Cutaneous reactions to pediatric cancer treatment part II: Targeted therapy

2020 ◽  
Author(s):  
Valerie M. Carlberg ◽  
Olivia M. T. Davies ◽  
Heather A. Brandling‐Bennett ◽  
Sarah E. S. Leary ◽  
Jennifer T. Huang ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Cancer Treatment ◽  
Pediatric Cancer ◽  
Cutaneous Reactions

Cutaneous reactions to pediatric cancer treatment: Part I. Conventional chemotherapy

2020 ◽  
Author(s):  
Dana Sous ◽  
Amy E. Armstrong ◽  
Jennifer T. Huang ◽  
Sonal Shah ◽  
Valerie M. Carlberg ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Pediatric Cancer ◽  
Conventional Chemotherapy ◽  
Cutaneous Reactions

Resveratrol as an Adjuvant for Normal Tissues Protection and Tumor Sensitization

2020 ◽  
Vol 20 (2) ◽  
pp. 130-145 ◽  
Author(s):  
Keywan Mortezaee ◽  
Masoud Najafi ◽  
Bagher Farhood ◽  
Amirhossein Ahmadi ◽  
Dheyauldeen Shabeeb ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Cancer Treatment ◽  
Cancer Cells ◽  
Clinical Studies ◽  
Normal Tissue ◽  
Medical Science ◽  
Treatment Modalities ◽  
Radiation Toxicity ◽  
Normal Tissues ◽  
Normal Tissue Toxicity

Cancer is one of the most complicated diseases in present-day medical science. Yearly, several studies suggest various strategies for preventing carcinogenesis. Furthermore, experiments for the treatment of cancer with low side effects are ongoing. Chemotherapy, targeted therapy, radiotherapy and immunotherapy are the most common non-invasive strategies for cancer treatment. One of the most challenging issues encountered with these modalities is low effectiveness, as well as normal tissue toxicity for chemo-radiation therapy. The use of some agents as adjuvants has been suggested to improve tumor responses and also alleviate normal tissue toxicity. Resveratrol, a natural flavonoid, has attracted a lot of attention for the management of both tumor and normal tissue responses to various modalities of cancer therapy. As an antioxidant and anti-inflammatory agent, in vitro and in vivo studies show that it is able to mitigate chemo-radiation toxicity in normal tissues. However, clinical studies to confirm the usage of resveratrol as a chemo-radioprotector are lacking. In addition, it can sensitize various types of cancer cells to both chemotherapy drugs and radiation. In recent years, some clinical studies suggested that resveratrol may have an effect on inducing cancer cell killing. Yet, clinical translation of resveratrol has not yielded desirable results for the combination of resveratrol with radiotherapy, targeted therapy or immunotherapy. In this paper, we review the potential role of resveratrol for preserving normal tissues and sensitization of cancer cells in combination with different cancer treatment modalities.

scholarly journals Long-term Dental Anomalies After Pediatric Cancer Treatment in Children

2018 ◽  
Author(s):  
Gülser Kılınç ◽  
Gülçin Bulut ◽  
Fahinur Ertuğrul ◽  
Hale Ören ◽  
Bengü Demirağ ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Pediatric Cancer ◽  
Dental Anomalies

Pediatric cancer treatment using radiation therapy

2015 ◽  
Vol 4 (4) ◽  
pp. 592
Author(s):  
Narayan Kharel ◽  
Ravinath Pandey
Keyword(s):  
Radiation Therapy ◽  
Cancer Treatment ◽  
Pediatric Cancer

scholarly journals Cost-Effectiveness of Pediatric Cancer Treatment in Tanzania: An Economic Analysis

2017 ◽  
Vol 3 (2_suppl) ◽  
pp. 33s-33s ◽  
Author(s):  
Anthony T. Saxton ◽  
Manisha Bhattacharya ◽  
Nestory Masalu ◽  
Henry E. Rice ◽  
Kristin Schroeder
Keyword(s):  
Cost Effectiveness ◽  
Cancer Treatment ◽  
Pediatric Cancer ◽  
Economic Benefit ◽  
Hospital Admissions ◽  
Conflicts Of Interest ◽  
Medical Center ◽  
Economic Value ◽  
Retrospective Chart Review ◽  
Cost Effectiveness Ratio

Abstract 52 Background: Despite the high burden of pediatric cancer in low- and middle-income countries, the number of facilities at which children can obtain treatment remains distressingly low. Understanding the costs and economic value of pediatric cancer treatment may assist policy makers to maximize the value of investments in health with informed resource allocation decisions. We examined the direct and indirect costs, cost-effectiveness, and societal economic benefit of diagnosing and treating children with cancer in Tanzania at the Bugando Medical Center, one of only two hospitals in the country with a pediatric oncology unit. Methods: A retrospective chart review of hospital admissions and clinic visits from January 2010 to August 2014 was performed. Costs were recorded for all items that were billed to the patient for laboratory studies, medications, imaging, pathology, surgeries, and hospital stay. Travel costs were estimated for each patient on the basis of a self-reported home address. All costs were converted from Tanzanian shillings to 2016 US dollars. Health outcomes were measured as disability-adjusted life-year (DALY) averted. We calculated the cost-effectiveness ratio of treatment versus performing no intervention as well as the societal economic benefit using a human capital approach and considering the per capita gross national product in Tanzania. Results: We identified costs for a subset of 127 patients, 64% of which were male (n = 81). Mean age at first clinical presentation was 6.9 years. Mean cost for treatment was $218 ± $145, with an average of 10.4 ± 8.9 DALYs averted per patient. Total cost-effectiveness ratio was $21/DALY, and the mean societal economic benefit was $27,118 ± $23,412. Conclusion: Our findings show that pediatric cancer treatment in Tanzania is cost-effective and offers substantial economic value. AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST No COIs from the authors.

scholarly journals A revision of the intensity of treatment rating scale: Classifying the intensity of pediatric cancer treatment

2011 ◽  
Vol 59 (1) ◽  
pp. 96-99 ◽  
Author(s):  
Anne E. Kazak ◽  
Matthew C. Hocking ◽  
Richard F. Ittenbach ◽  
Anna T. Meadows ◽  
Wendy Hobbie ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Pediatric Cancer ◽  
Rating Scale ◽  
Intensity Of Treatment

scholarly journals DNA repair targeted therapy: The past or future of cancer treatment?

2016 ◽  
Vol 160 ◽  
pp. 65-83 ◽  
Author(s):  
Navnath S. Gavande ◽  
Pamela S. VanderVere-Carozza ◽  
Hilary D. Hinshaw ◽  
Shadia I. Jalal ◽  
Catherine R. Sears ◽  
...  
Keyword(s):  
Dna Repair ◽  
Targeted Therapy ◽  
Cancer Treatment ◽  
The Past

Utility of automated counting to determine absolute neutrophil counts and absolute phagocyte counts for pediatric cancer treatment protocols

Cancer ◽  
2004 ◽  
Vol 101 (11) ◽  
pp. 2681-2686 ◽  
Author(s):  
Nobuko Hijiya ◽  
Mihaela Onciu ◽  
Scott C. Howard ◽  
Zhe Zhang ◽  
Cheng Cheng ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Pediatric Cancer ◽  
Treatment Protocols ◽  
Cancer Treatment Protocols
Sign in / Sign up

Export Citation Format

Share Document