scholarly journals Prenatal high molecular weight phthalates and bisphenol A, and childhood respiratory and allergic outcomes

2018 ◽  
Vol 30 (1) ◽  
pp. 36-46 ◽  
Author(s):  
Kimberly Berger ◽  
Brenda Eskenazi ◽  
John Balmes ◽  
Katie Kogut ◽  
Nina Holland ◽  
...  
Author(s):  
Anna R. Smith ◽  
Katherine R. Kogut ◽  
Kimberly Parra ◽  
Asa Bradman ◽  
Nina Holland ◽  
...  

Abstract Background Phthalates and bisphenol A (BPA) are endocrine disrupting chemicals used in consumer products, building materials, and food processing and packaging materials. They are associated with adverse health outcomes, especially when exposure occurs during heightened windows of susceptibility. Objective We evaluated the relationship between housing and dietary characteristics and the concentration of several high-molecular-weight (HMW) phthalate metabolites and BPA in a cohort of Latina adolescents. Methods We collected information on recent food consumption and housing characteristics and quantified the concentration of HMW phthalate and BPA metabolites in urine collected at two different time points. We used generalized estimating equations (GEE) to assess predictors of each metabolite. Results No significant associations were observed between housing and dietary characteristics and metabolites of di(2-ethylhexyl) phthalate (DEHP) or BPA. In contrast, higher urinary monobenzyl phthalate (MBzP) concentration was associated with living in a home with vinyl or linoleum flooring (66.7% change, p-value <0.01), while higher urinary mono(3-carboxypropyl) phthalate (MCPP) concentration was associated with recent consumption of coffee (47.2% change, p-value <0.01), and fast food (30.3% change, p-value <0.05). Significance These findings may be useful in targeting interventions that reduce phthalate uptake in young adults.


2009 ◽  
Vol 41 (4) ◽  
pp. 338-342 ◽  
Author(s):  
Tadamasa Nemoto ◽  
Isamu Amir ◽  
Gen-ichi Konishi

Author(s):  
Richard B. Vallee

Microtubules are involved in a number of forms of intracellular motility, including mitosis and bidirectional organelle transport. Purified microtubules from brain and other sources contain tubulin and a diversity of microtubule associated proteins (MAPs). Some of the high molecular weight MAPs - MAP 1A, 1B, 2A, and 2B - are long, fibrous molecules that serve as structural components of the cytamatrix. Three MAPs have recently been identified that show microtubule activated ATPase activity and produce force in association with microtubules. These proteins - kinesin, cytoplasmic dynein, and dynamin - are referred to as cytoplasmic motors. The latter two will be the subject of this talk.Cytoplasmic dynein was first identified as one of the high molecular weight brain MAPs, MAP 1C. It was determined to be structurally equivalent to ciliary and flagellar dynein, and to produce force toward the minus ends of microtubules, opposite to kinesin.


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