Expression of ameloblastin in the human tooth germ and ameloblastoma

Oral Diseases ◽  
2018 ◽  
Vol 24 (8) ◽  
pp. 1538-1544
Author(s):  
Suganya Panneer Selvam ◽  
Irulandy Ponniah
Keyword(s):  
Tooth Germ ◽  
Human Tooth ◽  
Human Tooth Germ

In vitro differentiation of human tooth germ stem cells into endothelial- and epithelial-like cells

2014 ◽  
Vol 39 (1) ◽  
pp. 94-103 ◽  
Author(s):  
Ayşegül Doğan ◽  
Selami Demirci ◽  
Fikrettin Şahin
Keyword(s):  
Stem Cells ◽  
Tooth Germ ◽  
Human Tooth ◽  
In Vitro Differentiation ◽  
Human Tooth Germ

Influence of STRO-1 selection on osteogenic potential of human tooth germ derived mesenchymal stem cells

2017 ◽  
Vol 82 ◽  
pp. 293-301 ◽  
Author(s):  
Pinar Ercal ◽  
Gorke G. Pekozer ◽  
Osman Z. Gumru ◽  
Gamze T. Kose ◽  
Mustafa Ramazanoglu
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tooth Germ ◽  
Human Tooth ◽  
Osteogenic Potential ◽  
Human Tooth Germ

Cartilage tissue engineering on macroporous scaffolds using human tooth germ stem cells

2015 ◽  
Vol 11 (3) ◽  
pp. 765-777 ◽  
Author(s):  
A. C. Calikoglu Koyuncu ◽  
G. Gurel Pekozer ◽  
M. Ramazanoglu ◽  
G. Torun Kose ◽  
V. Hasirci
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Cartilage Tissue Engineering ◽  
Tooth Germ ◽  
Cartilage Tissue ◽  
Human Tooth ◽  
Human Tooth Germ

A Genome-Wide Analysis of mRNA Expression in Human Tooth Germ Stem Cells Treated with Pluronic P85

2016 ◽  
Vol 6 (4) ◽  
pp. 392-402
Author(s):  
Atousa Ataei ◽  
Valeria V. Solovyeva ◽  
Mansour Poorebrahim ◽  
Nataliya L. Blatt ◽  
Ilnur I. Salafutdinov ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mrna Expression ◽  
Tooth Germ ◽  
Human Tooth ◽  
Genome Wide Analysis ◽  
Genome Wide ◽  
A Genome ◽  
Human Tooth Germ ◽  
Pluronic P85

Effect of F68, F127, and P85 Pluronic Block Copolymers on Odontogenic Differentiation of Human Tooth Germ Stem Cells

2013 ◽  
Vol 39 (10) ◽  
pp. 1265-1271 ◽  
Author(s):  
Pakize Neslihan Taşlı ◽  
Mehmet Emir Yalvaç ◽  
Nesimi Sofiev ◽  
Fikrettin Şahin
Keyword(s):  
Stem Cells ◽  
Block Copolymers ◽  
Tooth Germ ◽  
Human Tooth ◽  
Odontogenic Differentiation ◽  
Pluronic Block Copolymers ◽  
Human Tooth Germ

Bmp 2 and Bmp 7 Induce Odonto- And Osteogenesis of Human Tooth Germ Stem Cells

2014 ◽  
Vol 172 (6) ◽  
pp. 3016-3025 ◽  
Author(s):  
P. Neslihan Taşlı ◽  
Safa Aydın ◽  
Mehmet Emir Yalvaç ◽  
Fikrettin Şahin
Keyword(s):  
Stem Cells ◽  
Tooth Germ ◽  
Human Tooth ◽  
Human Tooth Germ

scholarly journals A single-cell interactome of human tooth germ from growing third molar elucidates signaling networks regulating dental development

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yueqi Shi ◽  
Yejia Yu ◽  
Yuqiong Zhou ◽  
Jun Zhao ◽  
Wenjie Zhang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Single Cell ◽  
Transforming Growth Factor ◽  
Developmental Process ◽  
Interleukin 1 ◽  
Third Molar ◽  
Tooth Germ ◽  
Human Tooth ◽  
Signaling Networks ◽  
Human Tooth Germ

Abstract Background Development of dental tissue is regulated by extensive cell crosstalk based on various signaling molecules, such as bone morphogenetic protein (BMP) and fibroblast growth factor (FGF) pathways. However, an intact network of the intercellular regulation is still lacking. Result To gain an unbiased and comprehensive view of this dental cell interactome, we applied single-cell RNA-seq on immature human tooth germ of the growing third molar, discovered refined cell subtypes, and applied multiple network analysis to identify the central signaling pathways. We found that immune cells made up over 80% of all tooth germ cells, which exhibited profound regulation on dental cells via Transforming growth factor-β, Tumor necrosis factor (TNF) and Interleukin-1. During osteoblast differentiation, expression of genes related to extracellular matrix and mineralization was continuously elevated by signals from BMP and FGF family. As for the self-renewal of apical papilla stem cell, BMP-FGFR1-MSX1 pathway directly regulated the G0-to-S cell cycle transition. We also confirmed that Colony Stimulating Factor 1 secreted from pericyte and TNF Superfamily Member 11 secreted from osteoblast regulated a large proportion of genes related to osteoclast transformation from macrophage and monocyte. Conclusions We constructed the intercellular signaling networks that regulated the essential developmental process of human tooth, which served as a foundation for future dental regeneration engineering and the understanding of oral pathology.

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