Arrhythmogenic Evidence for Epicardial Adipose Tissue: Heart Rate Variability and Turbulence are Influenced by Epicardial Fat Thickness

2014 ◽  
Vol 38 (1) ◽  
pp. 99-106 ◽  
Author(s):  
AKİF SERHAT BALCIOĞLU ◽  
DAVRAN ÇİÇEK ◽  
SİNAN AKINCI ◽  
HALİL OLCAY ELDEM ◽  
UĞUR ABBAS BAL ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Adipose Tissue ◽  
Epicardial Adipose Tissue ◽  
Epicardial Fat ◽  
Epicardial Fat Thickness ◽  
Fat Thickness

scholarly journals Epicardial Fat Thickness as a Diagnostic Marker of Coronary Lesions in Stable Angina Pectoris Patients

2021 ◽  
Author(s):  
Ulzim Fajar ◽  
Mefri Yanni ◽  
Muhammad Syukri
Keyword(s):  
Adipose Tissue ◽  
Epicardial Adipose Tissue ◽  
Diagnostic Marker ◽  
Visceral Adiposity ◽  
Epicardial Fat ◽  
Stable Angina Pectoris ◽  
Epicardial Fat Thickness ◽  
Coronary Lesion ◽  
Fat Thickness ◽  
Coronary Lesions

  Background: Abdominal visceral adiposity is a risk factor of cardiovascular diseases. It correlates with increasing level of pro-inflammatory adipokines and cytokines which can induce endothelial dysfunction. Epicardial adipose tissue is considered as true visceral adiposity of the heart. Epicardial adipose tissue have pivotal role than other visceral adiposity because of adjacency to the heart and coronary vessels. This study was aimed to measure the cut off point of epicardial fat thickness as a diagnostic marker for the presence of coronary lesion. Methods: This was an observational analytic study with crossectional comparative design. Data was retrieved prospectively at the Heart Center Dr. M. Djamil Padang from August 2019 to February 2020 in stable angina pectoris patients who underwent coronary angiography. The Epicardial Fat Thickness (EFT) was measured at end-diastole from the Parasternal long axis (PLAX) views of three cardiac cycles on the free wall of the right ventricle on echocardiography examination. Bivariate analysis was used to assess epicardial fat thickness and presence of the coronary lesions using Independent Sample T test. A diagnostic test was performed based on receiver operating curve (ROC) analysis. Results: Patients were diagnosed as CAD group group (n =150; 58,11 ± 8,24 years) and non-CAD group (n = 50; 53,16 ± 9,78 years) based on coronary angiogram result. Epicardial fat thickness was higher in subjects with coronary lesions (3,62 ± 1,03 mm) compared with subjects without coronary lesions (1,55 ± 1,10 mm) with p <0.001. Epicardial fat thickness ≥ 2.835 mm predict the presence of coronary lesion by 82% sensitivity, 86% specificity and 88.9% accuracy based on the AUC value. Conclusions: Abnormal epicardial fat thickness ≥ 2.835 mm can be a good diagnostic marker to detect the presence of coronary lesion. 

scholarly journals Correlation between Echocardiographic Epicardial Fat Thickness and Angiographic Severity of Coronary Artery Disease

2018 ◽  
Vol 33 (1) ◽  
pp. 47-53
Author(s):  
Shahid Mohammad Omar Faroque ◽  
Abdul Wadud Chowdhury ◽  
Mohsin Ahmed ◽  
Khandker Md Nurus Sabah ◽  
Mohammad Khalilur Rahman Siddiqui ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Adipose Tissue ◽  
Coronary Artery ◽  
Coronary Arteries ◽  
Epicardial Fat ◽  
Epicardial Fat Thickness ◽  
Normal Coronary Arteries ◽  
Single Vessel ◽  
Fat Thickness ◽  
Artery Disease

Background: Epicardial adipose tissue (EAT) is a visceral adipose tissue surrounding the heart and the coronary arteries. Because of its endocrine and paracrine activity, secreting pro-inflammatory and antiinflammatory cytokines and chemokines, it has been suggested to influence coronary atherosclerosis development.Objectives: To identify the relationship between echocardiographic epicardial fat thickness and the extent of coronary artery disease (CAD). Methods: Considering the inclusion and exclusion criteria, a total 87 patients with established or suspected coronary artery disease admitted for coronary angiogram were included in this study. After taking written consent, initial evaluation of the patients was done by history, clinical examination and relevant investigation. Variables, risk factors for CAD and investigation reports were recorded in data sheet. Echocardiography and coronary angiography were done. EAT thickness measurements by echocardiography were compared with coronary angiographic findings.Results: Echocardiographic EAT thickness was significantly higher in patients with CAD in comparison to those with normal coronary arteries 7.14±1.81 mm vs 4.08±1.06mm (p <0.001). Furthermore, EAT thickness increase with the severity of CAD. EAT is 4.08±1.06 mm in patients with normal/non-significant CAD (n=20), 5.75±0.96 mm in single vessel CAD (n=24), 6.54±1.09 mm in double vessel CAD (n=16) and 8.75±1.45 mm in patients with triple vessel CAD (n=27).Conclusions:EAT thickness was significantly higher in patients with angiographically detected CAD in comparison to those with normal coronary arteries. Furthermore, EAT thickness increased with the severity of CAD; i.e. it was thicker in multivessel coronary artery disease than in single vessel or non-significant coronary artery disease.Bangladesh Heart Journal 2018; 33(1) : 47-53

Epicardial fat thickness in infants of diabetic mothers

2021 ◽  
pp. 1-6
Author(s):  
M.M. Vela-Huerta ◽  
N. Amador-Licona ◽  
R. Domínguez-Damiá ◽  
A. Heredia-Ruiz ◽  
H.V. Orozco-Villagomez ◽  
...  
Keyword(s):  
Interventricular Septum ◽  
Left Ventricular ◽  
Epicardial Fat ◽  
Left Ventricular Ejection ◽  
Epicardial Fat Thickness ◽  
Infants Of Diabetic Mothers ◽  
Significant Difference ◽  
Echocardiographic Parameters ◽  
Fat Thickness ◽  
Diabetic Mothers

BACKGROUND: Epicardial fat thickness (EFT) in adults and children has been related to the metabolic syndrome and other cardiovascular risk factors; however, scarce studies have evaluated it in infants of diabetic mothers (IDM) in whom, alterations in the thickness of the interventricular septum have been reported. This study compares the EFT in IDM versus infants of non-diabetic mothers (INDM) and its association with others echocardiographic parameters. METHODS: We performed a cross sectional study in 93 infants (64 IDM and 29 INDM). To evaluate EFT dimensions, an echocardiogram was performed within the first 24h of extrauterine life in both groups. In diabetic mothers, HbA1c was also determined. RESULTS: There was no significant difference in birth weight between the groups although gestational age was lower in IDM. The EFT (3.6 vs. 2.5 mm, p <  0.0001), the interventricular septum thickness (IVST) (6.2 vs. 5.2 mm, p <  0.0001) and the IVST / left ventricle posterior wall (1.3 vs. 1.1, p = 0.001) were higher in the IDM; while the left ventricular expulsion fraction [LVFE] (71.1 vs. 77.8; p <  0.0001) was lower than in the INDM, respectively. We found a positive correlation between EFT with IVST (r = 0.577; p = 0.0001), LVPW (r = 0.262; p = 0.011), IVST/LVPW index (r = 0.353; p = 0.001), and mitral integral early velocity (r = 0.313; p = 0.002), while a negative correlation with LVFE was observed (r = –0.376; p = 0.0001). CONCLUSIONS: The EFT is higher in IDM than in INDM. It was positively related with echocardiographic parameters of left ventricular thickness and negatively with left ventricular ejection function.

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