Clinical significance of aberrant vimentin expression in oral premalignant lesions and carcinomas

Oral Diseases ◽  
2013 ◽  
Vol 20 (5) ◽  
pp. 453-465 ◽  
Author(s):  
SS Sawant ◽  
MM Vaidya ◽  
DA Chaukar ◽  
H Alam ◽  
C Dmello ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Premalignant Lesions ◽  
Vimentin Expression

scholarly journals TWIST1 expression and clinical significance in type I endometrial cancer and premalignant lesions

Medicine ◽  
2020 ◽  
Vol 99 (48) ◽  
pp. e23397
Author(s):  
Junhua Shen ◽  
Qin Chen ◽  
Na Li ◽  
Xiaoxia Bai ◽  
Fenfen Wang ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Clinical Significance ◽  
Premalignant Lesions ◽  
Type I ◽  
Twist1 Expression

scholarly journals Vimentin expression in pancreatic cancer and its clinical significance

2007 ◽  
Vol 15 (36) ◽  
pp. 3822
Author(s):  
Tao Yin ◽  
Chun-You Wang ◽  
Jiong-Xin Xiong ◽  
Jing Tao ◽  
Gang Zhao
Keyword(s):  
Pancreatic Cancer ◽  
Clinical Significance ◽  
Vimentin Expression

scholarly journals Endometrial Metaplastic/Reactive Changes Coexistent with Endometrial Hyperplasia and Carcinoma: A Morphological and Immunohistochemical Study

Diagnostics ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 63
Author(s):  
Antonio Travaglino ◽  
Frediano Inzani ◽  
Angela Santoro ◽  
Damiano Arciuolo ◽  
Alessia Piermattei ◽  
...  
Keyword(s):  
Endometrial Hyperplasia ◽  
Precancerous Lesions ◽  
Premalignant Lesions ◽  
Serous Carcinoma ◽  
Vimentin Expression ◽  
Ki67 Expression ◽  
Pten Loss ◽  
Nuclear Atypia ◽  
Reactive Changes ◽  
P16 Expression

The aim of this study was to assess the relationship between endometrial metaplastic/reactive changes (EMRCs) and endometrial neoplastic lesions. Twenty cases of “simple” (without architecture complexity) EMRCs coexistent with endometrial malignant/premalignant lesions, twenty cases of neoplasia-unassociated EMRCs, and eight cases of complex metaplastic lesions were assessed by immunohistochemistry. EMRCs coexisted with endometrioid carcinoma (n = 12), atypical endometrial hyperplasia (n = 3), serous carcinoma (n = 2), and clear cell carcinoma (n = 3). Neoplasia-associated EMRCs showed a mean Ki67 labeling index of 12.6% (range 0–30%); with nuclear atypia in 16/20 (80%) cases; diffuse p16 expression in 15/20 (75%) cases; and heterogeneous ER, PR, and vimentin expression. Compared to the associated neoplasia, EMRCs showed a lower Ki67 expression (p < 0.001) and higher p16 expression (p < 0.001). No EMRC case showed mitotic activity, PTEN loss, MMR deficiency, nuclear β-catenin, p53-mutant pattern, Napsin A, or AMACR expression. No significant differences were found between neoplasia-associated and neoplasia-unassociated EMRCs. Complex metaplastic lesions showed a lower Ki67 expression than EMRCs (p = 0.044) and PTEN loss in 5/8 cases, even in the absence of nuclear atypia. In conclusion, neoplasia-associated simple EMRCs may show evident atypia and a worrisome immunophenotype, but no data support their involvement in endometrial carcinogenesis. Architectural complexity appears as a crucial factor to identify precancerous lesions.

Expression of the HPV18E2 Gene in Cervical Cancer and Premalignant Lesions and its Clinical Significance

2014 ◽  
Vol 70 (2) ◽  
pp. 841-844
Author(s):  
Ling Mou ◽  
Bin Wu ◽  
Ya Hu ◽  
Ying Lan ◽  
Feng-Lin Lv
Keyword(s):  
Cervical Cancer ◽  
Clinical Significance ◽  
Premalignant Lesions

scholarly journals Clinical Significance of Vimentin Expression and Her-2 Status in Patients with Gastric Carcinoma

2013 ◽  
Vol 6 (3) ◽  
pp. 184-190 ◽  
Author(s):  
Wenwen Zhao ◽  
Lu Yue ◽  
Fang Zhou ◽  
Congcong Xu ◽  
Wanhua Liang ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Clinical Significance ◽  
Vimentin Expression ◽  
Her 2

Clinical significance of cathepsin E in pancreatic juice in the diagnosis of pancreatic ductal adenocarcinoma

2000 ◽  
Vol 15 (11) ◽  
pp. 1333-1338 ◽  
Author(s):  
Koji Uno ◽  
Takeshi Azuma ◽  
Masatsugu Nakajima ◽  
Kenjiro Yasuda ◽  
Takanobu Hayakumo ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Clinical Significance ◽  
Pancreatic Juice ◽  
Ductal Adenocarcinoma ◽  
Cathepsin E
Sign in / Sign up

Export Citation Format

Share Document