scholarly journals Protective role of mouse mast cell tryptase Mcpt6 in melanoma

2020 ◽  
Vol 33 (4) ◽  
pp. 579-590
Author(s):  
Mirjana Grujic ◽  
Lars Hellman ◽  
Ann‐Marie Gustafson ◽  
Srinivas Akula ◽  
Fabio Rabelo Melo ◽  
...  
Keyword(s):  
Mast Cell ◽  
Protective Role ◽  
Mast Cell Tryptase ◽  
Mouse Mast Cell

scholarly journals Mouse Mast Cell Tryptase mMCP-6 Is a Critical Link between Adaptive and Innate Immunity in the Chronic Phase ofTrichinella spiralisInfection

2008 ◽  
Vol 180 (7) ◽  
pp. 4885-4891 ◽  
Author(s):  
Kichul Shin ◽  
Gerald F. M. Watts ◽  
Hans C. Oettgen ◽  
Daniel S. Friend ◽  
Alan D. Pemberton ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Mast Cell ◽  
Chronic Phase ◽  
Mast Cell Tryptase ◽  
Mouse Mast Cell ◽  
Adaptive And Innate Immunity ◽  
Critical Link

scholarly journals Pivotal Role of Mouse Mast Cell Protease 4 in the Conversion and Pressor Properties of Big-Endothelin-1

2013 ◽  
Vol 346 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Martin Houde ◽  
Marc-David Jamain ◽  
Julie Labonté ◽  
Louisane Desbiens ◽  
Gunnar Pejler ◽  
...  
Keyword(s):  
Mast Cell ◽  
Pivotal Role ◽  
Endothelin 1 ◽  
Mast Cell Protease ◽  
Mouse Mast Cell

scholarly journals Basophils preferentially express mouse mast cell protease 11 among the mast cell tryptase family in contrast to mast cells

2009 ◽  
Vol 86 (6) ◽  
pp. 1417-1425 ◽  
Author(s):  
Tsukasa Ugajin ◽  
Toshiyuki Kojima ◽  
Kaori Mukai ◽  
Kazushige Obata ◽  
Yohei Kawano ◽  
...  
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Mast Cell Tryptase ◽  
Mast Cell Protease ◽  
Mouse Mast Cell

scholarly journals The Chymase, Mouse Mast Cell Protease 4, Constitutes the Major Chymotrypsin-like Activity in Peritoneum and Ear Tissue. A Role for Mouse Mast Cell Protease 4 in Thrombin Regulation and Fibronectin Turnover

2003 ◽  
Vol 198 (3) ◽  
pp. 423-431 ◽  
Author(s):  
Elena Tchougounova ◽  
Gunnar Pejler ◽  
Magnus Åbrink
Keyword(s):  
Mast Cell ◽  
Coagulation System ◽  
Targeted Deletion ◽  
Mast Cell Protease ◽  
Mouse Mast Cell ◽  
Mast Cell Chymase ◽  
Connective Tissue Remodeling ◽  
Chymotryptic Activity ◽  
Insight Into

To gain insight into the biological role of mast cell chymase we have generated a mouse strain with a targeted deletion in the gene for mast cell protease 4 (mMCP-4), the mouse chymase that has the closest relationship to the human chymase in terms of tissue localization and functional properties. The inactivation of mMCP-4 did not affect the storage of other mast cell proteases and did not affect the number of mast cells or the mast cell morphology. However, mMCP-4 inactivation resulted in complete loss of chymotryptic activity in the peritoneum and in ear tissue, indicating that mMCP-4 is the main source of stored chymotrypsin-like protease activity at these sites. The mMCP-4 null cells showed markedly impaired ability to perform inactivating cleavages of thrombin, indicating a role for mMCP-4 in regulating the extravascular coagulation system. Further, a role for mMCP-4 in connective tissue remodeling was suggested by the inability of mMCP-4 null peritoneal cells to process endogenous fibronectin.

scholarly journals Mouse Mast Cell Protease 4 Is the Major Chymase in Murine Airways and Has a Protective Role in Allergic Airway Inflammation

2009 ◽  
Vol 183 (10) ◽  
pp. 6369-6376 ◽  
Author(s):  
Ida Waern ◽  
Sofia Jonasson ◽  
Josephine Hjoberg ◽  
Anders Bucht ◽  
Magnus Åbrink ◽  
...  
Keyword(s):  
Mast Cell ◽  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Protective Role ◽  
Mast Cell Protease ◽  
Mouse Mast Cell
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