scholarly journals Impact of pharmacologic inhibition of tooth movement on periodontal and tooth root tissues during orthodontic force application

2019 ◽  
Vol 23 (1) ◽  
pp. 35-43
Author(s):  
Sarah J. Baxter ◽  
Inna Sydorak ◽  
Peter X. Ma ◽  
Nan E. Hatch
2016 ◽  
Vol 19 (2) ◽  
pp. 83-92 ◽  
Author(s):  
K. Arita ◽  
H. Hotokezaka ◽  
M. Hashimoto ◽  
T. Nakano-Tajima ◽  
T. Kurohama ◽  
...  

2018 ◽  
Vol 88 (6) ◽  
pp. 733-739 ◽  
Author(s):  
Nurhat Ozkalayci ◽  
Ersan Ilsay Karadeniz ◽  
Selma Elekdag-Turk ◽  
Tamer Turk ◽  
Lam L. Cheng ◽  
...  

ABSTRACT Objectives: To compare the extent of root resorption and the amount of tooth movement between continuous orthodontic force and intermittent orthodontic force that was activated in a similar way to a 4-week orthodontic adjustment period. Materials and Methods: Twenty-five patients who required the extraction of upper first premolars were recruited in this study. A buccally directed continuous force of 150 g was applied to the upper first premolar on one side for 15 weeks. A buccally directed intermittent force (28 days on, 7 days off) of the same magnitude was applied to the contralateral first premolar. The teeth were extracted at the end of the experimental period and processed for volumetric evaluations of resorption craters. The degree of tooth movement and rotation were measured on the study models. Results: Continuous force application displayed significantly higher root resorption volume than the intermittent force application (P < .05), particularly on the buccal and lingual surfaces (P < .05) and the middle third of the root (P < .01). There was more tipping and rotational movement in the continuous force group. Conclusions: In a 4-week orthodontic adjustment period, intermittent force significantly reduced the amount of root resorption compared with continuous force. Although there was less degree of tooth movement with intermittent force, unwanted rotational movement was avoided. This is crucial in patients who are predisposed to orthodontically induced inflammatory root resorption, and the use of this intermittent regimen should be considered.


2018 ◽  
Vol 6 (02/03) ◽  
pp. 053-056
Author(s):  
Ritunja Singh ◽  
Shilpa Chourasia ◽  
Palak Sharma ◽  
Soumya Gupta ◽  
Gangesh Singh ◽  
...  

AbstractPeriodontally accelerated osteogenic orthodontics (PAOO), also known as Wilckodontics, is a clinical procedure that combines corticotomy (a surgical technique in which the bone is cut, perforated, or mechanically altered), particulate bone grafting, and orthodontic force application. By this procedure, the teeth can be made to move through the bone rapidly by means of harnessing and stimulating the innate potential of the bone and utilizing tissue engineering principles. Once the tooth movement gets completed, bone rebuilds around the tooth, thereby reducing the time of orthodontic treatment from years to months. This article aims to present a comprehensive review about PAOO or Wilckodontics.


2010 ◽  
Vol 75 (4) ◽  
pp. 405-407 ◽  
Author(s):  
Xiaomei Xu ◽  
Qing Zhao ◽  
Siwei Yang ◽  
Guangxin Fu ◽  
Yangxi Chen

2019 ◽  
Vol 24 (2) ◽  
pp. 40.e1-40.e22 ◽  
Author(s):  
Priyanka Kapoor ◽  
Nitika Monga ◽  
Om Prakash Kharbanda ◽  
Sunil Kapila ◽  
Ragini Miglani ◽  
...  

Abstract Objective: Orthodontic force application releases multiple enzymes in gingival crevicular fluid (GCF) for activation, resorption, reversal, deposition of osseous elements and extracellular matrix degradation. The current systematic review critically evaluated all existing evidence on enzymes in orthodontic tooth movement. Methods: Literature was searched with predetermined search strategy on electronic databases (PubMed, Scopus, Embase), along with hand search. Results: Initial search identified 652 studies, shortlisted to 52 studies based on PRISMA. Quality assessment further led to final inclusion of 48 studies (13 moderately and 35 highly sensitive studies). Primary outcomes are significant upregulation in GCF levels of enzymes-aspartate aminotransferase (AST), alkaline phosphatase (ALP), matrix metalloproteinases (MMPs), lactate dehydrogenase (LDH), β-glucuronidase (βG), tartrate resistant acid phosphatase (TRAP), acid phosphatase (ACP) and down regulation in cathepsin B (Cb). Site specificity is shown by ALP, TRAP, AST, LDH, MMP9 with levels at compression site increasing earlier and in higher quantities compared with tension site. ALP levels are higher at tension site only in retention. A positive correlation of LDH, ALP and AST is also observed with increasing orthodontic force magnitude. Conclusions: A strong evidence of variation in enzymes (ALP, AST, ACP TRAP, LDH, MMPs, Cb) in GCF is found in association with different magnitude, stages and sites of orthodontic force application.


Sensors ◽  
2020 ◽  
Vol 20 (2) ◽  
pp. 497 ◽  
Author(s):  
Letizia Perillo ◽  
Fabrizia d’Apuzzo ◽  
Maddalena Illario ◽  
Luigi Laino ◽  
Gaetano Di Spigna ◽  
...  

The aim of the study was to examine the biochemical and structural changes occurring in the periodontal ligament (PDL) during orthodontic-force application using micro-Raman spectroscopy ( μ -RS). Adolescent and young patients who needed orthodontic treatment with first premolar extractions were recruited. Before extractions, orthodontic forces were applied using a closed-coil spring that was positioned between the molar and premolar. Patients were randomly divided into three groups, whose extractions were performed after 2, 7, and 14 days of force application. From the extracted premolars, PDL samples were obtained, and a fixation procedure with paraformaldehyde was adopted. Raman spectra were acquired for each PDL sample in the range of 1000–3200 cm − 1 and the more relevant vibrational modes of proteins (Amide I and Amide III bands) and CH 2 and CH 3 modes were shown. Analysis indicated that the protein structure in the PDL samples after different time points of orthodontic-force application was modified. In addition, changes were observed in the CH 2 and CH 3 high wavenumber region due to local hypoxia and mechanical force transduction. The reported results indicated that μ -RS provides a valuable tool for investigating molecular interchain interactions and conformational modifications in periodontal fibers after orthodontic tooth movement, providing quantitative insight of time occurring for PDL molecular readjustment.


2008 ◽  
Vol 78 (2) ◽  
pp. 299-303 ◽  
Author(s):  
Koji Fujiyama ◽  
Toru Deguchi ◽  
Takashi Murakami ◽  
Akihito Fujii ◽  
Kazuhiko Kushima ◽  
...  

Abstract Objective: To test the hypothesis that there is no difference in the pain associated with orthodontic force application after the application of local CO2 laser irradiation to the teeth involved. Materials and Methods: Separation modules were placed at the distal contacts of the maxillary first molars in 90 patients in this single-blinded study. In 60 of these patients (42 females and 18 males; mean age = 19.22 years) this was immediately followed by laser therapy. The other 30 patients (18 females and 12 males; mean age = 18.8 years) did not receive active laser irradiation. Patients were then instructed to rate their levels of pain on a visual analog scale over time, and the amount of tooth movement was analyzed. Results: Significant pain reductions were observed with laser treatment from immediately after insertion of separators through day 4, but no differences from the nonirradiated control side were noted thereafter. No significant difference was noted in the amount of tooth movement between the irradiated and nonirradiated group. Conclusions: The hypothesis was rejected. The results suggest that local CO2 laser irradiation will reduce pain associated with orthodontic force application without interfering with the tooth movement.


el–Hayah ◽  
2015 ◽  
Vol 5 (2) ◽  
pp. 97
Author(s):  
Nuzulul Hikmah

<p><em>Orthodontic tooth movement is obtained through </em><em>alveolar bone remodeling</em><em>. Alveolar bone remodeling includes reso</em><em>rption</em><em> process </em><em>that </em><em>played by osteoclasts and </em><em>bone formed</em><em> process </em><em>that </em><em>played by osteoblasts. Diabetes affects </em><em>on </em><em>orthodontic tooth movement. </em><em>The magnitude of</em><em> orthodontic force </em><em>that</em><em> applied </em><em>in</em><em> the early stages of diabetic conditions,</em><em> would be</em><em> a consideration of the </em><em>alveolar bone</em><em> remodeling process. The purpose of this study was to determine osteo</em><em>b</em><em>last and osteo</em><em>c</em><em>last</em><em> profile </em><em>in </em><em>early stage of rat diabetic </em><em>models </em><em>with different</em><em> orthodontic force application. 2</em><em>4</em><em> Wistar rats were divided into </em><em>three</em><em> groups of control</em><em>s andthree groups of early stage of</em><em> diabetic treatment with different orthodontic force application (10, 20, and 30 </em><em>gramforce</em><em>/</em><em>g</em><em>r</em><em>f). The results showed an increase</em><em>d </em><em>of osteoclast</em><em> numbers in early stage of</em><em> diabet</em><em>es and will be increased along with the increased of orthodontic force. </em><em>The results </em><em>also </em><em>showed</em><em> a decreased of </em><em>osteoblast</em><em> number in early stage of</em><em> diabet</em><em>es, but it would be increased along with the increased of orthodontic force</em><em>. </em></p>


2011 ◽  
Vol 81 (4) ◽  
pp. 570-577 ◽  
Author(s):  
Irin Sirisoontorn ◽  
Hitoshi Hotokezaka ◽  
Megumi Hashimoto ◽  
Carmen Gonzales ◽  
Suwannee Luppanapornlarp ◽  
...  

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