Role of central versus peripheral opioid receptors in analgesia induced by repeated administration of opioid antagonists

1991 ◽  
Vol 104 (2) ◽  
pp. 164-166 ◽  
Author(s):  
M. J. Katharine Walker ◽  
A. D. Lê ◽  
Constantine X. Poulos ◽  
Howard Cappell
Keyword(s):  
Opioid Receptors ◽  
Repeated Administration ◽  
Opioid Antagonists ◽  
Peripheral Opioid Receptors

The role of peripheral opioid receptors in orofacial pain

Oral Diseases ◽  
2020 ◽  
Author(s):  
Qing Liu ◽  
Wenguo Fan ◽  
Hongwen He ◽  
Fang Huang
Keyword(s):  
Opioid Receptors ◽  
Orofacial Pain ◽  
Peripheral Opioid Receptors

Morphine initiates migrating myoelectric complexes by acting on peripheral opioid receptors

1985 ◽  
Vol 249 (5) ◽  
pp. G557-G562 ◽  
Author(s):  
G. L. Telford ◽  
M. Hoshmonai ◽  
A. J. Moses ◽  
J. H. Szurszewski
Keyword(s):  
Opioid Receptor ◽  
Opioid Receptors ◽  
Silver Chloride ◽  
Phase Iii ◽  
Opioid Receptor Antagonists ◽  
Peripheral Opioid Receptors ◽  
Silver Silver ◽  
Silver Silver Chloride ◽  
Higher Doses

The role of peripheral and central opioid receptors in morphine-induced migrating myoelectric complexes (MMECs) was studied in conscious dogs implanted with silver-silver chloride electrodes. In normal fasted dogs morphine (100-200 micrograms/kg iv) initiated phase III of the MMEC in the duodenum. Once initiated the MMEC propagated distally. This effect of morphine was blocked by the opioid receptor antagonists naloxone (2 mg/kg iv) and N,N-diallylnormorphinium bromide (4 mg/kg iv). Higher doses of morphine (300-600 micrograms/kg iv) initiated phase III activity in fed dogs as early as 20 min after feeding, while lower doses (150 micrograms/kg iv) initiated phase III activity routinely when administered 100 min after feeding. In dogs with bilateral vagotomies and bilateral thoracolumbar sympathetic chain ganglionectomies, morphine (150 micrograms/kg iv) initiated phase III activity in the duodenum, which then migrated distally. This study demonstrates that morphine initiates phase III of the MMEC by acting through peripheral opioid receptors.

scholarly journals The Role of Peripheral Opioid Receptors in Triggering Heroin-induced Brain Hypoxia

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
David Perekopskiy ◽  
Anum Afzal ◽  
Shelley N. Jackson ◽  
Ludovic Muller ◽  
Amina S. Woods ◽  
...  
Keyword(s):  
Opioid Receptors ◽  
Brain Hypoxia ◽  
Peripheral Opioid Receptors

scholarly journals (367) Interrogating the role of peripheral opioid receptors using an optogenetic approach

2016 ◽  
Vol 17 (4) ◽  
pp. S67
Author(s):  
H. Beaudry ◽  
I. Daou ◽  
A. Ribeiro-Da-Silva ◽  
P. Séguéla
Keyword(s):  
Opioid Receptors ◽  
Peripheral Opioid Receptors

scholarly journals Functional role of peripheral opioid receptors in the regulation of cardiac spinal afferent nerve activity during myocardial ischemia

2013 ◽  
Vol 305 (1) ◽  
pp. H76-H85 ◽  
Author(s):  
Liang-Wu Fu ◽  
John C. Longhurst
Keyword(s):  
Myocardial Ischemia ◽  
Opioid Receptors ◽  
Opioid Peptides ◽  
Nerve Fibers ◽  
Afferent Nerve ◽  
Nerve Activity ◽  
Afferent Nerves ◽  
Peripheral Opioid Receptors ◽  
Cardiac Afferents

Thinly myelinated Aδ-fiber and unmyelinated C-fiber cardiac sympathetic (spinal) sensory nerve fibers are activated during myocardial ischemia to transmit the sensation of angina pectoris. Although recent observations showed that myocardial ischemia increases the concentrations of opioid peptides and that the stimulation of peripheral opioid receptors inhibits chemically induced visceral and somatic nociception, the role of opioids in cardiac spinal afferent signaling during myocardial ischemia has not been studied. The present study tested the hypothesis that peripheral opioid receptors modulate cardiac spinal afferent nerve activity during myocardial ischemia by suppressing the responses of cardiac afferent nerve to ischemic mediators like bradykinin and extracellular ATP. The nerve activity of single unit cardiac afferents was recorded from the left sympathetic chain (T2–T5) in anesthetized cats. Forty-three ischemically sensitive afferent nerves (conduction velocity: 0.32–3.90 m/s) with receptive fields in the left and right ventricles were identified. The responses of these afferent nerves to repeat ischemia or ischemic mediators were further studied in the following protocols. First, epicardial administration of naloxone (8 μmol), a nonselective opioid receptor antagonist, enhanced the responses of eight cardiac afferent nerves to recurrent myocardial ischemia by 62%, whereas epicardial application of vehicle (PBS) did not alter the responses of seven other cardiac afferent nerves to ischemia. Second, naloxone applied to the epicardial surface facilitated the responses of seven cardiac afferent nerves to epicardial ATP by 76%. Third, administration of naloxone enhanced the responses of seven other afferent nerves to bradykinin by 85%. In contrast, in the absence of naloxone, cardiac afferent nerves consistently responded to repeated application of ATP ( n = 7) or bradykinin ( n = 7). These data suggest that peripheral opioid peptides suppress the responses of cardiac sympathetic afferent nerves to myocardial ischemia and ischemic mediators like ATP and bradykinin.

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