scholarly journals The role of fish intake on asthma in children: A meta-analysis of observational studies

2018 ◽  
Vol 29 (4) ◽  
pp. 350-360 ◽  
Author(s):  
M. M. Papamichael ◽  
S. K. Shrestha ◽  
C. Itsiopoulos ◽  
B. Erbas
Keyword(s):  
Observational Studies ◽  
Meta Analysis ◽  
Fish Intake ◽  
Asthma In Children

Mechanical Thromboprophylaxis in Critically Ill Patients: A Systematic Review and Meta-Analysis

2006 ◽  
Vol 15 (4) ◽  
pp. 402-412 ◽  
Author(s):  
Anthony Limpus ◽  
Wendy Chaboyer ◽  
Ellen McDonald ◽  
Lukman Thalib
Keyword(s):  
Intensive Care ◽  
Randomized Controlled Trials ◽  
Observational Studies ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Trauma Patients ◽  
Intensive Care Patients ◽  
Randomized Controlled ◽  
Confounding Variables

• Objective To systematically review the randomized trials, observational studies, and survey evidence on compression and pneumatic devices for thromboprophylaxis in intensive care patients. • Methods Published studies on the use of compression and pneumatic devices in intensive care patients were assessed. A meta-analysis was conducted by using the randomized controlled trials. • Results A total of 21 relevant studies (5 randomized controlled trials, 13 observational studies, and 3 surveys) were found. A total of 811 patients were randomized in the 5 randomized controlled trials; 3421 patients participated in the observational studies. Trauma patients only were enrolled in 4 randomized controlled trials and 4 observational studies. Meta-analysis of 2 randomized controlled trials with similar populations and outcomes revealed that use of compression and pneumatic devices did not reduce the incidence of venous thromboembolism. The pooled risk ratio was 2.37, indicative of favoring the control over the intervention in reducing the deep venous thrombosis; however, the 95% CI of 0.57 to 9.90 indicated no significant differences between the intervention and the control. A range of methodological issues, including bias and confounding variables, make meaningful interpretation of the observational studies difficult. • Conclusions The limited evidence suggests that use of compressive and pneumatic devices yields results not significantly different from results obtained with no treatment or use of low-molecular-weight heparin. Until large randomized controlled trials are conducted, the role of mechanical approaches to thromboprophylaxis for intensive care patients remains uncertain.

scholarly journals Trimethylamine N-Oxide in Relation to Cardiometabolic Health—Cause or Effect?

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1330 ◽  
Author(s):  
Christopher Papandreou ◽  
Margret Moré ◽  
Aouatef Bellamine
Keyword(s):  
Observational Studies ◽  
Animal Studies ◽  
Disease Model ◽  
Fish Intake ◽  
Model Systems ◽  
Cardiometabolic Health ◽  
Epidemiological Evidence ◽  
Cardiometabolic Diseases ◽  
Beneficial Effects

Trimethylamine-N-oxide (TMAO) is generated in a microbial-mammalian co-metabolic pathway mainly from the digestion of meat-containing food and dietary quaternary amines such as phosphatidylcholine, choline, betaine, or L-carnitine. Fish intake provides a direct significant source of TMAO. Human observational studies previously reported a positive relationship between plasma TMAO concentrations and cardiometabolic diseases. Discrepancies and inconsistencies of recent investigations and previous studies questioned the role of TMAO in these diseases. Several animal studies reported neutral or even beneficial effects of TMAO or its precursors in cardiovascular disease model systems, supporting the clinically proven beneficial effects of its precursor, L-carnitine, or a sea-food rich diet (naturally containing TMAO) on cardiometabolic health. In this review, we summarize recent preclinical and epidemiological evidence on the effects of TMAO, in order to shed some light on the role of TMAO in cardiometabolic diseases, particularly as related to the microbiome.

scholarly journals Association between fish intake and glioma risk: a systematic review and meta-analysis

2020 ◽  
Vol 48 (8) ◽  
pp. 030006052093969
Author(s):  
Honcho Lei ◽  
Chiho To ◽  
Unpeng Lei
Keyword(s):  
Effect Size ◽  
Observational Studies ◽  
Web Of Science ◽  
Meta Analysis ◽  
Fish Intake ◽  
Random Effects Model ◽  
Eligibility Criteria ◽  
Fresh Fish ◽  
Glioma Risk ◽  
The Relationship

Objectives We investigated the association between the consumption of fresh and processed fish and glioma risk using a meta-analysis approach. Methods We selected and analyzed observational studies that discussed the relationships between fresh and processed fish intake on glioma risk from PubMed, Web of Science, Embase, and the SinoMed and Wanfang databases from inception to 31 March 2020. Studies were selected according to pre-established eligibility criteria and data were extracted separately by two researchers. A meta-analysis was conducted based on a random-effects model to provide pooled odds ratios (OR) and 95% confidence intervals (CIs). Results Eight studies considered the relationship between fish intake (seven fresh and seven processed fish) and glioma risk and were included in this meta-analysis. The OR effect size for fresh fish intake and glioma risk was 0.72 (95%CI 0.53–0.97) and the overall OR effect size for processed fish intake and glioma risk was 1.88 (95%CI 1.06–3.34). Conclusion Dietary intake of fresh fish may reduce the risk of glioma, but consumption of processed fish may increase the risk of glioma. This study had some limitations, and further studies are therefore required to clarify the associations between fish intake and glioma risk.

scholarly journals The role of minimal access valve surgery in the elderly. A meta-analysis of observational studies

2016 ◽  
Vol 33 ◽  
pp. 164-171 ◽  
Author(s):  
Marco Moscarelli ◽  
Sam Emmanuel ◽  
Thanos Athanasiou ◽  
Giuseppe Speziale ◽  
Khalil Fattouch ◽  
...  
Keyword(s):  
Observational Studies ◽  
Meta Analysis ◽  
The Elderly ◽  
Valve Surgery ◽  
Minimal Access ◽  
Surgery In The Elderly

Poultry and fish intake and risk of esophageal cancer: A meta-analysis of observational studies

2013 ◽  
Vol 12 (1) ◽  
pp. e82-e91 ◽  
Author(s):  
Gengxi Jiang ◽  
Bailing Li ◽  
Xiaohong Liao ◽  
Chongjun Zhong
Keyword(s):  
Esophageal Cancer ◽  
Observational Studies ◽  
Meta Analysis ◽  
Fish Intake

scholarly journals Role of serum ferritin level on overall survival in patients with myelodysplastic syndromes: Results of a meta-analysis of observational studies

PLoS ONE ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. e0179016 ◽  
Author(s):  
Claudia Pileggi ◽  
Maddalena Di Sanzo ◽  
Valentina Mascaro ◽  
Maria Grazia Marafioti ◽  
Francesco Saverio Costanzo ◽  
...  
Keyword(s):  
Overall Survival ◽  
Serum Ferritin ◽  
Myelodysplastic Syndromes ◽  
Observational Studies ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Meta Analysis

scholarly journals Role of IL-17 gene polymorphisms in osteoarthritis: A meta-analysis based on observational studies

2020 ◽  
Vol 8 (11) ◽  
pp. 2280-2293
Author(s):  
Hao-Yu Yang ◽  
Yu-Zhou Liu ◽  
Xin-Die Zhou ◽  
Yong Huang ◽  
Nan-Wei Xu
Keyword(s):  
Gene Polymorphisms ◽  
Observational Studies ◽  
Meta Analysis

scholarly journals P.063 Endovascular Treatment of Acute Ischemic Stroke in Patients with Pre-morbid Disability: A Meta-analysis

2021 ◽  
Vol 48 (s3) ◽  
pp. S37-S37
Author(s):  
F Bala ◽  
B Beland ◽  
A Ganesh
Keyword(s):  
Ischemic Stroke ◽  
Endovascular Treatment ◽  
Random Effects ◽  
Observational Studies ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Endovascular Thrombectomy ◽  
Randomized Controlled ◽  
Stroke Disability

Background: Practice-changing trials of endovascular thrombectomy (EVT) for acute stroke excluded patients with pre-morbid disability. Observational studies may inform the role of EVT in this population. We performed a meta-analysis to estimate the effect of EVT in patients with pre-morbid disability. Methods: We adhered to PRISMA guidelines and searched Medline and Embase for studies describing EVT in adults with and without pre-morbid disability with stroke. Random-effects meta-analysis was used to pool outcomes, including favorable outcomes (mRS=0-2 or return to baseline), no increase in disability at 90 days, symptomatic ICH (sICH) and 90-day mortality. Results: We included 8 studies with 5570 patients (mRS 3-5=863, mRS 0-2=4,707). Patients with pre-morbid disability were more likely to return to their baseline mRS (aOR 2.53, 95% CI=1.47-4.36), although they had higher 90-day mortality (aOR=2.21, 95% CI=1.66-2.93). aOR for favorable outcome (aOR=0.83, 95% CI=0.67-1.03) or sICH (aOR=1.07, 95% CI=0.74-1.54) was not significantly different between groups. Conclusions: Observational studies suggest that EVT is safe in patients with pre-stroke disability and may result in comparable return to pre-stroke status as in patients without such disability. These findings argue against the routine exclusion of patients with pre-morbid disability from EVT and merit validation with randomized controlled trials.

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