scholarly journals ECAP‐Controlled Closed‐Loop Spinal Cord Stimulation Efficacy and Opioid Reduction over 24‐Months: Final Results of the Prospective, Multicenter, Open‐Label Avalon Study

Pain Practice ◽  
2021 ◽  
Author(s):  
Charles Brooker ◽  
Marc Russo ◽  
Michael J. Cousins ◽  
Nathan Taylor ◽  
Lewis Holford ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Stimulation ◽  
Closed Loop ◽  
Open Label

scholarly journals Sustained Long-Term Outcomes With Closed-Loop Spinal Cord Stimulation: 12-Month Results of the Prospective, Multicenter, Open-Label Avalon Study

Neurosurgery ◽  
2021 ◽  
Vol 89 (Supplement_2) ◽  
pp. S24-S24
Author(s):  
Marc Russo ◽  
Charles Brooker ◽  
Michael J Cousins ◽  
Nathan Taylor ◽  
Tillman Boesel ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Stimulation ◽  
Closed Loop ◽  
Long Term Outcomes ◽  
Open Label

scholarly journals Sustained Long-Term Outcomes With Closed-Loop Spinal Cord Stimulation: 12-Month Results of the Prospective, Multicenter, Open-Label Avalon Study

Neurosurgery ◽  
2020 ◽  
Vol 87 (4) ◽  
pp. E485-E495 ◽  
Author(s):  
Marc Russo ◽  
Charles Brooker ◽  
Michael J Cousins ◽  
Nathan Taylor ◽  
Tillman Boesel ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Pain Relief ◽  
Spinal Cord Stimulation ◽  
Closed Loop ◽  
Leg Pain ◽  
Therapeutic Window ◽  
Long Term Outcomes ◽  
Open Label ◽  
Stimulus Pulse

Abstract BACKGROUND Spinal cord stimulation (SCS) activates the dorsal column fibers using electrical stimuli. Current SCS systems function in fixed-output mode, delivering the same stimulus regardless of spinal cord (SC) activation. OBJECTIVE To present long-term outcomes of a novel closed-loop SCS system that aims to maintain the SC activation near a set target level and within a therapeutic window for each patient. SC activation is measured through the evoked compound action potential (ECAP) generated by each stimulus pulse. METHODS Fifty patients with lower back and/or leg pain who were successfully trialed received a permanent system (Evoke; Saluda Medical, Sydney, Australia). Ratings of pain (visual analog scale), quality of life, function, sleep, and medication use were collected at baseline and at each visit. SC activation levels were reported in summary statistics. The therapeutic window for each individual patient was defined as the range of ECAP amplitudes between sensation threshold and uncomfortably strong stimulation. RESULTS At 12 mo, the proportion of patients with ≥50% relief was 76.9% (back), 79.3% (leg), and 81.4% (overall), and the proportion with ≥80% pain relief was 56.4% (back), 58.6% (leg), and 53.5% (overall). Patients spent a median of 84.9% of their time with stimulation in their therapeutic window, and 68.8% (22/32) eliminated or reduced their opioid intake. Statistically significant improvements in secondary outcomes were observed. CONCLUSION The majority of patients experienced more than 80% pain relief with stable SC activation, as measured by ECAP amplitude at 12 mo, providing evidence for the long-term effectiveness of the Evoke closed-loop SCS system.

A Prospective, Open-Label, Multicenter Study to Assess the Efficacy of Spinal Cord Stimulation and Identify Patients Who Would Benefit

2012 ◽  
Vol 15 (1) ◽  
pp. 7-12 ◽  
Author(s):  
Kazuhide Moriyama ◽  
Kazushige Murakawa ◽  
Takeshi Uno ◽  
Kiyoshige Oseto ◽  
Minoru Kawanishi ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Multicenter Study ◽  
Spinal Cord Stimulation ◽  
Open Label

Effective Relief of Pain and Associated Symptoms With Closed-Loop Spinal Cord Stimulation System: Preliminary Results of the Avalon Study

2017 ◽  
Vol 21 (1) ◽  
pp. 38-47 ◽  
Author(s):  
Marc Russo ◽  
Michael J. Cousins ◽  
Charles Brooker ◽  
Nathan Taylor ◽  
Tillman Boesel ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Stimulation ◽  
Closed Loop ◽  
Preliminary Results ◽  
Associated Symptoms ◽  
Stimulation System
Sign in / Sign up

Export Citation Format

Share Document