Moschonis ◽  
Odusseas Androutsos ◽  
...  
Keyword(s):  
Waist Circumference ◽  
Weight Status ◽  
Growth Study ◽  
Healthy Growth ◽  
Childhood Hypertension
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