scholarly journals The effect of dexmedetomidine premedication on postoperative systemic inflammatory response in children undergoing hernia repair surgery: A randomized controlled trial

2021 ◽  
Author(s):  
Zhen Du ◽  
Si‐Wei Wei ◽  
Xi‐Ying Zhang ◽  
Zhen Xiang ◽  
Shuang‐Quan Qu
Keyword(s):  
Randomized Controlled Trial ◽  
Inflammatory Response ◽  
Hernia Repair ◽  
Controlled Trial ◽  
Systemic Inflammatory Response ◽  
Randomized Controlled

scholarly journals The systemic inflammatory response following hand instrumentation versus ultrasonic instrumentation—A randomized controlled trial

2020 ◽  
Vol 47 (9) ◽  
pp. 1087-1097
Author(s):  
William Johnston ◽  
Michael Paterson ◽  
Krystyna Piela ◽  
Emily Davison ◽  
Annabel Simpson ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Inflammatory Response ◽  
Controlled Trial ◽  
Systemic Inflammatory Response ◽  
Randomized Controlled ◽  
Hand Instrumentation

scholarly journals Effect of sevoflurane on the inflammatory response during cardiopulmonary bypass in cardiac surgery: the study protocol for a randomized controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Thiago Augusto Azevedo Maranhão Cardoso ◽  
Gudrun Kunst ◽  
Caetano Nigro Neto ◽  
José de Ribamar Costa Júnior ◽  
Carlos Gustavo Santos Silva ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Inflammatory Response ◽  
Controlled Trial ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Volatile Anesthetic ◽  
Serum Levels ◽  
Randomized Controlled

Abstract Background Recent experimental evidence shows that sevoflurane can reduce the inflammatory response during cardiac surgery with cardiopulmonary bypass. However, this observation so far has not been assessed in an adequately powered randomized controlled trial. Methods We plan to include one hundred patients undergoing elective coronary artery bypass graft with cardiopulmonary bypass who will be randomized to receive either volatile anesthetics during cardiopulmonary bypass or total intravenous anesthesia. The primary endpoint of the study is to assess the inflammatory response during cardiopulmonary bypass by measuring PMN-elastase serum levels. Secondary endpoints include serum levels of other pro-inflammatory markers (IL-1β, IL-6, IL-8, TNFα), anti-inflammatory cytokines (TGFβ and IL-10), and microRNA expression in peripheral blood to achieve possible epigenetic mechanisms in this process. In addition clinical endpoints such as presence of major complications in the postoperative period and length of hospital and intensive care unit stay will be assessed. Discussion The trial may determine whether adding volatile anesthetic during cardiopulmonary bypass will attenuate the inflammatory response. Trial registration ClinicalTrials.gov NCT02672345. Registered on February 2016 and updated on June 2020.

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