Early childhood exposure to short periods of sevoflurane is not associated with later, lasting cognitive deficits

2016 ◽  
Vol 26 (10) ◽  
pp. 1018-1025 ◽  
Author(s):  
Mahtab Poor Zamany Nejat Kermany ◽  
Fatemeh Roodneshin ◽  
Niloofar Ahmadi Dizgah ◽  
Ebrahim Gerami ◽  
Esmail Riahi
Keyword(s):  
Early Childhood ◽  
Cognitive Deficits ◽  
Childhood Exposure

scholarly journals Dissecting Biological Pathways of Psychopathology using Cognitive Genomics

2021 ◽  
Author(s):  
Max Lam ◽  
Chia-Yen Chen ◽  
W. David Hill ◽  
Charley Xia ◽  
Ruoyu Tian ◽  
...  
Keyword(s):  
Early Childhood ◽  
Correlation Analysis ◽  
Cognitive Ability ◽  
Genetic Correlation ◽  
Cognitive Deficits ◽  
Cognitive Skills ◽  
Biological Pathways ◽  
General Cognitive Ability ◽  
Gene Sets ◽  
Cognitive Dimensions

Cognitive deficits are known to be related to most forms of psychopathology. Here, we perform local genetic correlation analysis as a means of identifying independent segments of the genome that show biologically interpretable pleiotropic associations between cognitive dimensions and psychopathology. We identified collective segments of the genome, which we call "meta-loci", that showed differential pleiotropic patterns for psychopathology relative to either General Cognitive Ability (GCA) or Non-Cognitive Skills (NCS). We observed that neurodevelopmental gene sets expressed during the prenatal-early childhood predominated in GCA-relevant meta-loci, while post-natal synaptic gene sets were more involved in NCS-relevant meta-loci. Notably, we found that GABA-ergic, cholinergic, and glutamatergic genes drove pleiotropic relationships within dissociable NCS meta-loci.

scholarly journals Dentine biomarkers of prenatal and early childhood exposure to manganese, zinc and lead and childhood behavior

2018 ◽  
Vol 121 ◽  
pp. 148-158 ◽  
Author(s):  
Megan K. Horton ◽  
Leon Hsu ◽  
Birgit Claus Henn ◽  
Amy Margolis ◽  
Christine Austin ◽  
...  
Keyword(s):  
Early Childhood ◽  
Childhood Behavior ◽  
Childhood Exposure ◽  
Manganese Zinc

Association of Exposure to Chinese Famine in Early Life with the Risk of Metabolic Syndrome in Adulthood

2020 ◽  
Vol 76 (2) ◽  
pp. 140-146 ◽  
Author(s):  
Yue Peng ◽  
Miaomiao Hai ◽  
Pengcheng Li ◽  
Yongjie Chen
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Early Childhood ◽  
Early Life ◽  
Lower Risk ◽  
Late Childhood ◽  
Fetal Life ◽  
Childhood Exposure ◽  
Study Results ◽  
Famine Exposure

Objective: To explore the association of famine exposure in early life with the risk of metabolic syndrome (MS) in the ­Chinese adults. Methods: Data were obtained from the wave 2009 of the China Health and Nutrition Survey. MS was identified when 3 or more of the following components happened: (1) waist circumference >90 cm in males or >85 cm in females; (2) fasting glucose ≥6.1 mmol/L; (3) systolic blood pressure ≥130 mm Hg/diabolic blood pressure ≥85 mm Hg; (4) fasting triglyceride ≥1.70 mmol/L; and (5) high-density lipids cholesterol <1.04 mmol/L. All participants were divided into 5 groups: no exposure, born after 1961; fetal life exposure, between 1959 and 1961; early childhood exposure, between 1956 and 1958; mid-childhood exposure, between 1953 and 1955; and late childhood exposure, between 1949 and 1952. A total of 2,080 subjects were included in this study. Results: In rural, famine exposure in fetal life and early childhood was associated with the lower risk of MS (p = 0.0491 and 0.0245; OR 0.583 and 0.703; and OR, 95% CI 0.341–0.998 and 0.517–0.956, respectively). But famine exposure in late childhood was associated with the higher risk of MS (p = 0.0140; OR 3.096; and OR, 95% CI 1.257–7.625). Famine exposure in early childhood was associated with the lower risk of MS (p = 0.0120; OR 0.633; and OR, 95% CI 0.443–0.904) in males. Conclusions: Famine exposure in mid- and late-childhood was associated with the higher risk of MS, especially in rural, males, and severe famine areas.

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