Low‐grade IVH in preterm infants causes cerebellar damage, motor, and cognitive impairment

2021 ◽  
Author(s):  
Satoshi Sakaue ◽  
Tatsuji Hasegawa ◽  
Koji Sakai ◽  
Yui Zen ◽  
Takenori Tozawa ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Preterm Infants ◽  
Low Grade ◽  
Cerebellar Damage

Effect of low grade intraventricular hemorrhage on developmental outcome of preterm infants

2007 ◽  
Vol 151 (2) ◽  
pp. e6 ◽  
Author(s):  
Claudine Vavasseur ◽  
Marie Slevin ◽  
Veronica Donoghue ◽  
J.F.A. Murphy
Keyword(s):  
Preterm Infants ◽  
Intraventricular Hemorrhage ◽  
Developmental Outcome ◽  
Low Grade

scholarly journals Cerebellar Development in Preterm Infants at Term-Equivalent Age Is Impaired after Low-Grade Intraventricular Hemorrhage

2016 ◽  
Vol 175 ◽  
pp. 86-92.e2 ◽  
Author(s):  
Hye Jin Jeong ◽  
So-Yeon Shim ◽  
Hye Jung Cho ◽  
Su Jin Cho ◽  
Dong Woo Son ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Intraventricular Hemorrhage ◽  
Cerebellar Development ◽  
Low Grade ◽  
Equivalent Age

scholarly journals Inflammation and Insulin Resistance as Risk Factors and Potential Therapeutic Targets for Alzheimer’s Disease

2021 ◽  
Vol 15 ◽  
Author(s):  
Angeles Vinuesa ◽  
Carlos Pomilio ◽  
Amal Gregosa ◽  
Melisa Bentivegna ◽  
Jessica Presa ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Insulin Resistance ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Brain Aging ◽  
Therapeutic Targets ◽  
Low Grade ◽  
Increased Risk ◽  
The Impact

Overnutrition and modern diets containing high proportions of saturated fat are among the major factors contributing to a low-grade state of inflammation, hyperglycemia and dyslipidemia. In the last decades, the global rise of type 2 diabetes and obesity prevalence has elicited a great interest in understanding how changes in metabolic function lead to an increased risk for premature brain aging and the development of neurodegenerative disorders such as Alzheimer’s disease (AD). Cognitive impairment and decreased neurogenic capacity could be a consequence of metabolic disturbances. In these scenarios, the interplay between inflammation and insulin resistance could represent a potential therapeutic target to prevent or ameliorate neurodegeneration and cognitive impairment. The present review aims to provide an update on the impact of metabolic stress pathways on AD with a focus on inflammation and insulin resistance as risk factors and therapeutic targets.

Cognitive impairment among extremely low birthweight preterm infants from 1980 to present day

2019 ◽  
Vol 39 (8) ◽  
pp. 1098-1104
Author(s):  
Benjamin Courchia ◽  
Michelle D. Berkovits ◽  
Charles R. Bauer
Keyword(s):  
Cognitive Impairment ◽  
Preterm Infants ◽  
Low Birthweight ◽  
Extremely Low Birthweight

scholarly journals Low-grade intraventricular hemorrhage and neurodevelopment at 24 months of age

2018 ◽  
Vol 28 (3) ◽  
pp. 29354
Author(s):  
Sara Peixoto ◽  
Joana Amaral ◽  
Cristina Resende ◽  
Dolores Faria ◽  
Adelaide Taborda
Keyword(s):  
Preterm Infants ◽  
Gestational Age ◽  
Intraventricular Hemorrhage ◽  
Univariate Analysis ◽  
Neurodevelopmental Outcome ◽  
Male Gender ◽  
Low Grade ◽  
Antenatal Corticosteroid ◽  
The Impact ◽  
Cranial Ultrasonography

AIMS: To evaluate the impact of low-grade intraventricular hemorrhage on neurodevelopmental outcome in preterm infants at 24 months of age.METHODS: We conducted a retrospective case-control study of infants with gestational age less than 34 weeks, admitted to a Neonatal Intensive Care Unit between January/2006 and December/2015. Cases were defined as those with low-grade intraventricular hemorrhage (grades I or II), diagnosed by cranial ultrasonography. For each case, a control with the same gestational age but without intraventricular hemorrhage was selected. Follow-up examinations of neurodevelopment were performed at 24 months of age in cases and controls using the Griffiths Mental Development Scale. Cerebral palsy, neurodevelopmental delay (developmental quotient <2 side deviations below the mean), hearing impairment and/or blindness were considered as severe neurodevelopmental impairment.RESULTS: The study included 172 preterm infants: 86 cases and 86 controls. In the univariate analysis, a difference between the two groups was identified for the following clinical findings: antenatal corticosteroid complete cycle (57% in cases vs. 80% in controls; p=0.001; OR: 0.33, 95%CI 0.17-0.64); male gender (63% cases vs. 41% controls; p=0.004; OR: 2.45, 95%CI 1.3-4.5); outborn (26% cases vs. 9% controls; p=0.005; OR: 3.3 95%CI 1.4-8.0); Clinical Risk Index for Babies higher than 5 (24% in cases vs. 12% in controls; p=0.029; OR: 2.4 95%CI 1.1-5.6); intubation in the delivery room (47% cases vs. 27% controls; p=0.007; OR: 2.38 95%CI 1.3-4.5); and neonatal sepsis (34% in cases vs. 20% in controls; p=0.039; OR: 2.1 95%CI 1.03-4.1). After logistic regression, differences were only maintained for antenatal corticosteroid (p=0.005; OR 0.34, 95%CI 0.16-0.72) and male gender (p=0.002; OR 2.9, 95%CI 1.4-5.8). A severe neurodevelopmental deficit was present in three cases (3.5%) and one control (1.2%). No statistically significant differences in outcome were found between cases and controls.CONCLUSIONS: In this sample, preterm infants with low-grade intraventricular hemorrhage diagnosed by cranial ultrasonography had no difference in early neurodevelopmental outcome when compared with controls.

Cognitive Impairment at Age 5 Years in Very Preterm Infants Born Following Premature Rupture of Membranes

2013 ◽  
Vol 163 (2) ◽  
pp. 435-440.e2 ◽  
Author(s):  
Thibault Mura ◽  
Jean-Charles Picaud ◽  
Béatrice Larroque ◽  
Florence Galtier ◽  
Stephane Marret ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Preterm Infants ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Very Preterm Infants ◽  
Very Preterm
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