The role of peripheral opioid receptors in orofacial pain

Oral Diseases ◽  
2020 ◽  
Author(s):  
Qing Liu ◽  
Wenguo Fan ◽  
Hongwen He ◽  
Fang Huang
Keyword(s):  
Opioid Receptors ◽  
Orofacial Pain ◽  
Peripheral Opioid Receptors

Morphine initiates migrating myoelectric complexes by acting on peripheral opioid receptors

1985 ◽  
Vol 249 (5) ◽  
pp. G557-G562 ◽  
Author(s):  
G. L. Telford ◽  
M. Hoshmonai ◽  
A. J. Moses ◽  
J. H. Szurszewski
Keyword(s):  
Opioid Receptor ◽  
Opioid Receptors ◽  
Silver Chloride ◽  
Phase Iii ◽  
Opioid Receptor Antagonists ◽  
Peripheral Opioid Receptors ◽  
Silver Silver ◽  
Silver Silver Chloride ◽  
Higher Doses

The role of peripheral and central opioid receptors in morphine-induced migrating myoelectric complexes (MMECs) was studied in conscious dogs implanted with silver-silver chloride electrodes. In normal fasted dogs morphine (100-200 micrograms/kg iv) initiated phase III of the MMEC in the duodenum. Once initiated the MMEC propagated distally. This effect of morphine was blocked by the opioid receptor antagonists naloxone (2 mg/kg iv) and N,N-diallylnormorphinium bromide (4 mg/kg iv). Higher doses of morphine (300-600 micrograms/kg iv) initiated phase III activity in fed dogs as early as 20 min after feeding, while lower doses (150 micrograms/kg iv) initiated phase III activity routinely when administered 100 min after feeding. In dogs with bilateral vagotomies and bilateral thoracolumbar sympathetic chain ganglionectomies, morphine (150 micrograms/kg iv) initiated phase III activity in the duodenum, which then migrated distally. This study demonstrates that morphine initiates phase III of the MMEC by acting through peripheral opioid receptors.

scholarly journals The Role of Peripheral Opioid Receptors in Triggering Heroin-induced Brain Hypoxia

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
David Perekopskiy ◽  
Anum Afzal ◽  
Shelley N. Jackson ◽  
Ludovic Muller ◽  
Amina S. Woods ◽  
...  
Keyword(s):  
Opioid Receptors ◽  
Brain Hypoxia ◽  
Peripheral Opioid Receptors

Role of central versus peripheral opioid receptors in analgesia induced by repeated administration of opioid antagonists

1991 ◽  
Vol 104 (2) ◽  
pp. 164-166 ◽  
Author(s):  
M. J. Katharine Walker ◽  
A. D. Lê ◽  
Constantine X. Poulos ◽  
Howard Cappell
Keyword(s):  
Opioid Receptors ◽  
Repeated Administration ◽  
Opioid Antagonists ◽  
Peripheral Opioid Receptors

scholarly journals (367) Interrogating the role of peripheral opioid receptors using an optogenetic approach

2016 ◽  
Vol 17 (4) ◽  
pp. S67
Author(s):  
H. Beaudry ◽  
I. Daou ◽  
A. Ribeiro-Da-Silva ◽  
P. Séguéla
Keyword(s):  
Opioid Receptors ◽  
Peripheral Opioid Receptors

scholarly journals Peripherally Acting Opioids in Orofacial Pain

2021 ◽  
Vol 15 ◽  
Author(s):  
Qing Liu ◽  
Hongwen He ◽  
Lijia Mai ◽  
Shengyan Yang ◽  
Wenguo Fan ◽  
...  
Keyword(s):  
Opioid Receptors ◽  
Orofacial Pain ◽  
Immune Cell ◽  
Region Growing ◽  
Endogenous Opioids ◽  
Cellular Mechanisms ◽  
Endogenous Opioid ◽  
Peripheral Tissues ◽  
Analgesic Effects ◽  
Peripheral Opioid Receptors

The activation of opioid receptors by exogenous or endogenous opioids can produce significant analgesic effects in peripheral tissues. Numerous researchers have demonstrated the expression of peripheral opioid receptors (PORs) and endogenous opioid peptides (EOPs) in the orofacial region. Growing evidence has shown the involvement of PORs and immune cell-derived EOPs in the modulation of orofacial pain. In this review, we discuss the role of PORs and EOPs in orofacial pain and the possible cellular mechanisms involved. Furthermore, the potential development of therapeutic strategies for orofacial pain is also summarized.

Role of the thalamic submedius nucleus histamine H1 and H2 and opioid receptors in modulation of formalin-induced orofacial pain in rats

2015 ◽  
Vol 388 (10) ◽  
pp. 1089-1096 ◽  
Author(s):  
Amir Erfanparast ◽  
Esmaeal Tamaddonfard ◽  
Mina Taati ◽  
Milad Dabaghi
Keyword(s):  
Opioid Receptors ◽  
Orofacial Pain
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