scholarly journals Identification of lifestyle patterns, including sleep deprivation, associated with insulin resistance in children: the Healthy Growth Study

2014 ◽  
Vol 68 (3) ◽  
pp. 344-349 ◽  
Author(s):  
O Androutsos ◽  
G Moschonis ◽  
C Mavrogianni ◽  
E Roma-Giannikou ◽  
G P Chrousos ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Sleep Deprivation ◽  
Growth Study ◽  
Healthy Growth ◽  
Lifestyle Patterns

Vitamin D insufficiency is associated with insulin resistance independently of obesity in primary schoolchildren. The healthy growth study

2018 ◽  
Vol 19 (5) ◽  
pp. 866-873 ◽  
Author(s):  
George Moschonis ◽  
Odysseas Androutsos ◽  
Toine Hulshof ◽  
Maria Dracopoulou ◽  
George P Chrousos ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Vitamin D Insufficiency ◽  
Growth Study ◽  
Primary Schoolchildren ◽  
Healthy Growth

Female sex, small size at birth and low family income increase the likelihood of insulin resistance in late childhood: the Healthy Growth Study

2013 ◽  
Vol 15 (1) ◽  
pp. 41-50 ◽  
Author(s):  
Yannis Manios ◽  
George Moschonis ◽  
Christopher Papandreou ◽  
Paraskevi-Eirini Siatitsa ◽  
Vassiliki Iatridi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Family Income ◽  
Late Childhood ◽  
Growth Study ◽  
Female Sex ◽  
Healthy Growth ◽  
Size At Birth

scholarly journals Dietary patterns and breakfast consumption in relation to insulin resistance in children. The Healthy Growth Study

2014 ◽  
Vol 17 (12) ◽  
pp. 2790-2797 ◽  
Author(s):  
Kalliopi Karatzi ◽  
George Moschonis ◽  
Afroditi-Alexandra Barouti ◽  
Christos Lionis ◽  
George P Chrousos ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Dietary Patterns ◽  
Dietary Pattern ◽  
Primary Schools ◽  
Model Assessment ◽  
Inverse Association ◽  
Growth Study ◽  
Cross Point ◽  
Breakfast Consumption ◽  
Healthy Growth

AbstractObjectiveInsulin resistance is a significant cross-point for the manifestation of several chronic diseases in children and adults. The aim of the present study was to investigate the possible relationship of certain dietary patterns and breakfast consumption habits with insulin resistance in children.SubjectsA representative sample of 1912 schoolchildren (aged 9–13 years) participated in a cross-sectional epidemiological study, the Healthy Growth Study, which was initiated in May 2007 and completed in June 2009.SettingIt was conducted in seventy-seven primary schools in four large regions in Greece.DesignDietary intake, breakfast consumption, anthropometric and physical examination data, biochemical indices and socio-economic information collected from parents were assessed in all children. Principal components analysis was used to identify dietary patterns.ResultsA dietary pattern of increased consumption of margarine, sweets (candies, lollipops, jellies, traditional fruit in heavy syrup) and savoury snacks (chips, cheese puffs and not home-made popcorn) was associated with homeostasis model assessment of insulin resistance index (HOMA-IR; β = 0·08, P < 0·001) in multivariate models. Children in the third tertile of this dietary pattern had a 2·51 (95 % CI 1·30, 4·90) times higher risk of insulin resistance (HOMA-IR > 3·16) than those in the first tertile. Breakfast consumption had an inverse correlation with insulin resistance, but the correlation lost its significance after adjustments for waist circumference, birth weight, parental BMI and socio-economic status.ConclusionsIncreased consumption of margarine, sweets and savoury snacks, which is a common dietary pattern in childhood, was positively associated with insulin resistance, while breakfast consumption had an inverse association with HOMA-IR, in schoolchildren (aged 9–13 years). Identification of dietary behaviours that might affect insulin resistance in children offers valuable advice in cardiometabolic risk prevention strategies.

Insulin resistance induced by long-term sleep deprivation in rhesus macaques can be attenuated by Bifidobacterium

2021 ◽  
Author(s):  
Ying Zhao ◽  
Yan Shu ◽  
Ning Zhao ◽  
Zili Zhou ◽  
Xiong Jia ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Circadian Rhythm ◽  
Blood Glucose ◽  
Glucose Metabolism ◽  
Sleep Deprivation ◽  
Rhesus Macaques ◽  
Intravenous Glucose ◽  
Increased Risk ◽  
The Impact

Long-term sleep deprivation (SD) is a bad lifestyle habit, especially among specific occupational practitioners, characterized by circadian rhythm misalignment and abnormal sleep/wake cycles. SD is closely associated with an increased risk of metabolic disturbance, particularly obesity and insulin resistance. The incretin hormone, glucagon-like peptide-1 (GLP-1), is a critical insulin release determinant secreted by the intestinal L-cell upon food intake. Besides, the gut microbiota participates in metabolic homeostasis and regulates GLP-1 release in a circadian rhythm manner. As a commonly recognized intestinal probiotic, Bifidobacterium has various clinical indications regarding its curative effect. However, few studies have investigated the effect of Bifidobacterium supplementation on sleep disorders. In the present study, we explored the impact of long-term SD on the endocrine metabolism of rhesus monkeys and determined the effect of Bifidobacterium supplementation on the SD-induced metabolic status. Lipids concentrations, body weight, fast blood glucose, and insulin levels increased after SD. Furthermore, after two months of long-term SD, the intravenous glucose tolerance test (iVGTT) showed that the glucose metabolism was impaired and the insulin sensitivity decreased. Moreover, one month of Bifidobacterium oral administration significantly reduced blood glucose and attenuated insulin resistance in rhesus macaques. Overall, our results suggested that Bifidobacterium might be used to alleviate SD-induced aberrant glucose metabolism and improve insulin resistance. Also, it might help in better understanding the mechanisms governing the beneficial effects of Bifidobacterium.

scholarly journals Association between Cluster of Lifestyle Behaviors and HOMA-IR among Adolescents: ABCD Growth Study

Medicina ◽  
2018 ◽  
Vol 54 (6) ◽  
pp. 96 ◽  
Author(s):  
André Werneck ◽  
Ricardo Agostinete ◽  
Suziane Cayres ◽  
Jacqueline Urban ◽  
Andréa Wigna ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Sleep Quality ◽  
Poor Sleep ◽  
Lifestyle Behaviors ◽  
Poor Sleep Quality ◽  
Growth Study ◽  
Tv Viewing ◽  
Body Fatness ◽  
Skipping Breakfast

Objective: To analyze the association of potential risk factors to health with body fatness and insulin resistance. Baseline measures of the ongoing longitudinal Analysis of Behaviors of Children During (ABCD) Growth Study. Materials and Methods: The sample was composed of 280 adolescents of both sexes (198 boys and 82 girls) aged from 10 to 18 years. Four risk factors were considered, as follows: no sports practice, skipping breakfast, poor sleep quality, and TV viewing. The outcomes considered were insulin resistance (HOMA-IR) and body fatness (densitometer scanner). Age, sex, maturity offset, and ethnicity were treated as covariates. Results: No sports practice and skipping breakfast were associated with higher body fatness (Sports practice: Wald: 8.786; p = 0.003. Breakfast: Wald: 9.364; p = 0.002). Poor sleep quality was related to a greater HOMA-IR index (Wald: 6.013; p = 0.014). Adolescents with ≥3 risk factors presented a higher risk of high HOMA-IR (OR = 4.89 (95%CI: 1.61 to 14.84)) than their counterparts with no risk factors. Conclusion: Lifestyle risk factors seem relevant to affect obesity and insulin resistance, while the aggregation of these risk factors affects insulin resistance, independent of adiposity.

scholarly journals Infantile growth velocity and later asthma/wheeze: GENESIS and the Healthy Growth Study

2014 ◽  
Vol 43 (6) ◽  
pp. 1790-1793 ◽  
Author(s):  
G. V. Guibas ◽  
Y. Manios ◽  
G. Moschonis ◽  
P. Xepapadaki ◽  
E. Roumpedaki ◽  
...  
Keyword(s):  
Growth Velocity ◽  
Growth Study ◽  
Healthy Growth

scholarly journals A “healthy diet–optimal sleep” lifestyle pattern is inversely associated with liver stiffness and insulin resistance in patients with nonalcoholic fatty liver disease

2017 ◽  
Vol 42 (3) ◽  
pp. 250-256 ◽  
Author(s):  
Christina N. Katsagoni ◽  
George V. Papatheodoridis ◽  
Maria-Vasiliki Papageorgiou ◽  
Panagiota Ioannidou ◽  
Melanie Deutsch ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Dairy Products ◽  
Fatty Liver Disease ◽  
Liver Stiffness ◽  
Nonalcoholic Fatty Liver ◽  
High Consumption ◽  
Lifestyle Pattern ◽  
Factor Α ◽  
Necrosis Factor ◽  
Lifestyle Patterns

Several lifestyle habits have been described as risk factors for nonalcoholic fatty liver disease (NAFLD). Given that both healthy and unhealthy habits tend to cluster, the aim of this study was to identify lifestyle patterns and explore their potential associations with clinical characteristics of individuals with NAFLD. One hundred and thirty-six consecutive patients with ultrasound-proven NAFLD were included. Diet and physical activity level were assessed through appropriate questionnaires. Habitual night sleep hours and duration of midday naps were recorded. Optimal sleep duration was defined as sleep hours ≥ 7 and ≤ 9 h/day. Lifestyle patterns were identified using principal component analysis. Eight components were derived explaining 67% of total variation of lifestyle characteristics. Lifestyle pattern 3, namely high consumption of low-fat dairy products, vegetables, fish, and optimal sleep duration was negatively associated with insulin resistance (β = −1.66, P = 0.008) and liver stiffness (β = −1.62, P = 0.05) after controlling for age, sex, body mass index, energy intake, smoking habits, adiponectin, and tumor necrosis factor-α. Lifestyle pattern 1, namely high consumption of full-fat dairy products, refined cereals, potatoes, red meat, and high television viewing time was positively associated with insulin resistance (β = 1.66, P = 0.005), although this association was weakened after adjusting for adiponectin and tumor necrosis factor-α. A “healthy diet–optimal sleep” lifestyle pattern was beneficially associated with insulin resistance and liver stiffness in NAFLD patients independent of body weight status and energy intake.

Prevalence of childhood hypertension and hypertension phenotypes by weight status and waist circumference: The healthy growth study

2018 ◽  
Vol 24 ◽  
pp. 184
Author(s):  
Christiana Tsirimiagkou ◽  
Kalliopi Karatzi ◽  
Athanasios D. Protogerou ◽  
Georgios Moschonis ◽  
Odusseas Androutsos ◽  
...  
Keyword(s):  
Waist Circumference ◽  
Weight Status ◽  
Growth Study ◽  
Healthy Growth ◽  
Childhood Hypertension

scholarly journals Perinatal, sociodemographic and lifestyle correlates of increased total and visceral fat mass levels in schoolchildren in Greece: the Healthy Growth Study

2016 ◽  
Vol 20 (4) ◽  
pp. 660-670 ◽  
Author(s):  
George Moschonis ◽  
Adriana C Kaliora ◽  
Kalliopi Karatzi ◽  
Aggelos Michaletos ◽  
Christina-Paulina Lambrinou ◽  
...  
Keyword(s):  
Physical Activity ◽  
Fat Mass ◽  
Visceral Fat ◽  
Primary Schools ◽  
Growth Study ◽  
Full Data ◽  
Cross Sectional ◽  
Smoking During Pregnancy ◽  
Healthy Growth ◽  
Mass Level

AbstractObjectiveTo identify possibly independent associations of perinatal, sociodemographic and lifestyle factors with childhood total and visceral body fat.DesignA representative sample of 2655 schoolchildren (9–13 years) participated in the Healthy Growth Study, a cross-sectional epidemiological study.SettingSeventy-seven primary schools in four large regions in Greece.SubjectsA sample of 1228 children having full data on total and visceral fat mass levels, as well as on anthropometric, dietary, physical activity, physical examination, socio-economic and perinatal indices, was examined.ResultsMaternal (OR=3·03 and 1·77) and paternal obesity (OR=1·62 and 1·78), maternal smoking during pregnancy (OR=1·72 and 1·93) and rapid infant weight gain (OR=1·42 and 1·96) were significantly and positively associated with children’s increased total and visceral fat mass levels, respectively. Children’s television watching for >2 h/d (OR=1·40) and maternal pre-pregnancy obesity (OR=2·46) were associated with children’s increased total and visceral fat mass level, respectively. Furthermore, increased children’s physical activity (OR=0·66 and 0·47) were significantly and negatively associated with children’s total and visceral fat mass levels, respectively. Lastly, both father’s age >46 years (OR=0·57) and higher maternal educational level (OR=0·45) were associated with children’s increased total visceral fat mass level.ConclusionsParental sociodemographic characteristics, perinatal indices and pre-adolescent lifestyle behaviours were associated with children’s abnormal levels of total and visceral fat mass. Any future programme for childhood prevention either from the perinatal age or at late childhood should take these indices into consideration.

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