scholarly journals Proposal of New Radiological Classification and Treatment Strategy for Transverse Fractures of the C2 Axis Body

2021 ◽  
Author(s):  
Sung‐Kyu Kim ◽  
Jong‐Hyun Ko ◽  
Jong‐Beom Park ◽  
Hyoung‐Yeon Seo ◽  
Dong‐Gune Chang ◽  
...  
2016 ◽  
Vol 103 (6) ◽  
pp. 686-692 ◽  
Author(s):  
Yasufumi Masaki ◽  
Hiroshi Kawabata ◽  
Kazue Takai ◽  
Masaru Kojima ◽  
Norifumi Tsukamoto ◽  
...  

2021 ◽  
Author(s):  
Zuocheng Yang ◽  
Changxiang Yan ◽  
Zuozhen Yang ◽  
Song Han

Abstract Background The classification and treatment strategy of atypical central neurocytomas (CNs) are still controversial largely, this study aimed to explore the optical treatment strategy and characteristics in transcriptomic profile. Methods This study retrospectively analyzed data from Sixty-one patients with CNs who underwent surgery in single institution. Whole-transcriptome analysis was used to investigate the differences between typical and atypical CNs. Results The five-year OS (P= 0.015) and PFS rates (P= 0.000002) were significantly higher in the complete resection group than in the incomplete resection group. Postoperative radiotherapy did not affect OS (P=0.255) or PFS (P=0.398) in the complete resection group. The five-year PFS rate (P=0.000038) among patients in the complete resection group who did not receive radiotherapy was significantly longer than that among patients in the incomplete resection group who received radiotherapy. The extent of surgical resection and operative approaches were irrelevant to perioperative complications and dsyfunctions at the last follow-up. Compared with caudate control, some of differentially expressed genes may involve cancer. Finally, the overexpression of ten genes (AMOTL1, PIK3R3, TGFBR1, SMO, COL4A6, MGP, SOX4, IGF2, Slit1 and CKS2) in atypical CNs may be associated with malignancy in atypical CNs. Conclusion Complete resection is relatively the best therapeutic modality for atypical CNs, radiotherapy is not necessary for patients after complete resection of the tumor. Although the previous definition of atypical CNs may not have significant prognostic value, the overexpression of ten genes may be involved in malignant behaviors and potential candidate hallmarks for differentiating the atypical CNs. Although the number of cases was relatively small, the findings could be helpful and instructive in the clinical treatment of this disease.


SICOT-J ◽  
2019 ◽  
Vol 5 ◽  
pp. 18 ◽  
Author(s):  
Vaibhav Bagaria ◽  
Gaurav Sharma ◽  
Chaitanya Waghchoure ◽  
Rajendra M Chandak ◽  
Amit Nemade ◽  
...  

Background: Coronal fractures of distal end femur, referred as Hoffa’s fracture are not uncommon, yet easily missed injuries lacking proper classification system and consensus for ideal treatment. While most trauma surgeons adopt different strategies based on the fracture configuration and their own experience, there are no set ways to classify these based on the most appropriate treatment strategy. Methods: Thirty cases of Hoffa fracture from tertiary care centres were studied for the fracture pattern, fragment size, comminution and possible variations to formulate a radiological classification and treatment guidelines. Additionally, a literature search was used to analyze 77 case studies based on Hoffa fracture to find out the common fracture patterns and treatment modalities adopted for varying fracture patterns in these studies. Six independent observers participated in testing the inter-observer reliability of the proposed classification. Results: A new proposed radiological classification for Hoffa fracture consists of four main types. Type 1 is with fracture fragment >2.5 cm, Type 2 with fragment <2.5 cm, Type 3 is comminuted fracture, Type 4 are subdivided as Type 4a – Anterior, Type 4b – Bicondylar, Type 4c – Osteochondral type and Type 4d – With supracondylar extension. Optimum treatment modality depends on the type of Hoffa’s fracture and has been suggested in the study. Interobserver reliability demonstrated that overall agreement was 0.907692 with a fixed marginal Kappa of 0.881067 and free Marginal Kappa at 0.892308. Intra-observer reliability test for the classification system showed a strong Kappa value of +1.0. Conclusion: The new suggested classification helps identify different types of Hoffa’s fracture. This is likely to help decide optimal surgical treatment depending on the nature of the injury. The classification system has high inter and intra-observer reliability that enables its universal applicability.


Spine ◽  
2013 ◽  
Vol 38 (21) ◽  
pp. E1348-E1356 ◽  
Author(s):  
Shenglin Wang ◽  
Chao Wang ◽  
Ming Yan ◽  
Haitao Zhou ◽  
Gengting Dang

HPB ◽  
2016 ◽  
Vol 18 ◽  
pp. e26-e27
Author(s):  
J. Dong ◽  
X. Zheng ◽  
Y. Xu ◽  
H. Xia ◽  
B. Liang ◽  
...  

1996 ◽  
Vol 10 (8) ◽  
pp. 536-540 ◽  
Author(s):  
Yoshikazu Fujimura ◽  
Yukimi Nishi ◽  
Keiji Kobayashi

2005 ◽  
Vol 173 (4S) ◽  
pp. 300-301
Author(s):  
Michaella E. Maloney ◽  
Pei Zhong ◽  
Charles G. Marguet ◽  
Yufeng F. Zhou ◽  
Jeffrey C. Sung ◽  
...  

2004 ◽  
Vol 171 (4S) ◽  
pp. 294-294
Author(s):  
Yufeng Zhou ◽  
Charles G. Marguet ◽  
Michaella E. Maloney ◽  
Franklin H. Cocks ◽  
Glenn M. Preminger ◽  
...  

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