scholarly journals Oxidative Stress Induced Osteocyte Apoptosis in Steroid‐Induced Femoral Head Necrosis

2021 ◽  
Author(s):  
Zhen‐Qi Fan ◽  
Shu‐Cai Bai ◽  
Qian Xu ◽  
Zhi‐Jun Li ◽  
Wen‐Hao Cui ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Femoral Head ◽  
Femoral Head Necrosis ◽  
Osteocyte Apoptosis

Review on hyperbaric oxygen treatment in femoral head necrosis

2017 ◽  
Vol 44 (6) ◽  
pp. 497-508 ◽  
Author(s):  
Enrico Camporesi ◽  
◽  
Giuliano Vezzani ◽  
Vincenzo Zanon ◽  
Daniele Manelli ◽  
...  
Keyword(s):  
Femoral Head ◽  
Hyperbaric Oxygen ◽  
Femoral Head Necrosis ◽  
Hyperbaric Oxygen Treatment ◽  
Oxygen Treatment

Risk of osteonecrosis in systemic lupus erythematosus: An 11-year Chinese single-center cohort study

Lupus ◽  
2021 ◽  
pp. 096120332110211
Author(s):  
Yin Long ◽  
Shangzhu Zhang ◽  
Jiuliang Zhao ◽  
Hanxiao You ◽  
Li Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systemic Lupus Erythematosus ◽  
Risk Factor ◽  
Femoral Head ◽  
Lupus Erythematosus ◽  
Femoral Head Necrosis ◽  
Joint Involvement ◽  
Multiple Site ◽  
Systemic Lupus ◽  
Cns Involvement

Objective Osteonecrosis (ON), which can lead to physical disability, is a common complication of systemic lupus erythematosus (SLE). The purpose of this study was to determine the prevalence of ON and identify possible risk factors in Chinese SLE patients. Methods SLE patients who fulfilled the 1997 American College of Rheumatology SLE classification criteria were recruited from the Peking Union Medical College Hospital. The chi-square test (χ 2 test) and multivariate regression analyses were used to evaluate risk factors. The Cox proportional-hazards model was used to construct the survival curves and estimate the simultaneous effects of prognostic factors on survival. Results We consecutively enrolled 1,158 patients, of which 88 patients (7.6%) developed ON. Among ON patients, 57.1% of patients had isolated femoral head necrosis and 42.9% had multiple joint involvement. The mean age of ON patients (24.62 ± 8.89 years) was significantly younger than SLE patients without ON (27.23 ± 10.16 years, p = 0.09). The ON group presented with a much longer disease course (10.68 ± 5.97 years, p < 0.001) and increased incidence of arthritis, kidney, and central nervous system (CNS) involvement (65.9% [ p < 0.05], 57.6% [ p < 0.05], and 16.5% [ p < 0.05], respectively, in the ON group). ON patients were more likely to be treated with glucocorticoid (GC) and to receive a high dose of prednisolone at the initial stage of SLE ( p < 0.05). The percentage of patients who received hydroxychloroquine was much higher in the control group ( p < 0.001). Cox regression analysis suggested that CNS involvement and GC therapy were two independent risk factors for ON in SLE patients. The presence of anti-phospholipid antibodies (aPLs) was a risk factor for multiple joint necrosis (odds ratio: 6.28, p = 0.009). Conclusions ON remains a serious and irreversible complication in SLE. In addition to glucocorticoid therapy, we found that CNS system involvement was a risk factor for ON, while the administration of hydroxychloroquine was a protective factor. The clinical characteristics of multiple site ON patients were distinct from isolated femoral head necrosis patients. The presence of aPLs was a risk factor for multiple site osteonecrosis.

Integrated analysis of transcriptome and proteome to explore the genes related to steroid-induced femoral head necrosis

2021 ◽  
Vol 401 (1) ◽  
pp. 112513
Author(s):  
Ning Yang ◽  
Hongzhi Wang ◽  
Weicheng Zhang ◽  
Houyi Sun ◽  
Meng Li ◽  
...  
Keyword(s):  
Femoral Head ◽  
Femoral Head Necrosis ◽  
Integrated Analysis

scholarly journals Hyper-activated platelet lysates prevent glucocorticoid-associated femoral head necrosis by regulating autophagy

2021 ◽  
Vol 139 ◽  
pp. 111711
Author(s):  
Zhipeng Huang ◽  
Qinglong Wang ◽  
Tao Zhang ◽  
Yinsheng Fu ◽  
Wenbo Wang
Keyword(s):  
Femoral Head ◽  
Femoral Head Necrosis

scholarly journals Singleton‐Merten syndrome: A rare cause of femoral head necrosis

2021 ◽  
Author(s):  
Elio Assaf ◽  
Mohamad Bdeir ◽  
Elisabeth Mohs ◽  
Franz‐Joseph Dally ◽  
Sascha Gravius ◽  
...  
Keyword(s):  
Femoral Head ◽  
Femoral Head Necrosis
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