A Patient with Trisomy 13 Mosaicism with an Unusual Skin Pigmentary Pattern and Prolonged Survival

2014 ◽  
Vol 31 (5) ◽  
pp. 580-583 ◽  
Author(s):  
Ariadna González-del Angel ◽  
Bernardette Estandia-Ortega ◽  
Alejandro Gaviño-Vergara ◽  
Marimar Sáez-de-Ocariz ◽  
María de la Luz Velasco-Hernández ◽  
...  
Keyword(s):  
Trisomy 13 ◽  
Prolonged Survival ◽  
Pigmentary Pattern

Long survival in Trisomy-13-syndrome: 21 cases including prolonged survival in two patients 11 and 19 years old

1981 ◽  
Vol 8 (2) ◽  
pp. 167-172 ◽  
Author(s):  
R. Redheendran ◽  
R. L. Neu ◽  
R. M. Bannerman ◽  
John M. Opitz
Keyword(s):  
Trisomy 13 ◽  
Prolonged Survival ◽  
Long Survival

Phylloid Pigmentary Pattern with Mosaic Trisomy 13

1997 ◽  
Vol 14 (4) ◽  
pp. 278-280 ◽  
Author(s):  
Denise Horn ◽  
Marisa Rommeck ◽  
Dietlind Sommer ◽  
Hannelore Körner
Keyword(s):  
Trisomy 13 ◽  
Mosaic Trisomy ◽  
Pigmentary Pattern

P 916. Lissencephaly and Prolonged Survival of a Male Infant with MICPCH and a Noval Mutation in the CASK Gene, Xp11.4

2018 ◽  
Author(s):  
Maria Dehmel ◽  
Gabriele Hahn ◽  
Sebastian Brenner ◽  
Sonja Walsh ◽  
Nataliya Didonato ◽  
...  
Keyword(s):  
Male Infant ◽  
Prolonged Survival

NICOLAU SYNDROME DUE TO INTRAMUSCULAR DICLOFENAC SODIUM INJECTION

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Harris I Shaafie ◽  
Soumya Agarwal ◽  
Swosti Mohanty ◽  
Chandni Jain
Keyword(s):  
Standard Treatment ◽  
Rare Complication ◽  
Diclofenac Sodium ◽  
Tissue Necrosis ◽  
Cytotoxic Effects ◽  
Direct Damage ◽  
Nicolau Syndrome ◽  
Syndrome Diagnosis ◽  
Embolia Cutis Medicamentosa ◽  
Pigmentary Pattern

Nicolau syndrome (NS) is a rare complication characterized by tissue necrosis that occurs after parenteral injection of drugs. The exact pathogenesis is uncertain, but there are several hypotheses, including direct damage to the end artery, acute vasospasm and cytotoxic effects of the drug. Severe pain in the immediate post injection period and purplish discoloration of the skin with reticulate pigmentary pattern is characteristic of this syndrome. Diagnosis is mainly clinical and there is no standard treatment for the disease. Herein, we present a rare case of NS due to Diclofenac Sodium (Voltaren®) injection in an 80-year-old female suffering from Lower Respiratory Tract Infection (LRTI) who was managed conservatively. Keywords: Nicolau Syndrome, Embolia cutis medicamentosa, Voltaren, Diclofenac sodium

Resource Utilization for Neonates with Trisomy 13 in California:

PEDIATRICS ◽  
2016 ◽  
Vol 137 (Supplement 3) ◽  
pp. 468A-468A
Author(s):  
Jiaqi Hu ◽  
Ann Philip ◽  
Philippe Friedlich ◽  
Nicholas Lynch ◽  
Ashwini Lakshmanan
Keyword(s):  
Resource Utilization ◽  
Trisomy 13

Prolonged survival of a patient with brain melanoma metastasis treated with BRAF and MEK inhibitors combination therapy

2020 ◽  
Vol 155 (2) ◽  
Author(s):  
Giulia Spallone ◽  
Virginia Garofalo ◽  
Eliseo Picchi ◽  
Rossella Pitocco ◽  
Federico Bianchi ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Prolonged Survival ◽  
Melanoma Metastasis ◽  
Mek Inhibitors

Prolonged survival in a subgroup of patients with brain metastases treated by gamma knife surgery

2005 ◽  
Vol 102 (Special_Supplement) ◽  
pp. 262-265
Author(s):  
C. P. Yu ◽  
Joel Y. C. Cheung ◽  
Josie F. K. Chan ◽  
Samuel C. L. Leung ◽  
Robert T. K. Ho
Keyword(s):  
Brain Metastases ◽  
Gamma Knife ◽  
Patient Survival ◽  
Gamma Knife Surgery ◽  
Prolonged Survival ◽  
Organ Involvement ◽  
Lesion Volume ◽  
Content Type ◽  
The Mean ◽  
Fine Print

Object. The authors analyzed the factors involved in determining prolonged survival (≥ 24 months) in patients with brain metastases treated by gamma knife surgery (GKS). Methods. Between 1995 and 2003, a total of 116 patients underwent 167 GKS procedures for brain metastases. There was no special case selection. Smaller and larger lesions were treated with different protocols. The mean patient age was 56.9 years, the mean number of initial lesions was 3.15, and the mean lesion volume was 10.45 cm.3 The mean follow-up time was 9.2 months. The median patient survival was 8.68 months. One-, 2-, 3-, 4-, and 5-year actuarial survival rates were 31.8%, 19.8%, 14.6%, 7.7%, and 6.9%, respectively. Patient age, number of lesions at presentation, and lesion volume had no influence on patient survival. Twenty-three (19.8%) patients survived for 24 months or more. Certain factors were associated with increased survival time. These were stable primary disease (21 of 23 patients), a long latency between diagnosis of the primary tumor and the occurrence of brain metastases (mean 28.4 months, median 16 months), absence of third-organ involvement, and repeated local procedures. Ten patients underwent repeated GKS (mean 3.4 per patient). Seven patients required open surgery for local treatment failures (recurrence or radiation necrosis). Two patients had both. Fifteen patients underwent repeated procedures. Conclusions. Aggressive local therapy with GKS, repeated GKS, and GKS plus surgery can achieve increased survival in a subgroup of patients with stable primary disease, no third-organ involvement, and long primary-brain secondary intervals.

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