Single bolus dexmedetomidine versus propofol for treatment of pediatric emergence delirium following general anesthesia

2021 ◽  
Author(s):  
Xuemin Han ◽  
Xin Sun ◽  
Xiaotian Liu ◽  
Qian Wang
Keyword(s):  
General Anesthesia ◽  
Emergence Delirium ◽  
Single Bolus

Effect of Recorded Maternal Voice on Emergence Delirium in Children Under General Anesthesia

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Cong Wang ◽  
Wei Wang ◽  
Shuo Wang ◽  
Rendong He ◽  
Haiqi Yang ◽  
...  
Keyword(s):  
General Anesthesia ◽  
Emergence Delirium ◽  
Maternal Voice

scholarly journals Emergence delirium is associated with increased postoperative delirium in elderly: a prospective observational study

2020 ◽  
Vol 34 (5) ◽  
pp. 675-687
Author(s):  
Yan Zhang ◽  
Shu-Ting He ◽  
Bin Nie ◽  
Xue-Ying Li ◽  
Dong-Xin Wang
Keyword(s):  
Observational Study ◽  
General Anesthesia ◽  
Postoperative Delirium ◽  
Prospective Observational Study ◽  
Confusion Assessment Method ◽  
Assessment Method ◽  
Emergence Delirium ◽  
Confusion Assessment ◽  
Increased Risk ◽  
Pacu Stay

Abstract Background The clinical significance of emergence delirium remains unclear. The purpose of this study was to investigate the association between emergence delirium and postoperative delirium in elderly after general anesthesia and surgery. Methods This prospective observational study was done in a tertiary hospital in Beijing, China. Elderly patients (65–90 years) who underwent major noncardiac surgery under general anesthesia and admitted to the postanesthesia care unit (PACU) after surgery were enrolled. Emergence delirium was assessed with the Confusion Assessment Method for the Intensive Care Unit during PACU stay. Postoperative delirium was assessed with the Confusion Assessment Method during the first 5 postoperative days. The association between emergence delirium and postoperative delirium was analyzed with a multivariable logistic regression model. Results A total of 942 patients were enrolled and 915 completed the study. Emergence delirium developed in 37.0% (339/915) of patients during PACU stay; and postoperative delirium developed in 11.4% (104/915) of patients within the first 5 postoperative days. After adjusted confounding factors, the occurrence of emergence delirium is independently associated with an increased risk of postoperative delirium (OR 1.717, 95% CI 1.078–2.735, P = 0.023). Patients with emergence delirium stayed longer in PACU and hospital after surgery, and developed more non-delirium complications within 30 days. Conclusions Emergence delirium in elderly admitted to the PACU after general anesthesia and major surgery is independently associated with an increased risk of postoperative delirium. Patients with emergence delirium had worse perioperative outcomes. Chinese Clinical Trial Registry (chictr.org.cn) ChiCTR-OOC-17012734

A comparison of emergence delirium scales following general anesthesia in children

2010 ◽  
Vol 20 (8) ◽  
pp. 704-711 ◽  
Author(s):  
SAMIRA A. BAJWA ◽  
DAVID COSTI ◽  
ALLAN M. CYNA
Keyword(s):  
General Anesthesia ◽  
Emergence Delirium

Acupuncture Therapy for Prevention of Emergence Delirium in Children Undergoing General Anesthesia

2008 ◽  
Vol 20 (3) ◽  
pp. 151-154 ◽  
Author(s):  
Anjana Kundu ◽  
Nathalia Jimenez ◽  
Anne Lynn
Keyword(s):  
Acupuncture Therapy ◽  
General Anesthesia ◽  
Emergence Delirium

scholarly journals Metabolomic Profiling of Children’s Brains Undergoing General Anesthesia with Sevoflurane and Propofol

2012 ◽  
Vol 117 (5) ◽  
pp. 1062-1071 ◽  
Author(s):  
Zvi Jacob ◽  
Haifang Li ◽  
Rany Makaryus ◽  
Shaonan Zhang ◽  
Ruth Reinsel ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Human Brain ◽  
General Anesthesia ◽  
Brain Connectivity ◽  
Pediatric Anesthesia ◽  
Metabolic Status ◽  
Resonance Spectroscopy ◽  
Emergence Delirium ◽  
Metabolomic Profiling ◽  
Rodent Brain

Background We recently applied proton magnetic resonance spectroscopy (HMRS) to investigate metabolic consequences of general anesthesia in the rodent brain, and discovered that isoflurane anesthesia was characterized by higher concentrations of lactate, glutamate, and glucose in comparison with propofol. We hypothesized that the metabolomic differences between an inhalant and intravenous anesthetic observed in the rodent brain could be reproduced in the human brain. Methods HMRS-based metabolomic profiling was applied to characterize the cerebral metabolic status of 59 children undergoing magnetic resonance imaging during anesthesia with either sevoflurane or propofol. HMRS scans were acquired in the parietal cortex after approximately 60 min of anesthesia. Upon emergence the children were assessed using the pediatric anesthesia emergence delirium scale. Results With sevoflurane anesthesia, the metabolic signature consisted of higher concentrations of lactate and glucose compared with children anesthetized with propofol. Further, a correlation and stepwise regression analysis performed on emergence delirium scores in relation to the metabolic status revealed that lactate and glucose correlated positively and total creatine negatively with the emergence delirium score. Conclusions Our results demonstrating higher glucose and lactate with sevoflurane in the human brain compared with propofol could reflect greater neuronal activity with sevofluane resulting in enhanced glutamate-neurotransmitter cycling, increased glycolysis, and lactate shuttling from astrocytes to neurons or mitochondrial dysfunction. Further, the association between emergence delirium and lactate suggests that anesthesia-induced enhanced cortical activity in the unconscious state may interfere with rapid return to "coherent" brain connectivity patterns required for normal cognition upon emergence of anesthesia.

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