scholarly journals Clinical Significance of Vimentin Expression and Her-2 Status in Patients with Gastric Carcinoma

2013 ◽  
Vol 6 (3) ◽  
pp. 184-190 ◽  
Author(s):  
Wenwen Zhao ◽  
Lu Yue ◽  
Fang Zhou ◽  
Congcong Xu ◽  
Wanhua Liang ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Clinical Significance ◽  
Vimentin Expression ◽  
Her 2

scholarly journals Clinical Significance and Regulation of Vascular Involvement in Gastric Carcinoma.

1998 ◽  
Vol 31 (10) ◽  
pp. 2157-2161
Author(s):  
Shunichi Tsujitani ◽  
Hiroaki Saito ◽  
Shinichi Oka ◽  
Akira Kondo ◽  
Ichiro Konishi ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Clinical Significance ◽  
Vascular Involvement

Clinical significance of MHC class II-associated invariant chain expression in human gastric carcinoma

2005 ◽  
Author(s):  
Yasuhiro Tamori ◽  
Xiaodong Tan ◽  
Kazuhiro Nakagawa ◽  
Eiji Takai ◽  
Junji Akagi ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Clinical Significance ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Invariant Chain ◽  
Human Gastric Carcinoma

scholarly journals The expression and clinical significance of PDCD4 and Her-2 in human gastric cancer

2019 ◽  
Vol 17 ◽  
pp. 205873921982823
Author(s):  
Yuelou Yang ◽  
Xiangjun Jiang ◽  
Dong Li ◽  
Feiyan Wang ◽  
Qun Yang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Protein Expression ◽  
Western Blot ◽  
Clinical Significance ◽  
Normal Mucosa ◽  
Normal Tissues ◽  
Positive Rate ◽  
Her 2 ◽  
Cancer Tissues ◽  
Pdcd4 Protein

To investigate the correlation and clinical significance between programmed cell death factor 4 (PDCD4) and epidermal growth factor receptor 2 (Her-2) expressions and clinicopathological parameters in patients with gastric cancer, a total of 65 cases of gastric cancer and the corresponding normal mucosa with PDCD4 and Her-2 protein expressions were detected by SP immunohistochemical staining, and 50 cases of gastric cancer and the corresponding normal mucosa with PDCD4 and Her-2 protein expression quantities were detected by Western blot, in order to analyze the relationship between the positive expressions of PDCD4 and Her-2 protein and the clinicopathological features of patients with gastric cancer. The results showed that the positive rate of PDCD4 protein expression in gastric cancer tissues was 7.7%, which was significantly lower than that in the corresponding normal tissues, that is, 77.5% ( P < 0.05); the positive rate of Her-2 expression was 41.5%, which was significantly higher than that of the corresponding normal tissues, which is 2.5% ( P < 0.05). The Western blot test showed that the expression of PDCD4 protein in gastric cancer was 0.3105 ± 0.0073, which was significantly lower than that in the corresponding normal tissues, that is, 0.9428 ± 0.0127 ( P < 0.05); the expression level of Her-2 protein in gastric cancer tissues was 0.9428 ± 0.0127, which was significantly higher than that of the corresponding normal mucosa, which is 0.2054 ± 0.0264 ( P < 0.05). The positive expressions of PDCD4 (5/65) and Her-2 (27/65) were significantly correlated with the differentiation degrees and TNM stages of gastric cancer ( P < 0.05). However, no significant correlation can be observed from Table 2 ( P > 0.05), regarding sex, age, tumor size, and lymph node metastasis. Our research claimed that PDCD4 and Her-2 may play an important role in the invasion and metastasis of gastric cancer, which has a negative correlation with biological behaviors of gastric cancer. The low expression of PDCD4 and the high expression of Her-2 in gastric cancer may promote the occurrence and progression of cancer. The PDCD4 and Her-2 test can be used as an index to evaluate the malignant biological behaviors of gastric cancer and prognosis, and provide a theoretical basis for targeted therapy.

scholarly journals IDDF2019-ABS-0153 Clinical significance of seprase and connexin-43 expression in gastric carcinoma

2019 ◽  
Author(s):  
Fangrui Yin ◽  
Yunqi Hua ◽  
Xianfeng Liu ◽  
Yongyan Yang ◽  
Chenlin Wang ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Clinical Significance ◽  
Connexin 43
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