scholarly journals The systemic inflammatory response following hand instrumentation versus ultrasonic instrumentation—A randomized controlled trial

2020 ◽  
Vol 47 (9) ◽  
pp. 1087-1097
Author(s):  
William Johnston ◽  
Michael Paterson ◽  
Krystyna Piela ◽  
Emily Davison ◽  
Annabel Simpson ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Inflammatory Response ◽  
Controlled Trial ◽  
Systemic Inflammatory Response ◽  
Randomized Controlled ◽  
Hand Instrumentation

scholarly journals Effect of sevoflurane on the inflammatory response during cardiopulmonary bypass in cardiac surgery: the study protocol for a randomized controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Thiago Augusto Azevedo Maranhão Cardoso ◽  
Gudrun Kunst ◽  
Caetano Nigro Neto ◽  
José de Ribamar Costa Júnior ◽  
Carlos Gustavo Santos Silva ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Inflammatory Response ◽  
Controlled Trial ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Volatile Anesthetic ◽  
Serum Levels ◽  
Randomized Controlled

Abstract Background Recent experimental evidence shows that sevoflurane can reduce the inflammatory response during cardiac surgery with cardiopulmonary bypass. However, this observation so far has not been assessed in an adequately powered randomized controlled trial. Methods We plan to include one hundred patients undergoing elective coronary artery bypass graft with cardiopulmonary bypass who will be randomized to receive either volatile anesthetics during cardiopulmonary bypass or total intravenous anesthesia. The primary endpoint of the study is to assess the inflammatory response during cardiopulmonary bypass by measuring PMN-elastase serum levels. Secondary endpoints include serum levels of other pro-inflammatory markers (IL-1β, IL-6, IL-8, TNFα), anti-inflammatory cytokines (TGFβ and IL-10), and microRNA expression in peripheral blood to achieve possible epigenetic mechanisms in this process. In addition clinical endpoints such as presence of major complications in the postoperative period and length of hospital and intensive care unit stay will be assessed. Discussion The trial may determine whether adding volatile anesthetic during cardiopulmonary bypass will attenuate the inflammatory response. Trial registration ClinicalTrials.gov NCT02672345. Registered on February 2016 and updated on June 2020.

scholarly journals The inflammatory response after laparoscopic and open pancreatoduodenectomy and the association with complications in a multicenter randomized controlled trial

HPB ◽  
2019 ◽  
Vol 21 (11) ◽  
pp. 1453-1461 ◽  
Author(s):  
Jony van Hilst ◽  
David J. Brinkman ◽  
Thijs de Rooij ◽  
Susan van Dieren ◽  
Michael F. Gerhards ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Inflammatory Response ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Multicenter Randomized Controlled Trial

scholarly journals Fluid resuscitation with lactated Ringer’s solution vs normal saline in acute pancreatitis: A triple-blind, randomized, controlled trial

2017 ◽  
Vol 6 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Enrique de-Madaria ◽  
Iván Herrera-Marante ◽  
Verónica González-Camacho ◽  
Laia Bonjoch ◽  
Noé Quesada-Vázquez ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Randomized Controlled Trial ◽  
Inflammatory Response ◽  
Controlled Trial ◽  
Ringer’S Solution ◽  
Randomized Controlled ◽  
Lactated Ringer's Solution ◽  
Sirs Criteria ◽  
Inflammatory Effect

Background Little is known regarding the optimal type of fluid resuscitation in acute pancreatitis (AP). Objective The objective of this article was to compare the effect of lactated Ringer’s solution (LR) vs normal saline (NS) in the inflammatory response in AP. Methods We conducted a triple-blind, randomized, controlled trial. Patients ≥ 18 admitted with AP were eligible. Patients were randomized to receive LR or NS. Primary outcome variables were number of systemic inflammatory response syndrome (SIRS) criteria at 24 hours, 48 hours and 72 hours and blood C-reactive protein (CRP) levels at 48 hours and 72 hours. In vitro complementary experiments were performed to further explore the interaction between pH, lactate and inflammation. Results Nineteen patients receiving LR and 21 receiving NS were analyzed. The median (p25–p75) number of SIRS criteria at 48 hours were 1 (1–2) for NS vs 1 (0–1) for LR, p = 0.060. CRP levels (mg/l) were as follows: at 48 hours NS 166 (78–281) vs LR 28 (3–124), p = 0.037; at 72 hours NS 217 (59–323) vs LR 25 (3–169), p = 0.043. In vitro, LR inhibited the induction of inflammatory phenotype of macrophages and NF-κB activation. This effect was not observed when using Ringer’s solution without lactate, suggesting a direct anti-inflammatory effect of lactate. Conclusions Lactated Ringer’s is associated with an anti-inflammatory effect in patients with acute pancreatitis.

Inflammatory response in children after laparoscopic vs open Nissen fundoplication: randomized controlled trial

2005 ◽  
Vol 40 (6) ◽  
pp. 908-914 ◽  
Author(s):  
Merrill McHoney ◽  
Simon Eaton ◽  
Angie Wade ◽  
Nigel J. Klein ◽  
Giorgio Stefanutti ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Inflammatory Response ◽  
Nissen Fundoplication ◽  
Controlled Trial ◽  
Randomized Controlled
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